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Genetic Factors of Diabetes

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Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

Monogenic diabetes is a rare genetic type of diabetes caused by pancreatic β-cells dysfunction. All subtypes of monogenic diabetes are recognized in the pediatric population. They include maturity onset diabetes of the young, permanent neonatal diabetes mellitus and rare syndromic forms of diabetes. An early and proper diagnosis allows to implement an optimal treatment, leads to improved metabolic control and amelioration of related disabilities as well as increases the quality of life of the patients.

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Abbreviations

AS:

Alström syndrome

DEND:

Developmental delay, epilepsy and neonatal diabetes syndrome

GCK :

Glucokinase

HNF1A :

Hepatocyte nuclear factor-1-alpha

HNF1B :

Hepatocyte nuclear factor-1-beta

HNF4A :

Hepatocyte nuclear factor-4-alpha

i-DEND:

Intermediate developmental delay, epilepsy and neonatal diabetes syndrome

MODY:

Maturity onset diabetes of the young

NGS:

Next-generation sequencing

PDX1 :

Pancreas/duodenum homeobox protein

PNDM:

Permanent neonatal diabetes mellitus

WFS:

Wolfram syndrome

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Acknowledgements

This work was supported by funds from the National Science Centre, Project No. 2011/01/N/NZ5/02758 and 2013/09/B/NZ5/00779.

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Authors and Affiliations

  1. Department of Clinical Genetics, Medical University of Lodz, Pomorska 251, 92-213, Lodz, Poland

    Karolina Antosik & Maciej Borowiec

Authors
  1. Karolina Antosik
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  2. Maciej Borowiec
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Correspondence to Maciej Borowiec.

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Antosik, K., Borowiec, M. Genetic Factors of Diabetes. Arch. Immunol. Ther. Exp. 64 (Suppl 1), 157–160 (2016). https://doi.org/10.1007/s00005-016-0432-8

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