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Intercellular Exchange of Surface Molecules and its Physiological Relevance

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Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

For many decades, cellular immunologists have relied on the expression of various cell surface molecules to divide cells into different types and subtypes to study their function. However, in recent years, a large and fast-expanding body of work has described the transfer of surface molecules, including MHC class I and II molecules, between cells, both in vitro and in vivo. The function of this process is still largely unknown, but it is likely to have a significant role in the control of the immune system. It is also likely that this process takes place in a regulated rather than stochastic manner, thus providing another way for the immune system to orchestrate its function. In this review we will summarize the key findings so far, examining the mechanisms of transfer, the consequences of this transfer as shown by in vitro experiments, and possible consequences for the wider immune response.

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Abbreviations

MHC:

Major histocompatibility complex

DC:

Dendritic cell

APC:

Antigen-presenting cell

MICA:

MHC (HLA) class I chain-related gene A

ICAM-1:

Intercellular adhesion molecule 1

LFA-1:

Lymphocyte function-associated antigen 1

NK:

Natural killer

SMAC:

Supramolecular activation cluster

SMIC:

Supramolecular inhibition cluster

TcR:

T cell receptor

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Acknowledgments

Work in the authors’ laboratory relating to this review article is supported by the Genzyme Renal innovative program. M. Fidanboylu is the recipient of a BBSRC integrated mammalian physiology PhD studentship.

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  1. MRC Centre for Transplantation, King’s College London, School of Medicine at Guy’s, King’s and St. Thomas’ Hospitals, London, UK

    Kathryn Brown, Mehmet Fidanboylu & Wilson Wong

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  1. Kathryn Brown
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  2. Mehmet Fidanboylu
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  3. Wilson Wong
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Correspondence to Wilson Wong.

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Brown, K., Fidanboylu, M. & Wong, W. Intercellular Exchange of Surface Molecules and its Physiological Relevance. Arch. Immunol. Ther. Exp. 58, 263–272 (2010). https://doi.org/10.1007/s00005-010-0085-y

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