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Amino steroids as antimalarial agents

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Abstract

Using easily accessible deoxycholic acid as the starting material, amino compounds 8a-e and 9a-c were prepared and screened against P. falciparum in vitro. Amino steroid 8d was the most active of the series with a minimum inhibiting concentration (MIC) of 0.5 μg/mL.

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References

  • Abdel-Magid AF, Carson KG, Harris BD, Maryanoff CA, Shah RD (1996) Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. Studies on direct and indirect reductive amination procedures. J Org Chem 61:3849–3862

    Article  PubMed  CAS  Google Scholar 

  • Bloland BP (2001) Drug Resistance in Malaria, WHO, Geneva. Report no. WHO/CDS/CSR/DRS/2001.4

  • Lambros C, Vanderberg JP (1979) Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol 65:418–420

    Article  PubMed  CAS  Google Scholar 

  • Moretti C, Sauvain M, Lavaud C, Massiot G, Bravo JA, Munoz V (1998) A novel antiprotozoal aminosteroid from Saracha punctata. J Nat Prod 61:1390–1393

    Article  PubMed  CAS  Google Scholar 

  • Oishi T, Tsuchikawa H, Murata M, Yoshida M, Morisawa M (2004) Synthesis and identification of an endogenous sperm activating and attracting factor isolated from eggs of the ascidian Ciona intestinalis, an example of nanomolar-level structure elucidation of novel natural compound. Tetrahedron 60:6971–6980

    Article  CAS  Google Scholar 

  • Ridley RG (2002) Medical need, scientific opportunity and the drive for antimalarial drugs. Nature 415:686–693

    Article  PubMed  CAS  Google Scholar 

  • Rieckmann KH, Campbell GH, Sax LJ, Mrema JE (1978) Drug sensitivity of plasmodium falciparum. An in-vitro microtechnique. Lancet 1:22–23

    Article  PubMed  CAS  Google Scholar 

  • Vaidya AS, Dixit SM, Rao AS (1968) Degradation of bile acid side chain with lead tetraacetate. Tet Lett 50:5173–5174

    Article  CAS  Google Scholar 

  • Wellems J, Plowe C (2001) Chloroquine-resistant malaria. J Infec Dis 184:770–776

    Article  CAS  Google Scholar 

  • Wiesner J, Ortmann R, Jomaa H, Schlitzer M (2003) New antimalarial drugs. Angew Chem Int Ed 42: 5274–5293

    Article  CAS  Google Scholar 

  • WHO (1999) Drug Information Bulletin 13:9

    Google Scholar 

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Acknowledgment

Upasana Sharma is grateful to the Council of Scientific and Industrial Research (CSIR), New Delhi for the award of a Senior Research Fellowship.

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Authors and Affiliations

  1. Division of Medicinal & Process Chemistry, Central Drug Research Institute, Lucknow, 226001, India

    Upasana Sharma & Chandan Singh

  2. Division of Parasitology, Central Drug Research Institute, Lucknow, 226001, India

    Kumkum Srivastava & Sunil K. Puri

Authors
  1. Upasana Sharma
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  2. Kumkum Srivastava
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  3. Sunil K. Puri
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  4. Chandan Singh
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Correspondence to Chandan Singh.

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Sharma, U., Srivastava, K., Puri, S.K. et al. Amino steroids as antimalarial agents. Med Chem Res 17, 326–334 (2008). https://doi.org/10.1007/s00044-007-9068-x

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  • DOI: https://doi.org/10.1007/s00044-007-9068-x

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