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Regulation of energy metabolism in human pluripotent stem cells

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Abstract

All living organisms need energy to carry out their essential functions. The importance of energy metabolism is increasingly recognized in human pluripotent stem cells. Energy production is not only essential for cell survival and proliferation, but also critical for pluripotency and cell fate determination. Thus, energy metabolism is an important target in cellular regulation and stem cell applications. In this review, we will discuss key factors that influence energy metabolism and their association with stem cell functions.

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Acknowledgements

We thank the council members of Macau Society for Stem Cell Research (MSSCR) for the constructive discussions.

Funding

This work was supported by the University of Macau (File No. MYRG2018-00135-FHS and MYRG2019-00147-FHS), and also by the Science and Technology Development Fund, Macau SAR (File No. 0059/2019/A1, 0123/2019/A3 and 0011/2019/AKP).

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  1. Faculty of Health Sciences, Centre of Reproduction, Development and Aging, University of Macau, Taipa, Macau SAR, China

    Weiwei Liu & Guokai Chen

  2. Bioimaging and Stem Cell Core Facility, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China

    Weiwei Liu

  3. MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, China

    Guokai Chen

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  1. Weiwei Liu
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Both authors conceptualized and drafted the article. WL designed the figures. Both authors have read and agreed to the final version of the manuscript.

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Correspondence to Guokai Chen.

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Liu, W., Chen, G. Regulation of energy metabolism in human pluripotent stem cells. Cell. Mol. Life Sci. 78, 8097–8108 (2021). https://doi.org/10.1007/s00018-021-04016-0

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