Abstract.
This review focuses on recent papers that describe the involvement of the RGD sequence in bone biology and incorporate the use of synthetic RGD peptides to develop new drugs or control the bioactivity of materials used for bone regeneration. Because in vivo bone function is completely dependent on angiogenesis and vessels, the present publication is focused on physiology, pathophysiology and therapeutics of RGD peptides dedicated to bone cells and endothelial systems. It appears that αVβ3, αVβ5 and αIIb β3 are the integrins most reported to be involved in bone function and RGD sequence binding. The specificity of RGD peptides depends on backbone conformation, orientations of the charged side chains of Arg and Asp residues, and hydrophobic moieties flanking the Asp residue. Despite of recent progress in integrins and RGD peptide structures and function, future work should focus on integrin selectivity of RGD-based agents, model structure and activity-selectivity relationships.
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Received 5 June 2002; received after revision 8 July 2002; accepted 23 July 2002
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Schaffner, P., Dard, M. Structure and function of RGD peptides involved in bone biology. CMLS, Cell. Mol. Life Sci. 60, 119–132 (2003). https://doi.org/10.1007/s000180300008
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DOI: https://doi.org/10.1007/s000180300008