Abstract
A series of novel 1,2,4-triazole derivatives have been synthesized by condensing the methyl benzoate and methyl salicylate with various substituents; their structures were established on the basis of elemental analysis, Fourier transform infrared spectroscopy (FTIR), 1H nuclear magnetic resonance (NMR), and mass spectral data. All title compounds were subjected to in vitro antibacterial and antifungal screening against four different bacterial and fungal strains. Preliminary results indicate that some of them exhibit promising activities and deserve further consideration as potential antimicrobials.
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Acknowledgments
The authors are grateful to the Head of the School of Pharmacy, Devi Ahilya Vishwavidyalay, Indore, Madhya Pradesh, India and Sophisticated Analytical Instrument Facility, Central Drug Research Institute, Lucknow, India for elemental analysis, 1H NMR, and mass spectral data of the synthesized compounds reported herein. One of the authors, Mr. Priyabrata Pattanayak, is grateful to the All India Council of Technical Education (AICTE) for providing financial aid.
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Sahoo, P.K., Sharma, R. & Pattanayak, P. Synthesis and evaluation of 4-amino-5-phenyl-4H-[1,2,4]-triazole-3-thiol derivatives as antimicrobial agents. Med Chem Res 19, 127–135 (2010). https://doi.org/10.1007/s00044-009-9178-8
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DOI: https://doi.org/10.1007/s00044-009-9178-8