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Synthesis and antimicrobial evaluation of novel N-substituted 4-ethylsulfanyl-2-pyridones and triazolopyridines

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Abstract

The design and development of new methods for the synthesis of antimicrobial drugs is an important goal currently for medicinal chemistry. Sixteen novel N-substituted-amino-, N-arylsulfonylamino-, and N-aryl-4-ethylsulfanyl-2-pyridones were synthesized. Antimicrobial activities of the compounds were evaluated against four fungal and eight bacterial strains. Antimicrobial results showed that compound 14b had excellent activities as compared to all other newly synthesized compounds and a variety of standard ones against a variety of bacterial and fungal strains. Triazolo[1,5-a]pyridines 10c and 10e showed as well marked activities toward three of the tested Gram-negative bacteria.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Helwan University, Helwan, Cairo, 11795, Egypt

    Rasha A. Azzam & Galal H. Elgemeie

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  1. Rasha A. Azzam
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  2. Galal H. Elgemeie
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Correspondence to Galal H. Elgemeie.

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Azzam, R.A., Elgemeie, G.H. Synthesis and antimicrobial evaluation of novel N-substituted 4-ethylsulfanyl-2-pyridones and triazolopyridines. Med Chem Res 28, 62–70 (2019). https://doi.org/10.1007/s00044-018-2264-z

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  • DOI: https://doi.org/10.1007/s00044-018-2264-z

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