Abstract
The reserves of fossil-based fuels, which currently seem sufficient to meet the global demands, is inevitably on the verge of exhaustion. Contemporary raw material for alternate fuel like biodiesel is usually edible plant commodity oils, whose increasing public consumption rate raises the need of finding a non-edible and fungible alternate oil source. In this quest, single cell oils (SCO) from oleaginous yeasts and fungi can provide a sustainable alternate of not only functional but also valuable (polyunsaturated fatty acids (PUFA)-rich) lipids. Researches are been increasingly driven towards increasing the SCO yield in order to realize its commercial importance. However, bulk requirement of expensive synthetic carbon substrate, which inflates the overall SCO production cost, is the major limitation towards complete acceptance of this technology. Even though substrate cost minimization could make the SCO production profitable is uncertain, it is still essential to identify suitable cheap and abundant substrates in an attempt to potentially reduce the overall process economy. One of the most sought-after in-expensive carbon reservoirs, agro-industrial wastes, can be an attractive replacement to expensive synthetic carbon substrates in this regard. The present review assess these possibilities referring to the current experimental investigations on oleaginous yeasts, and fungi reported for conversion of agro-industrial feedstocks into triacylglycerols (TAGs) and PUFA-rich lipids. Multiple associated factors regulating lipid accumulation utilizing such substrates and impeding challenges has been analyzed. The review infers that production of bulk oil in combination to high-value fatty acids, co-production strategies for SCO and different microbial metabolites, and reutilization and value addition to spent wastes could possibly leverage the high operating costs and help in commencing a successful biorefinery. Rigorous research is nevertheless required whether it is PUFA-rich oil production (for competing with algal omega oils) or neutral bulk oil production (for overcoming yield limitations and managing process economy) to establish this potential source as future resource.
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References
Addison K (2001) Journey to forever. Home made projects. http://journeytoforever.org/biodiesel_yield.html. Accessed 20 Sept 2016
Agbogbo FK, Coward-Kelly G (2008) Cellulosic ethanol production using the naturally occurring xylose-fermenting yeast, Pichia stipitis. Biotechnol Lett 30:1515–1524. https://doi.org/10.1007/s10529-008-9728-z
Angerbauer C, Siebenhofer M, Mittelbach M, Guebitz G (2008) Conversion of sewage sludge into lipids by Lipomyces starkeyi for biodiesel production. Bioresour Technol 99:3051–3056. https://doi.org/10.1016/j.biortech.2007.06.045
Athalye SK, Garcia RA, Wen Z (2009) Use of biodiesel-derived crude glycerol for producing eicosapentaenoic acid (EPA) by the fungus Pythium irregulare. J Agric Food Chem 57:2739–2744. https://doi.org/10.1021/jf803922w
Bellou S, Triantaphyllidou I-E, Aggeli D, Elazzazy AM, Baeshen MN, Aggelis G (2016) Microbial oils as food additives: recent approaches for improving microbial oil production and its polyunsaturated fatty acid content. Curr Opin Biotechnol 37:24–35. https://doi.org/10.1016/j.copbio.2015.09.005
