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Design, synthesis, and anticancer evaluation of 1,2,4-oxadiazole functionalized quinoline derivatives

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Abstract

A library of 1,2,4-oxadiazole functionalized quinoline derivatives (13a–j) were synthesized and their structures were confirmed by 1H NMR, 13CNMR and Mass Spectral analysis. Further, these compounds were evaluated for their anticancer activity against four human cancer cell lines, namely MCF-7 (breast), A549 (lung), DU-145 (prostate) and MDA MB-231 (breast) using Etoposide as the positive control. Most of these derivatives exhibited more potent activity towards the four cancer cell lines compared to Etoposide. Amongst all the compounds tested, compounds 13b, 13c, 13h, 13i and 13j exhibited promising activity. Further of these compounds 13b, 13i and 13j exhibited excellent activity, when compared with Etoposide.

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Authors and Affiliations

  1. Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Andhra Pradesh, 522510, India

    Pruthu Kala, Syed Khasim Sharif & Dittakavi Ramachandran

  2. Department of Chemistry, Adikavi Nannaya University, Rajamahendravaram, Andhra Pradesh, 533296, India

    CH. Murali Krishna

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  1. Pruthu Kala
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  2. Syed Khasim Sharif
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  3. CH. Murali Krishna
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Correspondence to Dittakavi Ramachandran.

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Kala, P., Khasim Sharif, S., Murali Krishna, C. et al. Design, synthesis, and anticancer evaluation of 1,2,4-oxadiazole functionalized quinoline derivatives. Med Chem Res 29, 136–144 (2020). https://doi.org/10.1007/s00044-019-02467-6

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