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The in vitro antioxidant properties of the Al-quercetin/βCD and Al-catechin/βCD inclusion compounds, rationalized in terms of their electrochemical behaviour

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Abstract

Inclusion compounds of Al-quercetin and Al-catechin complexes with β-cyclodextrin (βCD) were investigated. The complex and the inclusion compound of quercetin are more effective DPPH• scavengers than the corresponding catechin compounds and the inclusion does not compromise their scavenging abilities, with only a slight decrease in the EC50 values. This is in accordance with the electrochemical data, which revealed that the inclusion compounds have lower diffusion coefficients in aqueous solution than the non-included compounds. For the quercetin compounds, some spectroscopic properties were also addressed by means of UV–visible and NMR measurements in aqueous media.

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Acknowledgments

Acknowledgments are made to Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP) and Conselho Nacional de Desenvolvimento Científico e Tecnológico for financial support. K. D. thank the PhD fellowship from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

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Authors and Affiliations

  1. Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, Ribeirão Preto, SP, 14040-903, Brazil

    Karina Dias & Sofia Nikolaou

  2. Departamento de Química, Faculdade de Filosofia Ciências e Letras de RibeirãoPreto, Universidade de São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, 14040-901, Brazil

    Karina Dias & Wagner F. De Giovani

Authors
  1. Karina Dias
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  2. Sofia Nikolaou
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  3. Wagner F. De Giovani
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Corresponding author

Correspondence to Wagner F. De Giovani.

Electronic supplementary material

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44_2011_9812_MOESM1_ESM.doc

Supplemetary Material 1H NMR spectra of βCD (1.0 mmol L−1) solutions in many ratio of DMSOd 6 in D2O (v: v): 20% DMSOd 6 (a); 50% DMSOd 6 (b) and 80% DMSOd 6 (c). 1H NMR spectra of free βCD (a) and Al-quercetin/βCD (b) inclusion compound, 1.0 mmol L−1, D2O at 25°C. (DOC 100 kb)

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Dias, K., Nikolaou, S. & De Giovani, W.F. The in vitro antioxidant properties of the Al-quercetin/βCD and Al-catechin/βCD inclusion compounds, rationalized in terms of their electrochemical behaviour. Med Chem Res 21, 2920–2925 (2012). https://doi.org/10.1007/s00044-011-9812-0

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  • DOI: https://doi.org/10.1007/s00044-011-9812-0

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