Berłowska J, Pielech-Przybylska K, Balcerek M, Dziekońska-Kubczak U, Patelski P, Dziugan P, Kręgiel D (2016) Simultaneous saccharification and fermentation of sugar beet pulp for efficient bioethanol production. Biomed Res Int 2016:1–10. https://doi.org/10.1155/2016/3154929
Bettiga M, Bengtsson O, Hahn-Hägerdal B, Gorwa-Grauslund MF (2009) Arabinose and xylose fermentation by recombinant Saccharomyces cerevisiae expressing a fungal pentose utilization pathway. Microb Cell Factories 8(1):40. https://doi.org/10.1186/1475-2859-8-40
Blasi D, Drouillard J, Titgemeyer E, Paisley S, Brouk M (2000) Soybean hulls composition and feed value for beef and dairy cattle. Kansas State Univ Document 00-79-E
Boulton CA (1988) The biotechnology of microbial oils and fats. In: Resources and applications of biotechnology. Springer, pp 131–140. https://doi.org/10.1007/978-1-349-09574-2_14
Boulton CA, Ratledge C (1981) Correlation of lipid accumulation in yeasts with possession of ATP: citrate lyase. Microbiology 127:169–176. https://doi.org/10.1099/00221287-127-1-169
Bowles R, Hunt A, Bremer G, Duchars M, Eaton R (1999) Long-chain n− 3 polyunsaturated fatty acid production by members of the marine protistan group the thraustochytrids: screening of isolates and optimisation of docosahexaenoic acid production. J Biotechnol 70:193–202. https://doi.org/10.1016/j.biotechadv.2012.02.014
Čertík M, Adamechová Z, Guothová L (2013) Simultaneous enrichment of cereals with polyunsaturated fatty acids and pigments by fungal solid state fermentations. J Biotechnol 168:130–134. https://doi.org/10.1016/j.jbiotec.2013.03.016
Certik M, Shimizu S (1999) Biosynthesis and regulation of microbial polyunsaturated fatty acid production. J Biosci Bioeng 87:1–14. https://doi.org/10.1016/S1389-1723(99)80001-2
Chang Y-H, Chang K-S, Lee C-F, Hsu C-L, Huang C-W, Jang H-D (2015) Microbial lipid production by oleaginous yeast Cryptococcus sp. in the batch cultures using corncob hydrolysate as carbon source. Biomass Bioenergy 72:95–103. https://doi.org/10.1016/j.biombioe.2014.11.012
Chen X-F, Huang C, Xiong L, Chen Y, Ma L-l (2012) Oil production on wastewaters after butanol fermentation by oleaginous yeast Trichosporon coremiiforme. Bioresour Technol 118:594–597. https://doi.org/10.1016/j.biortech.2012.05.023
Chen X-F, Huang C, Yang X-Y, Xiong L, Chen X-D, Ma L-L (2013) Evaluating the effect of medium composition and fermentation condition on the microbial oil production by Trichosporon cutaneum on corncob acid hydrolysate. Bioresour Technol 143:18–24. https://doi.org/10.1016/j.biortech.2013.05.102
Cheng K-K, Cai B-Y, Zhang J-A, Ling H-Z, Zhou Y-J, Ge J-P, Xu J-M (2008) Sugarcane bagasse hemicellulose hydrolysate for ethanol production by acid recovery process. Biochem Eng J 38:105–109. https://doi.org/10.1016/j.bej.2007.07.012
Cripps R et al (2009) Metabolic engineering of Geobacillus thermoglucosidasius for high yield ethanol production. Metab Eng 11:398–408. https://doi.org/10.1016/j.ymben.2009.08.005
Deeba F, Pruthi V, Negi YS (2016) Converting paper mill sludge into neutral lipids by oleaginous yeast Cryptococcus vishniaccii for biodiesel production. Bioresour Technol 213:96–102. https://doi.org/10.1016/j.biortech.2016.02.105
Diwan B, Parkhey P, Gupta P (2018) Platform study on development of a non-detoxified rice straw hydrolysate to its application in lipid production from Mortierella alpina. ACS Sustain Chem Eng 6:1225–1234. https://doi.org/10.1021/acssuschemeng.7b03530
