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Strategies of complementary and integrative therapies in cancer-related pain—attaining exhaustive cancer pain management

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Abstract

Purpose

Complementary integrative therapies (CITs) correspond to growing demand in patients with cancer-related pain. This demand needs to be considered alongside pharmaceutical and/or interventional therapies. CITs can be used to cover certain specific pain-related characteristics. The objective of this review is to present the options for CITs that could be used within dynamic, multidisciplinary, and personalized management, leading to an integrative oncology approach.

Methods

Critical reflection based on literature analysis and clinical practice.

Results

Most CITs only showed trends in efficacy as cancer pain was mainly a secondary endpoint, or populations were restricted. Physical therapy has demonstrated efficacy in motion and pain, in some specific cancers (head and neck or breast cancers) or in treatments sequelae (lymphedema). In cancer survivors, higher levels of physical activity decrease pain intensity. Due to the multimorphism of cancer pain, certain mind-body therapies acting on anxiety, stress, depression, or mood disturbances (such as massage, acupuncture, healing touch, hypnosis, and music therapy) are efficient on cancer pain. Other mind-body therapies have shown trends in reducing the severity of cancer pain and improving other parameters, and they include education (with coping skills training), yoga, tai chi/qigong, guided imagery, virtual reality, and cognitive-behavioral therapy alone or combined. The outcome sustainability of most CITs is still questioned.

Conclusions

High-quality clinical trials should be conducted with CITs, as their efficacy on pain is mainly based on efficacy trends in pain severity, professional judgment, and patient preferences. Finally, the implementation of CITs requires an interdisciplinary team approach to offer optimal, personalized, cancer pain management.

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References

  1. Merskey H, Bogduk N (1994) Classification of chronic pain. Descriptions of chronic pain syndromes and definitions of pain terms. Prepared by the task force on taxonomy of the International Association for the Study of Pain, 2nd ed. IASP Press, Seattle

  2. Syrjala KL, Jensen MP, Mendoza ME, Yi JC, Fisher HM, Keefe FJ (2014) Psychological and behavioral approaches to cancer pain management. J Clin Oncol 32:1703–1711. https://doi.org/10.1200/JCO.2013.54.4825

    Article  PubMed  PubMed Central  Google Scholar 

  3. Cassell E (2004) The nature of suffering and the goals of medicine, 2nd edn. Oxford University Press, Oxford

    Book  Google Scholar 

  4. Harrington CB, Hansen JA, Moskowitz M, Todd BL, Feuerstein M (2010) It’s not over when it’s over: long-term symptoms in cancer survivors—a systematic review. Int J Psychiatry Med 40:163–181. https://doi.org/10.2190/PM.40.2.c

    Article  PubMed  Google Scholar 

  5. Institut national du Cancer (INCA) (2012) Synthèse de l’enquête nationale 2010 sur la prise en charge de la douleur chez des patients adultes atteints de cancer. www.e-cancer.fr/content/download/63502/571325/file/ENQDOUL12.pdf. Accessed 17 July 2018

  6. Breivik H, Cherny N, Collett B, de Conno F, Filbet M, Foubert AJ, Cohen R, Dow L (2009) Cancer-related pain: a pan-European survey of prevalence, treatment, and patient attitudes. Ann Oncol 20:1420–1433. https://doi.org/10.1093/annonc/mdp001

    Article  CAS  PubMed  Google Scholar 

  7. Valeberg BT, Rustøen T, Bjordal K et al (2008) Self-reported prevalence, etiology, and characteristics of pain in oncology outpatients. Eur J Pain 12:582–590. https://doi.org/10.1016/j.ejpain.2007.09.004

    Article  PubMed  Google Scholar 

  8. Greco MT, Roberto A, Corli O, Deandrea S, Bandieri E, Cavuto S, Apolone G (2014) Quality of cancer pain management: an update of a systematic review of undertreatment of patients with cancer. J Clin Oncol 32:4149–4154. https://doi.org/10.1200/JCO.2014.56.0383

    Article  PubMed  Google Scholar 

  9. Breuer B, Chang VT, Von Roenn JH et al (2015) How well do medical oncologists manage chronic cancer pain? A national survey. