Abstract
Aims
Duodenal ulcer perforations are frequently encountered but there is limited literature regarding risk factors for leak after omentopexy.
Methodology
The record of 100 patients of duodenal ulcer perforation undergoing omentopexy by open approach was prospectively maintained to identify any significant factors contributing towards leak.
Results
Out of 100 patients undergoing omentopexy, 9 (9%) developed leak; when leak occurred, the mortality was very high (44.4%). Patients who developed leak (09) were compared against those who did not (91), and it was seen that seen that duration of symptoms before surgery (> 3 days), amount of intra-abdominal contamination (> 2 L), low body mass index (BMI < 19.35 kg/m2), serum creatinine (> 1.5 mg/dl), and deranged International Normalized Ratio (INR) were found to be significant on univariate analysis; however, multivariate analysis revealed only low BMI and high creatinine to be contributory towards leak.
Conclusion
Leak after omentopexy carries a high morbidity and mortality. Identification of risk factors may help in optimizing patients at risk and reduce the incidence of leak and its sequelae.
Trial registration number
CTRI/2020/03/023798.
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References
Chung KT, Shelat VG. Perforated peptic ulcer - an update. World J Gastrointest Surg. 2017;9:1–12. https://doi.org/10.4240/wjgs.v9.i1.1.
Kumar K, Pai D, Srinivasan K, et al. Factors contributing to releak after surgical closure of perforated duodenal ulcer by Graham’s Patch. Trop Gastroenterol. 2002;23:190–2.
Sharma SS, Mamtani MR, Sharma MS, et al. A prospective cohort study of postoperative complications in the management of perforated peptic ulcer. BMC Surg. 2006;6:8. https://doi.org/10.1186/1471-2482-6-8.
Chan KS, Wang YL, Chan XW, et al. Outcomes of omental patch repair in large or giant perforated peptic ulcer are comparable to gastrectomy. Eur J Trauma Emerg Surg. 2021;47:1745–52. https://doi.org/10.1007/s00068-019-01237-8.
Maghsoudi H, Ghaffari A. Generalized peritonitis requiring re-operation after leakage of omental patch repair of perforated peptic ulcer. Saudi J Gastroenterol. 2011;17:124–8. https://doi.org/10.4103/1319-3767.77243.
Agarwal N, Gupta A, Jain B, et al. Omental patch repair for duodenal ulcer perforation- analysis of factors affecting outcome: a prospective study. J Gastroenterol Pancreatol Liver Disord. 2018;6:1–6. https://doi.org/10.15226/2374-815X/6/2/001125.
Lund S, Chauhan KK, Zietlow J, et al. Risk factors for gastrointestinal leak after perforated peptic ulcer disease operative repair. Am Surg. 2021;87:1879–85. https://doi.org/10.1177/00031348211056263.
Gupta S, Kaushik R, Sharma R, et al. The management of large perforations of duodenal ulcers. BMC Surg. 2005;5:15. https://doi.org/10.1186/1471-2482-5-15.
Cellan-Jones C. A rapid method of treatment in perforated duodenal ulcer. Br Med J. 1929;1:1076–7.
Tarasconi A, Coccolini F, Biffl WL, et al. Perforated and bleeding peptic ulcer: WSES guidelines. World J Emerg Surg. 2020;15:3. https://doi.org/10.1186/s13017-019-0283-9.
Sivaram P, Sreekumar A. Preoperative factors influencing mortality and morbidity in peptic ulcer perforation. Eur J Trauma Emerg Surg. 2018;44:251–7. https://doi.org/10.1007/s00068-017-0777-7.
Nomani AZ, Malik AK, Qureshi MS. A new prognostic scoring system for perforation peritonitis secondary to duodenal ulcers. J Pak Med Assoc. 2014;64:50–6.
Etonyeaku AC, Agbakwuru EA, Akinkuolie AA, et al. A review of the management of perforated duodenal ulcers at a tertiary hospital in south western Nigeria. Afr Health Sci. 2013;13:907–13. https://doi.org/10.4314/ahs.v13i4.7.
Seyoum N, Ethicha D, Assefa Z, et al. Risk factors that affect morbidity and mortality in patients with perforated peptic ulcer diseases in a teaching hospital. Ethiop J Health Sci. 2020;30:549–58. https://doi.org/10.4314/ejhs.v30i4.10.
