Abstract
The pharmacokinetic profile of carbamazepine was studied in six normal humans after single and repeated oral doses. The plasma concentrations following single dose (100, 200, 600 mg) were fitted by a one-compartment open model. Using area as a measure, availability was constant in the dose range studied. The elimination half-life ± SEafter a single dose was 37.7±5.7hr; it decreased during chronic treatment to a calculated value around 21 hr. The steady-state plasma concentration, lower than expected from the single-dose study, was adequately predicted from the single-dose data when a correction was made for the increased elimination rate constant. The present findings contrast with the apparently unpredictable plasma levels reported during carbamazepine therapy.
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Gérardin, A.P., Abadie, F.V., Campestrini, J.A. et al. Pharmacokinetics of carbamazepine in normal humans after single and repeated oral doses. Journal of Pharmacokinetics and Biopharmaceutics 4, 521–535 (1976). https://doi.org/10.1007/BF01064556
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DOI: https://doi.org/10.1007/BF01064556