Economou CN, Aggelis G, Pavlou S, Vayenas D (2011) Single cell oil production from rice hulls hydrolysate. Bioresour Technol 102:9737–9742. https://doi.org/10.1016/j.biortech.2011.08.025
Economou CN, Makri A, Aggelis G, Pavlou S, Vayenas D (2010) Semi-solid state fermentation of sweet sorghum for the biotechnological production of single cell oil. Bioresour Technol 101:1385–1388. https://doi.org/10.1016/j.biortech.2009.09.028
Economou CN, Marinakis N, Moustaka-Gouni M, Kehayias G, Aggelis G, Vayenas DV (2015) Lipid production by the filamentous Cyanobacterium Limnothrix sp. growing in synthetic wastewater in suspended-and attached-growth photobioreactor systems. Anna Microbiol 65:1941–1948. https://doi.org/10.1007/s13213-014-1032-7
Fakas S, Čertik M, Papanikolaou S, Aggelis G, Komaitis M, Galiotou-Panayotou M (2008) γ-linolenic acid production by Cunninghamella echinulata growing on complex organic nitrogen sources. Bioresour Technol 99:5986–5990. https://doi.org/10.1016/j.biortech.2007.10.016
Fakas S, Makri A, Mavromati M, Tselepi M, Aggelis G (2009a) Fatty acid composition in lipid fractions lengthwise the mycelium of Mortierella isabellina and lipid production by solid state fermentation. Bioresour Technol 100:6118–6120. https://doi.org/10.1016/j.biortech.2009.06.015
Fakas S, Papanikolaou S, Batsos A, Galiotou-Panayotou M, Mallouchos A, Aggelis G (2009b) Evaluating renewable carbon sources as substrates for single cell oil production by Cunninghamella echinulata and Mortierella isabellina. Biomass Bioenergy 33:573–580. https://doi.org/10.1016/j.biombioe.2008.09.006
Fan K, Chen F, Jones EB, Vrijmoed LL (2001) Eicosapentaenoic and docosahexaenoic acids production by and okara-utilizing potential of thraustochytrids. J Ind Microbiol Biotechnol 27:199–202. https://doi.org/10.1038/sj.jim.7000169
Freitas C, Parreira TM, Roseiro J, Reis A, da Silva TL (2014) Selecting low-cost carbon sources for carotenoid and lipid production by the pink yeast Rhodosporidium toruloides NCYC 921 using flow cytometry. Bioresour Technol 158:355–359. https://doi.org/10.1016/j.biortech.2014.02.071
Gao Q, Cui Z, Zhang J, Bao J (2014) Lipid fermentation of corncob residues hydrolysate by oleaginous yeast Trichosporon cutaneum. Bioresour Technol 152:552–556. https://doi.org/10.1016/j.biortech.2013.11.044
Gema H, Kavadia A, Dimou D, Tsagou V, Komaitis M, Aggelis G (2002) Production of γ-linolenic acid by Cunninghamella echinulata cultivated on glucose and orange peel. Appl Microbiol Biotechnol 58:303–307. https://doi.org/10.1007/s00253-001-0910-7
Gerster H (1998) Can adults adequately convert a-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)? Int J Vitam Nutr Res 68:159–173
Ghobadi Z, Hamidi-Esfahani Z, Azizi M (2011) Determination of effective variables on arachidonic acid production by Mortierella alpina CBS 754.68 in solid-state fermentation using Plackett-Burman screening design. World Acad Sci Eng Technol 81:678–680
Gong Z, Shen H, Wang Q, Yang X, Xie H, Zhao ZK (2013) Efficient conversion of biomass into lipids by using the simultaneous saccharification and enhanced lipid production process. Biotechnol Biofuels 6:1–11. https://doi.org/10.1186/1754-6834-6-36
Gong Z, Wang Q, Shen H, Wang L, Xie H, Zhao ZK (2014) Conversion of biomass-derived oligosaccharides into lipids. Biotechnol Biofuels 7:13. https://doi.org/10.1186/1754-6834-7-13
