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P53 vs NF-κB: the role of nuclear factor-kappa B in the regulation of p53 activity and vice versa

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Abstract

The onco-suppressor p53 is a transcription factor that regulates a wide spectrum of genes involved in various cellular functions including apoptosis, cell cycle arrest, senescence, autophagy, DNA repair and angiogenesis. p53 and NF-κB generally have opposing effects in cancer cells. While p53 activity is associated with apoptosis induction, the stimulation of NF-κB has been demonstrated to promote resistance to programmed cell death. Although the transcription factor NF-κB family is considered as the master regulator of cancer development and maintenance, it has been mainly studied in relation to its ability to regulate p53. This has revealed the importance of the crosstalk between NF-κB, p53 and other crucial cell signaling pathways. This review analyzes the various mechanisms by which NF-κB regulates the activity of p53 and the role of p53 on NF-κB activity.

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Acknowledgments

We thank the Dept. of Clinical and Biological Science for funding our research (Ex-60 grant). Italian Association for Cancer Research Star-Up Grant-15405 to RT.

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  1. Giovanna Carrà, Marcello Francesco Lingua equally contribute to the work.

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  1. Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043, Orbassano, Italy

    Giovanna Carrà, Beatrice Maffeo & Alessandro Morotti

  2. Department of Oncology, University of Turin, Regione Gonzole 10, 10043, Orbassano, Italy

    Marcello Francesco Lingua & Riccardo Taulli

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  1. Giovanna Carrà
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  2. Marcello Francesco Lingua
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GC and MFL wrote the manuscript and generated the figures. BM helped in the preparation of the manuscript. RT and AM reviewed the manuscript.

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Correspondence to Giovanna Carrà or Alessandro Morotti.

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Carrà, G., Lingua, M.F., Maffeo, B. et al. P53 vs NF-κB: the role of nuclear factor-kappa B in the regulation of p53 activity and vice versa. Cell. Mol. Life Sci. 77, 4449–4458 (2020). https://doi.org/10.1007/s00018-020-03524-9

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