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Synthesis and Cytotoxic Activity of 1,3,5-Triazinane Derivatives Based on Primary Amines and Amino Acids Esters

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Abstract

A series of 1,3,5-triazinane derivatives was synthesized and their cytotoxic activity was studied in vitro on normal cell line (HEK293) and tumor cell lines (SH-SY5Y, MCF-7, A549). It was shown that the studied compounds have moderate cytotoxic activity against normal and tumor cell lines.

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ACKNOWLEDGMENTS

Spectral studies (NMR spectra and mass spectra) were performed using the equipment of the Center for Collective Use “Chemistry” of the Ufa Institute of Chemistry of the Ufa Federal Research Center of the Russian Academy of Sciences.

Funding

This work was carried out as part of the research work of the Ufa Institute of Chemistry, Ufa Federal Research Center of the Russian Academy of Sciences (registration no. AAAA-A20-120012090031-3).

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Federal Research Center of the Russian Academy of Sciences, 450054, Ufa, Russia

    D. R. Kireeva, S. S. Sadretdinov, A. I. Musina, Yu. I. Murinov & V. A. Dokichev

  2. Institute of Biochemistry and Genetics, Ufa Science Center of the Russian Academy of Sciences, 450054, Ufa, Russia

    D. V. Ishmetova & V. A. Vakhitov

Authors
  1. D. R. Kireeva
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  2. S. S. Sadretdinov
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  3. A. I. Musina
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  4. D. V. Ishmetova
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  5. V. A. Vakhitov
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  6. Yu. I. Murinov
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  7. V. A. Dokichev
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Correspondence to D. R. Kireeva.

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Kireeva, D.R., Sadretdinov, S.S., Musina, A.I. et al. Synthesis and Cytotoxic Activity of 1,3,5-Triazinane Derivatives Based on Primary Amines and Amino Acids Esters. Russ J Gen Chem 92, 24–28 (2022). https://doi.org/10.1134/S1070363222010054

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  • DOI: https://doi.org/10.1134/S1070363222010054

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