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Synthesis, characterization and antimicrobial evaluation of novel derivatives of isoniazid

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Abstract

In the present investigation, a series of new Mannich bases were prepared by the reaction of 2-ethoxybenzaldehyde with isoniazid to form acid hydrazone (3a). Further, C-Mannich bases of the above acid hydrazone were prepared by aminomethylation with formaldehyde and substituted secondary amines (3b–3k). The structures of newly synthesized compounds were evaluated by elemental analyses and spectral (IR, 1H NMR, 13C NMR) studies. All the synthesized compounds were evaluated for their antimicrobial activity. Amoxicillin was used as a standard drug for antibacterial activity while Nystatin was used as a standard drug for antifungal activity. Preliminary pharmacological evaluation revealed that the compound (3f, 3i, 3j, 3k) showed better performance against Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans and Candida gabrata. The result demonstrates the potential and importance of developing new mannich bases which would be effective against resistant bacterial and fungal strain.

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Authors and Affiliations

  1. Research Scholar, Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ferozpur Road, Moga, 142001, Punjab, India

    Manav Malhotra & Sagun Sharma

  2. Department of Pharmaceutical Sciences, G.V.M. College of Pharmacy, Sonepat, 131001, India

    Aakash Deep

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  1. Manav Malhotra
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  2. Sagun Sharma
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  3. Aakash Deep
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Correspondence to Aakash Deep.

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Malhotra, M., Sharma, S. & Deep, A. Synthesis, characterization and antimicrobial evaluation of novel derivatives of isoniazid. Med Chem Res 21, 1237–1244 (2012). https://doi.org/10.1007/s00044-011-9634-0

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  • DOI: https://doi.org/10.1007/s00044-011-9634-0

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