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Overview of the Immune Response

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Abstract

This chapter introduces the components of the immune response that includes differences in innate and acquired immune systems and their differences. Specifically, physical, chemical, and cellular barriers, complement system, and Toll-like receptors are discussed in reference to the innate immune system, whereas humoral and cell-mediated responses are described when explaining the acquired/adoptive immune response. The details include the different isotypes of antibodies involved in humoral immune response and various types of cells that participate in humoral versus cell-mediated immune responses. Additionally, the concepts of antigen recognition, antigen presentation, and molecules involved in these processes, including the major histocompatibility complex, are described. Lastly, mechanisms of cellular migration and immune tolerance are discussed. The emphasis is that how the immune system recognizes and responds to the invading pathogens and what type of system is in place and sequentially develops to perform these tasks.

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  1. Pharmacy Sciences, Creighton University, Omaha, Nebraska, USA

    Manzoor M. Khan

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Khan, M.M. (2016). Overview of the Immune Response. In: Immunopharmacology. Springer, Cham. https://doi.org/10.1007/978-3-319-30273-7_1

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