Gupta A, Abraham RE, Barrow CJ, Puri M (2015) Omega-3 fatty acid production from enzyme saccharified hemp hydrolysate using a novel marine thraustochytrid strain. Bioresour Technol 184:373–378. https://doi.org/10.1016/j.biortech.2014.11.031
Gupta P, Parkhey P (2014) A two-step process for efficient enzymatic saccharification of rice straw. Bioresour Technol 173:207–215. https://doi.org/10.1016/j.biortech.2014.09.101
Gupta P, Parkhey P (2015) Design of a single chambered microbial electrolytic cell reactor for production of biohydrogen from rice straw hydrolysate. Biotechnol Lett 37:1213–1219. https://doi.org/10.1007/s10529-015-1780-x
Hsiao TY, Glatz CE, Glatz BA (1994) Broth recycle in a yeast fermentation. Biotechnol Bioeng 44:1228–1234. https://doi.org/10.1002/bit.260441010
Huang C, Chen X-F, Xiong L, Yang X-Y, Ma L-L, Chen Y (2013) Microbial oil production from corncob acid hydrolysate by oleaginous yeast Trichosporon coremiiforme. Biomass Bioenergy 49:273–278. https://doi.org/10.1016/j.biombioe.2012.12.023
Huang C, X-x C, Wu H, W-y L, Zong M-h (2014) The effect of different factors on microbial oil production by Trichosporon fermentans on rice straw acid hydrolysate. Int J Green Energy 11:787–795. https://doi.org/10.1080/15435075.2013.829779
Huang C, Wu H, Li R-f, Zong M-h (2012) Improving lipid production from bagasse hydrolysate with Trichosporon fermentans by response surface methodology. New Biotechnol 29:372–378. https://doi.org/10.1016/j.nbt.2011.03.008
Huang C, Wu H, Q-p L, Li Y-y, Zong M-h (2011) Effects of aldehydes on the growth and lipid accumulation of oleaginous yeast Trichosporon fermentans. J Agric Food Chem 59:4606–4613. https://doi.org/10.1021/jf104320b
Huang C, Zong M-h, Wu H, Q-p L (2009) Microbial oil production from rice straw hydrolysate by Trichosporon fermentans. Bioresour Technol 100:4535–4538. https://doi.org/10.1016/j.biortech.2009.04.022
Hui L, Wan C, Hai-Tao D, Xue-Jiao C, Qi-Fa Z, Yu-Hua Z (2010) Direct microbial conversion of wheat straw into lipid by a cellulolytic fungus of Aspergillus oryzae A-4 in solid-state fermentation. Bioresour Technol 101:7556–7562. https://doi.org/10.1016/j.biortech.2010.04.027
Hwan Seo Y, Gyu Lee I, In Han J (2013) Cultivation and lipid production of yeast Cryptococcus curvatus using pretreated waste active sludge supernatant. Bioresour Technol 135:304–308. https://doi.org/10.1016/j.biortech.2012.10.024
Ito T, Nakashimada Y, Senba K, Matsui T, Nishio N (2005) Hydrogen and ethanol production from glycerol-containing wastes discharged after biodiesel manufacturing process. J Biosci Bioeng 100:260–265. https://doi.org/10.1263/jbb.100.260
Jacobs A, Botha A, Van Zyl WH (2009) The production of eicosapentaenoic acid by representatives of the genus Mortierella grown on brewers’ spent grain. Biologia 64:871–876. https://doi.org/10.2478/s11756-009-0152-1
Jacobs A, Botha A, Van Zyl WH (2010) Sunflower press cake as a substrate for eicosapentaenoic acid production by representatives of the genus Mortierella. Bioresources 5:1232–1243
Jin M, Slininger PJ, Dien BS, Waghmode S, Moser BR, Orjuela A, Sousa LC, Balan V (2015) Microbial lipid-based lignocellulosic biorefinery: feasibility and challenges. Trends Biotechnol 33:43–54. https://doi.org/10.1016/j.tibtech.2014.11.005
Karatay SE, Dönmez G (2010) Improving the lipid accumulation properties of the yeast cells for biodiesel production using molasses. Bioresour Technol 101:7988–7990. https://doi.org/10.1016/j.biortech.2010.05.054
