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Synthesis of biphenyl derivatives as ACE and α-amylase inhibitors

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Abstract

Angiotensin converting enzyme (ACE) and α-amylase inhibitors were synthesized using 4′-(bromomethyl)-biphenyl-2-carbonitrile 1 and various cyclic secondary amines (a–h). The nitrile group appended to biphenyl was converted into tetrazole 3a–3h and the tetrazole was ring transformed into 1,3,4-oxadiazole derivatives 4a–4h. Some of the compounds have exhibited significant ACE and α-amylase inhibition.

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Fig. 1
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Acknowledgments

We would like to thank the USIC authorities for their help in carrying out the spectral characterization (FT-IR, 1H NMR, MS) and NMR Research Centre, IISc, Bangalore for 13C NMR spectral analyses. We acknowledge the assistance of Biogenics Ltd., Hubballi, Karnataka, India for carrying out the pharmacological properties. The authors acknowledge UGC, New Delhi, Govt. of India for their financial assistance vide letter no. 37-248/2009 (SR). One of the authors (GYM) thanks the UGC, New Delhi for Junior Research Fellowship.

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  1. Department of Studies in Chemistry, Karnatak University, Dharwad, 580003, India

    Gangadhar Yamanappa Meti, Ravindra Ramappa Kamble, Dharesh Bhimaraya Biradar & Sheetal Babu Margankop

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  1. Gangadhar Yamanappa Meti
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  2. Ravindra Ramappa Kamble
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  3. Dharesh Bhimaraya Biradar
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  4. Sheetal Babu Margankop
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Correspondence to Ravindra Ramappa Kamble.

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Meti, G.Y., Kamble, R.R., Biradar, D.B. et al. Synthesis of biphenyl derivatives as ACE and α-amylase inhibitors. Med Chem Res 22, 5868–5877 (2013). https://doi.org/10.1007/s00044-013-0574-8

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