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Exocrine and endocrine functions and pancreatic volume in patients with pancreatic trauma

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European Journal of Trauma and Emergency Surgery Aims and scope Submit manuscript

Abstract

Introduction

Injury to the pancreas may lead to significant morbidity and mortality. We aim to assess pancreatic endocrine and exocrine functions and evaluated morphological regenerations of pancreas following partial pancreatectomy in patients with pancreatic trauma.

Methods

The study was performed between June 2016 and December 2017. Endocrine functions were assessed at the time of admission and at 6 months follow-up with 75 g oral glucose tolerance test (OGTT), serum insulin and C-peptide levels and HbA1c estimation and exocrine functions were assessed with fecal elastase test. Pancreatic volumetry was done with imaging scan at 1 month and 6 months post discharge.

Results

Twenty patients were studied with a median age of 30 years (range18–48) at the time of injury. All the patients were normoglycemic on admission; only one patient who underwent pancreatic resection developed diabetes mellitus at follow-up. Eight patients (40%) were found to be prediabetic by American Diabetes Association (ADA) criteria. Eleven patients (55%) had pancreatic exocrine insufficiency. Pancreatic volume increment, from the mean pancreatic volume of 48.65 to 54.29 cm3, was noted in patients who underwent partial pancreatectomy.

Conclusions

Patients with pancreatic trauma may develop biochemical endocrine and exocrine insufficiencies following pancreatic resection. Pancreatic volume increment requires further research in a larger study.

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Authors and Affiliations

  1. Division of Trauma Surgery and Critical Care, Department of Surgical Disciplines, JPN Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, 29, India

    Lalchhandami Colney, Sushma Sagar, Amit Gupta & Subodh Kumar

  2. Department of Endocrinology, Diabetes & Metabolism, All India Institute of Medical Sciences, New Delhi, India

    Nikhil Tandon & Nandita Gupta

  3. Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India

    Pramod Kumar Garg

  4. Department of Radiodiagnosis, JPN Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, India

    Atin Kumar

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  1. Lalchhandami Colney
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Contributions

Drs.LC, SK, NT, PKG and AK conceptualized the research, and were involved in execution, analysis, manuscript preparation and final approval of the publication of this work. Drs.SS and AG helped with initial planning, preparation of manuscript and final approval of the publication of this work. Dr.NG helped in the initial planning and supervised the laboratory work of this research and helped in manuscript editing and final approval of the publication of this work.

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Correspondence to Subodh Kumar.

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The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Colney, L., Tandon, N., Garg, P.K. et al. Exocrine and endocrine functions and pancreatic volume in patients with pancreatic trauma. Eur J Trauma Emerg Surg 48, 97–105 (2022). https://doi.org/10.1007/s00068-021-01638-8

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  • DOI: https://doi.org/10.1007/s00068-021-01638-8

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