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What tangled webs they weave: Rho-GTPase control of angiogenesis

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Abstract.

The members of the Rho family of small GTPases are involved in an array of cellular processes, including regulation of the actin cytoskeleton, cell polarity, microtubule dynamics, membrane transport, and transcription factor activity. Recent findings have implicated the Rho-proteins as key regulators of angiogenesis, modulating a diversity of cellular processes, including vascular permeability, extracellular matrix remodeling, migration, proliferation, morphogenesis, and survival.

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Authors and Affiliations

  1. Schepens Eye Research Institute, 20 Staniford Street, Boston, 02114, USA

    B. A. Bryan & P. A. D’Amore

  2. Departments of Ophthalmology and Pathology, Harvard Medical School, Boston, Massachusetts, USA

    B. A. Bryan & P. A. D’Amore

Authors
  1. B. A. Bryan
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  2. P. A. D’Amore
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Correspondence to P. A. D’Amore.

Additional information

Received 8 January 2007; received after revision 21 March 2007; accepted 16 April 2007

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Bryan, B.A., D’Amore, P.A. What tangled webs they weave: Rho-GTPase control of angiogenesis. Cell. Mol. Life Sci. 64, 2053–2065 (2007). https://doi.org/10.1007/s00018-007-7008-z

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  • DOI: https://doi.org/10.1007/s00018-007-7008-z

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