Lohsiriwat V, Prapasrivorakul S, Lohsiriwat D. Perforated peptic ulcer: clinical presentation, surgical outcomes, and the accuracy of the boey scoring system in predicting postoperative morbidity and mortality. World J Surg. 2009;33:80–5. https://doi.org/10.1007/s00268-008-9796-1.
Kartheuser AH, Leonard DF, Penninckx F, et al. Waist circumference and waist/hip ratio are better predictive risk factors for mortality and morbidity after colorectal surgery than body mass index and body surface area. Ann Surg. 2013;258(5):722–30. https://doi.org/10.1097/SLA.0b013e3182a6605a.
McDermott FD, Heeney A, Kelly ME, et al. Systematic review of preoperative, intraoperative and postoperative risk factors for colorectal anastomotic leaks. Br J Surg. 2015;102:462–79. https://doi.org/10.1002/bjs.9697.
Iversen LH, Thomsen GH, Thorlacius-Ussing O. Systemic coagulation activation and anastomotic leakage after colorectal cancer surgery. Dis Colon Rectum. 1999;42:56–65. https://doi.org/10.1007/BF02235183.
Menekse E, Kocer B, Topcu R, et al. A practical scoring system to predict mortality in patients with perforated peptic ulcer. World J EmergSurg. 2015;10:7. https://doi.org/10.1186/s13017-015-0008-7.
Patel S, Kalra D, Kacheriwala S, et al. Validation of prognostic scoring systems for predicting 30-day mortality in perforated peptic ulcer disease. Turk J Surg. 2019;35:252–8. https://doi.org/10.5578/turkjsurg.4211.
Gupta V, Singh SP, Pandey A, et al. Study on the use of t-tube for patients with persistent duodenal fistula: is it useful? World J Surg. 2013;37:2542–5. https://doi.org/10.1007/s00268-013-2196-1.
Boey J, Wong J. Perforated duodenal ulcers. World J Surg. 1987;11:319–24. https://doi.org/10.1007/BF01658109.
Rivai MI, Suchitra A, Janer A. Evaluation of clinical factors and three scoring systems for predicting mortality in perforated peptic ulcer patients, a retrospective study. Ann Med Surg. 2021;69:1027–35. https://doi.org/10.1016/j.amsu.2021.102735.
Irvin TT, Goligher JC. Aetiology of disruption of intestinal anastomoses. Br J Surg. 1973;60:461–4. https://doi.org/10.1002/bjs.1800600612.
Awad S, Abd El-Rahman AI, Abbas A, et al. The assessment of perioperative risk factors of anastomotic leakage after intestinal surgeries; a prospective study. BMC Surg. 2021;21:29. https://doi.org/10.1186/s12893-020-01044-8.
Murugiah L, Mariappan K, Palani M. A study of risk factors influencing anastomotic leakage after small bowel anastomosis. J Evid Based Med Health. 2017;4:2411–8. https://doi.org/10.18410/jebmh/2017/476.
Nair A, Dinker RP, Jagadish S. Predicting anastomotic disruption after emergent small bowel surgery. Dig Surg. 2006;23:38–43. https://doi.org/10.1159/000093493.
Benoist S, Panis Y, Alves A, et al. Impact of obesity on surgical outcomes after colorectal resection. Am J Surg. 2000;179:275–81. https://doi.org/10.1016/s0002-9610(00)00337-8.
Volk A, Kersting S, Held HC, et al. Risk factors for morbidity and mortality after single-layer continuous suture for ileocolonic anastomosis. Int J Colorectal Dis. 2011;2011(26):321–7. https://doi.org/10.1007/s00384-010-1040-4.
Kobold EE, Thal AP. A simple method for the management of experimental wounds of the duodenum. Surg Gynecol Obstet. 1963;1963(116):340–4.
Di Nicola V. Omentum a powerful biological source in regenerative surgery. Regen Ther. 2019;11:182–91. https://doi.org/10.1016/j.reth.2019.07.008.
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Dogra, P., Kaushik, R., Singh, S. et al. Risk factors for leak after omentopexy for duodenal ulcer perforations. Eur J Trauma Emerg Surg 49, 1163–1167 (2023). https://doi.org/10.1007/s00068-022-02058-y
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DOI: https://doi.org/10.1007/s00068-022-02058-y