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Novel antitubercular diallyl/dibenzylthiosemicarbazones endowed with high activity toward multi-drug-resistant tuberculosis

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Abstract

Novel diallyl and dibenzylthiosemicarbazones were prepared by three-step reactions. The compounds were tested for their in vitro activity against Mycobacterium tuberculosis H37Rv (MTB) and multi-drug-resistant Mycobacterium tuberculosis (MDR-TB). Most of the compounds showed excellent activity toward MDR-TB. Among the thirty compounds (4,5a–o) tested N,N-dibenzyl-2-((5-nitrofuran-2-yl)methylene)hydrazinecarbothioamide (5g) was found to be the most potent compound MICs of 0.55 and 0.12 μM against MTB and MDR-TB.

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Acknowledgment

The authors are thankful to Department of Biotechnology (BT/01/COE/05/06/01), Government of India for their financial assistances.

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The authors report no conflict of interest. The authors alone are responsible for the content and writing of the article.

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Authors and Affiliations

  1. Medicinal Chemistry & Antimycobacterial Research Laboratory, Pharmacy Group, Birla Institute of Technology & Science—Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad, 500078, Andhra Pradesh, India

    Dharmarajan Sriram, Debjani Banerjee, Tara Sasank Thripuraribhatla Venkata Naga Varuna, Manikandaprabu Sankar & Perumal Yogeeswari

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  1. Dharmarajan Sriram
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  2. Debjani Banerjee
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  3. Tara Sasank Thripuraribhatla Venkata Naga Varuna
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  4. Manikandaprabu Sankar
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  5. Perumal Yogeeswari
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Correspondence to Dharmarajan Sriram.

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Sriram, D., Banerjee, D., Varuna, T.S.T.V.N. et al. Novel antitubercular diallyl/dibenzylthiosemicarbazones endowed with high activity toward multi-drug-resistant tuberculosis. Med Chem Res 21, 810–815 (2012). https://doi.org/10.1007/s00044-011-9638-9

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  • DOI: https://doi.org/10.1007/s00044-011-9638-9

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