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New aminoadamantane derivatives with antiproliferative activity

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Abstract

1-Benzyl-2-aminoadamantanes 2a–c, conformationally constrained aminoadamantanes 3a, b and 4 and diaminoadamantanes derivatives 5a–c, 6a–c were synthesized and tested as antiproliferative agents. The in vitro biological evaluation showed a significant difference in activity between 1-phenyl and 1-benzyl derivatives.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens, Panepistimioupoli-Zografou, 157 71, Athens, Greece

    Ioannis Papanastasiou, Andrew Tsotinis & Nicolas Kolocouris

  2. Center for Drug Discovery, Northeastern University, 116 Mugar Life Sciences Building, 360 Huntington Avenue, Boston, MA, 02115, USA

    Spyros P. Nikas

  3. Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, 48 Vass. Constantinou, 116 35, Athens, Greece

    Spyros P. Nikas

  4. Anavex Life Sciences, 27 Marathonos Avenue, 153 51, Pallini, Athens, Greece

    Alexandre Vamvakides

Authors
  1. Ioannis Papanastasiou
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  2. Andrew Tsotinis
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  3. Nicolas Kolocouris
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  4. Spyros P. Nikas
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  5. Alexandre Vamvakides
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Correspondence to Ioannis Papanastasiou.

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Papanastasiou, I., Tsotinis, A., Kolocouris, N. et al. New aminoadamantane derivatives with antiproliferative activity. Med Chem Res 23, 1966–1975 (2014). https://doi.org/10.1007/s00044-013-0798-7

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  • DOI: https://doi.org/10.1007/s00044-013-0798-7

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