Kim JW, Park TJ, Ryu DD, Kim JY (2000) High cell density culture of Yarrowia lipolytica using a one step feeding process. Biotechnol Prog 16:657–660. https://doi.org/10.1021/bp000037n
Koopmans A, Koppejan J (1997) Agricultural and forest residues-generation, utilization and availability. Regional consultation on modern applications of biomass energy, In, p 10
Kosa M, Ragauskas AJ (2012) Bioconversion of lignin model compounds with oleaginous Rhodococci. Appl Microbiol Biotechnol 93:891–900. https://doi.org/10.1007/s00253-011-3743-z
Kosa M, Ragauskas AJ (2013) Lignin to lipid bioconversion by oleaginous Rhodococci. Green Chem 15:2070–2074. https://doi.org/10.1039/C3GC40434J
Koutinas AA, Chatzifragkou A, Kopsahelis N, Papanikolaou S, Kookos IK (2014) Design and techno-economic evaluation of microbial oil production as a renewable resource for biodiesel and oleochemical production. Fuel 116:566–577. https://doi.org/10.1016/j.fuel.2013.08.045
Kumar P, Barrett DM, Delwiche MJ, Stroeve P (2009) Methods for pretreatment of lignocellulosic biomass for efficient hydrolysis and biofuel production. Ind Eng Chem Res 48:3713–3729. https://doi.org/10.1021/ie801542g
Leman J (1997) Oleaginous microorganisms: an assessment of the potential. Adv Appl Microbiol 43:195–243
Li S, Zhu D, Li K, Yang Y, Lei Z, Zhang Z (2013) Soybean curd residue: composition, utilization, and related limiting factors. ISRN Ind Eng 2013
Li X, Park A, Estrela R, Kim S-R, Jin Y-S, Cate JH (2016) Comparison of xylose fermentation by two high-performance engineered strains of Saccharomyces cerevisiae. Biotechnol Rep 9:53–56. https://doi.org/10.1016/j.btre.2016.01.003
Mateo-Sagasta J, Raschid-Sally L, Thebo A (2015) Global wastewater and sludge production, treatment and use. In: Drechsel P, Qadir M, Wichelns D (eds) Wastewater. Springer, pp 15–38. https://doi.org/10.1007/978-94-017-9545-6
Merendino N, Costantini L, Manzi L, Molinari R, D'Eliseo D, Velotti F (2013) Dietary ω-3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer. Biomed Res Int 2013:1–11. https://doi.org/10.1155/2013/310186
Munch G, Sestric R, Sparling R, Levin DB, Cicek N (2015) Lipid production in the under-characterized oleaginous yeasts, Rhodosporidium babjevae and Rhodosporidium diobovatum, from biodiesel-derived waste glycerol. Bioresour Technol 185:49–55. https://doi.org/10.1016/j.biortech.2015.02.051
Muniraj IK, Xiao L, Hu Z, Zhan X, Shi J (2013) Microbial lipid production from potato processing wastewater using oleaginous filamentous fungi Aspergillus oryzae. Water Res 47:3477–3483. https://doi.org/10.1016/j.watres.2013.03.046
Nguyen V et al (2016) Generating a positive energy balance from using rice straw for anaerobic digestion. Energy Reports 2:117–122. https://doi.org/10.1016/j.egyr.2016.05.005
Pagana I, Morawicki R, Hager TJ (2014) Lactic acid production using waste generated from sweet potato processing. Int J Food Sci Tech 49:641–649. https://doi.org/10.1111/ijfs.12347
Papanikolaou S, Aggelis G (2011) Lipids of oleaginous yeasts. Part I: biochemistry of single cell oil production. Eur J Lipid Sci Technol 113:1031–1051. https://doi.org/10.1002/ejlt.201100014
Papanikolaou S, Chevalot I, Komaitis M, Aggelis G, Marc I (2001) Kinetic profile of the cellular lipid composition in an oleaginous Yarrowia lipolytica capable of producing a cocoa-butter substitute from industrial fats. Antonie Van Leeuwenhoek 80:215–224. https://doi.org/10.1023/A:1013083211405
