Abstract
Serum copper concentration increases significantly (p<0.01) in rats with experimental atherosclerosis compared to a control group. The serum zinc, the zinc, and copper concentration in abdominal aorta and in liver decreases significantly (p<0.05) compared to the control group. Administration of copper sulfate for 100 d in these animals induces a significant increase of serum copper (p<0.01), decrease of serum cholesterol (p<0.05) and increase of liver copper concentration as compared with the group fed only a high cholesterol diet. In the aorta of these animals the copper concentration increases and edema and lipid infiltration are considerably less than in the group of animals fed only a high lipid diet.
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Vlad, M., Bordas, E., Tomus, R. et al. Effect of copper sulfate on experimental atherosclerosis. Biol Trace Elem Res 38, 47–54 (1993). https://doi.org/10.1007/BF02783981
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DOI: https://doi.org/10.1007/BF02783981