Abstract
Twelve as yet, unreported complexes of luteolin were synthesized with various rare earth ions through refluxing in ethanol. The characterization of these complexes by elemental analysis, infrared spectra, and differential scanning calorimeter demonstrated that luteolin coordinated the various rare earth ions in a similar manner. Experiments designed to study the anti-inflammatory activities of these rare earth-luteolin complexes indicated that they had a significant inhibitory effect on xylene-induced ear edema in mice. Five complexes containing La3+, Ho3+, Yb3+, Lu3+, and Y3+ were equally effective as luteolin and dexamethasone (DXM). However, their inhibitory effects on carrageenan-induced paw edema in mice, although significant, were weaker than that of either luteolin alone or DXM.
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This work was supported by the Natural Science Foundation of Zhejiang Province (Y205706).
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Li, J., Wang, L., Bai, H. et al. Synthesis, characterization, and anti-inflammatory activities of rare earth metal complexes of luteolin. Med Chem Res 20, 88–92 (2011). https://doi.org/10.1007/s00044-009-9289-2
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DOI: https://doi.org/10.1007/s00044-009-9289-2