Papanikolaou S, Diamantopoulou P, Chatzifragkou A, Philippoussis A, Aggelis G (2010) Suitability of low-cost sugars as substrates for lipid production by the fungus Thamnidium elegans. Energy Fuel 24:4078–4086. https://doi.org/10.1021/ef1004804
Papanikolaou S, Fakas S, Fick M, Chevalot I, Galiotou-Panayotou M, Komaitis M, Marc I, Aggelis G (2008) Biotechnological valorisation of raw glycerol discharged after bio-diesel (fatty acid methyl esters) manufacturing process: production of 1, 3-propanediol, citric acid and single cell oil. Biomass Bioenergy 32:60–71. https://doi.org/10.1016/j.biombioe.2007.06.007
Papanikolaou S, Galiotou-Panayotou M, Fakas S, Komaitis M, Aggelis G (2007) Lipid production by oleaginous Mucorales cultivated on renewable carbon sources. Eur J Lipid Sci Technol 109:1060–1070. https://doi.org/10.1002/ejlt.200700169
Papanikolaou S, Muniglia L, Chevalot I, Aggelis G, Marc I (2003) Accumulation of a cocoa-butter-like lipid by Yarrowia lipolytica cultivated on agro-industrial residues. Curr Microbiol 46:0124–0130. https://doi.org/10.1007/s00284-002-3833-3
Pappu A, Saxena M, Asolekar SR (2007) Solid wastes generation in India and their recycling potential in building materials. Build Environ 42:2311–2320. https://doi.org/10.1016/j.buildenv.2006.04.015
Pauly M, Keegstra K (2008) Cell-wall carbohydrates and their modification as a resource for biofuels. Plant J 54:559–568. https://doi.org/10.1111/j.1365-313X.2008.03463.x
Peng W, Lamei Z, Zhiming Z, Li W, Hui W, Chengling Y, Guohong G (2011) Microbial lipid production by co-fermentation with Mortierella alpina obtained by ion beam implantation. Chem Eng Technol 34:422–428. https://doi.org/10.1002/ceat.201000370
Peng X, Chen H (2008) Single cell oil production in solid-state fermentation by Microsphaeropsis sp. from steam-exploded wheat straw mixed with wheat bran. Bioresour Technol 99:3885–3889. https://doi.org/10.1016/j.biortech.2007.08.015
Qazi GN (2014) opportunities for green chemistry initiatives: molasses based distilleries
Rabelo S, Carrere H, Maciel Filho R, Costa A (2011) Production of bioethanol, methane and heat from sugarcane bagasse in a biorefinery concept. Bioresour Technol 102:7887–7895. https://doi.org/10.1016/j.biortech.2011.05.081
Rakicka M, Lazar Z, Dulermo T, Fickers P, Nicaud JM (2015) Lipid production by the oleaginous yeast Yarrowia lipolytica using industrial by-products under different culture conditions. Biotechnol biofuels 8(1):104. https://doi.org/10.1186/s13068-015-0286-z
Ratledge C (1989) Biotechnology of oils and fats. In: Wilkinson ECRS (ed) “Microbial lipids” vol 2. Academic press, London, pp 567–668
Ratledge C (2001) Microorganisms as sources of polyunsaturated fatty acids. Structured and modified lipids
Ratledge C, Cohen Z (2008) Microbial and algal oils: do they have a future for biodiesel or as commodity oils? Lipid Technol 20:155–160. https://doi.org/10.1002/lite.200800044
Ren H-Y, Liu B-F, Kong F, Zhao L, Ren N (2015) Hydrogen and lipid production from starch wastewater by co-culture of anaerobic sludge and oleaginous microalgae with simultaneous COD, nitrogen and phosphorus removal. Water Res 85:404–412. https://doi.org/10.1016/j.watres.2015.08.057
