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Synthesis and cytotoxic activity of diaryl urea derivatives with a 4-methylpiperazinylcarbonyl moiety

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Abstract

Eleven diarylurea derivatives (1a–1k) bearing N-methylpiperazinyl moiety were synthesized by the reaction of isocyanate with arylamine. The structures of 1a–1k were characterized by 1H-NMR and MS. The cytotoxic activities of 1a–1k were evaluated via MTT method against human lung adenocarcinoma epithelial cell line A549 and human prostate carcinoma cell line PC3. Compounds 1d and 1k displayed potent cytotoxic activity. The results suggested that the activities are considerably related to the substituent group at another phenyl ring.

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Acknowledgments

Financial support from The National Natural Science Foundation of China (Grant No. 21072156) is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Pharmacy, School of Medicine, Xi’an Jiaotong University, Xi′an, 710061, People’s Republic of China

    Wei Xuan & San-qi Zhang

  2. Institute of Biotherapy, School of Biotechnology, Southern Medical University, Guangzhou, 510515, People’s Republic of China

    Wen Ding & Hong-xiang Hui

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  1. Wei Xuan
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  2. Wen Ding
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  3. Hong-xiang Hui
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  4. San-qi Zhang
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Correspondence to San-qi Zhang.

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Xuan, W., Ding, W., Hui, Hx. et al. Synthesis and cytotoxic activity of diaryl urea derivatives with a 4-methylpiperazinylcarbonyl moiety. Med Chem Res 22, 3857–3862 (2013). https://doi.org/10.1007/s00044-012-0398-y

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  • DOI: https://doi.org/10.1007/s00044-012-0398-y

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