Ruan Z, Zanotti M, Wang X, Ducey C, Liu Y (2012) Evaluation of lipid accumulation from lignocellulosic sugars by Mortierella isabellina for biodiesel production. Bioresour Technol 110:198–205. https://doi.org/10.1016/j.biortech.2012.01.053
Ryu B-G, Kim J, Kim K, Choi Y-E, Han J-I, Yang J-W (2013a) High-cell-density cultivation of oleaginous yeast Cryptococcus curvatus for biodiesel production using organic waste from the brewery industry. Bioresour Technol 135:357–364. https://doi.org/10.1016/j.biortech.2012.09.054
Ryu B-G, Kim K, Kim J, Han J-I, Yang J-W (2013b) Use of organic waste from the brewery industry for high-density cultivation of the docosahexaenoic acid-rich microalga, Aurantiochytrium sp. KRS101. Bioresour Technol 129:351–359. https://doi.org/10.1016/j.biortech.2012.11.049
Saenge C, Cheirsilp B, Suksaroge TT, Bourtoom T (2011) Efficient concomitant production of lipids and carotenoids by oleaginous red yeast Rhodotorula glutinis cultured in palm oil mill effluent and application of lipids for biodiesel production. Biotechnol Bioprocess Eng 16:23–33. https://doi.org/10.1007/s12257-010-0083-2
Saha BC (2003) Hemicellulose bioconversion. J Ind Microbiol Biotechnol 30:279–291. https://doi.org/10.1007/s10295-003-0049-x
Santamauro F, Whiffin FM, Scott RJ, Chuck CJ (2014) Low-cost lipid production by an oleaginous yeast cultured in non-sterile conditions using model waste resources. Biotechnol Biofuels 7(1):34. https://doi.org/10.1186/1754-6834-7-34
Scarlat N, Motola V, Dallemand J, Monforti-Ferrario F, Mofor L (2015) Evaluation of energy potential of municipal solid waste from African urban areas. Renew Sustainable Energy Rev 50:1269–1286. https://doi.org/10.1016/j.rser.2015.05.067
Shafie S, Masjuki H, Mahlia T (2014) Rice straw supply chain for electricity generation in Malaysia: economical and environmental assessment. Appl Energy 135:299–308. https://doi.org/10.1016/j.apenergy.2014.08.101
Slininger PJ, Dien BS, Kurtzman CP, Moser BR, Bakota EL, Thompson SR, O'Bryan PJ, Cotta MA, Balan V, Jin M, Sousa LC, Dale BE (2016) Comparative lipid production by oleaginous yeasts in hydrolyzates of lignocellulosic biomass and process strategy for high titers. Biotechnol Bioeng 113:1676–1690. https://doi.org/10.1002/bit.25928
Tsigie YA, Wang C-Y, Truong C-T, Ju Y-H (2011) Lipid production from Yarrowia lipolytica Po1g grown in sugarcane bagasse hydrolysate. Bioresour Technol 102:9216–9222. https://doi.org/10.1016/j.biortech.2011.06.047
Vadivelan G, Venkateswaran G (2014) Production and enhancement of omega-3 fatty acid from Mortierella alpina CFR-GV15: its food and therapeutic application. Biomed Res Int 2014:1–9. https://doi.org/10.1155/2014/657414
Wang Y, Gong Z, Yang X, Shen H, Wang Q, Wang J, Zhao ZK (2015) Microbial lipid production from pectin-derived carbohydrates by oleaginous yeasts. Process Biochem 50:1097–1102. https://doi.org/10.1016/j.procbio.2015.04.014
Wei Z, Zeng G, Huang F, Kosa M, Sun Q, Meng X, Huang D, Ragauskas AJ (2015) Microbial lipid production by oleaginous Rhodococci cultured in lignocellulosic autohydrolysates. Appl Microbiol Biotechnol 99:7369–7377. https://doi.org/10.1007/s00253-015-6752-5
Wells T, Wei Z, Ragauskas A (2015) Bioconversion of lignocellulosic pretreatment effluent via oleaginous Rhodococcus opacus DSM 1069. Biomass Bioenergy 72:200–205. https://doi.org/10.1016/j.biombioe.2014.11.004
Xu J, Zhao X, Wang W, Du W, Liu D (2012) Microbial conversion of biodiesel byproduct glycerol to triacylglycerols by oleaginous yeast Rhodosporidium toruloides and the individual effect of some impurities on lipid production. Biochem Eng J 65:30–36. https://doi.org/10.1016/j.bej.2012.04.003
Yang F, Hanna MA, Sun R (2012) Value-added uses for crude glycerol—a byproduct of biodiesel production. Biotechnol Biofuels 5:13. https://doi.org/10.1186/1754-6834-5-13
Yang X, Jin G, Gong Z, Shen H, Bai F, Zhao ZK (2014) Recycling biodiesel-derived glycerol by the oleaginous yeast Rhodosporidium toruloides Y4 through the two-stage lipid production process. Biochem Eng J 91:86–91. https://doi.org/10.1016/j.bej.2014.07.015
Yousuf A, Sannino F, Addorisio V, Pirozzi D (2010) Microbial conversion of olive oil mill wastewaters into lipids suitable for biodiesel production. J Agric Food Chem 58:8630–8635. https://doi.org/10.1021/jf101282t
Yu X-J, Liu J-H, Sun J, Zheng J-Y, Zhang Y-J, Wang Z (2016) Docosahexaenoic acid production from the acidic hydrolysate of Jerusalem artichoke by an efficient sugar-utilizing Aurantiochytrium sp. YLH70. Ind Crop Prod 83:372–378. https://doi.org/10.1016/j.indcrop.2016.01.013
Yu X, Zheng Y, Dorgan KM, Chen S (2011) Oil production by oleaginous yeasts using the hydrolysate from pretreatment of wheat straw with dilute sulfuric acid. Bioresour Technol 102:6134–6140. https://doi.org/10.1016/j.biortech.2011.02.081
Zhang J, Hu B (2012) Solid-state fermentation of Mortierella isabellina for lipid production from soybean hull. Appl Biochem Biotechnol 166:1034–1046. https://doi.org/10.1007/s12010-011-9491-9
Zhang J, Hu B (2014) Microbial lipid production from corn Stover via Mortierella isabellina. Appl Biochem Biotechnol 174:574–586. https://doi.org/10.1007/s12010-014-1117-6
Zhao X, Peng F, Du W, Liu C, Liu D (2012) Effects of some inhibitors on the growth and lipid accumulation of oleaginous yeast Rhodosporidium toruloides and preparation of biodiesel by enzymatic transesterification of the lipid. Bioprocess Biosyst Eng 35:993–1004. https://doi.org/10.1007/s00449-012-0684-6
Zheng Y, Yu X, Zeng J, Chen S (2012) Feasibility of filamentous fungi for biofuel production using hydrolysate from dilute sulfuric acid pretreatment of wheat straw. Biotechnol Biofuels 5:2–10. https://doi.org/10.1186/1754-6834-5-50
Zhu L, Zong M, Wu H (2008) Efficient lipid production with Trichosporon fermentans and its use for biodiesel preparation. Bioresour Technol 99:7881–7885. https://doi.org/10.1016/j.biortech.2008.02.033
Zikou E, Chatzifragkou A, Koutinas A, Papanikolaou S (2013) Evaluating glucose and xylose as cosubstrates for lipid accumulation and γ-linolenic acid biosynthesis of Thamnidium elegans. J Appl Microbiol 114:1020–1032. https://doi.org/10.1111/jam.12116
Acknowledgements
The authors heartily acknowledge Professor Colin Ratledge, one of the pioneers in this field, for his constructive advices and comments towards improving the technicalities of the manuscript.
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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
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Diwan, B., Parkhey, P. & Gupta, P. From agro-industrial wastes to single cell oils: a step towards prospective biorefinery. Folia Microbiol 63, 547–568 (2018). https://doi.org/10.1007/s12223-018-0602-7
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DOI: https://doi.org/10.1007/s12223-018-0602-7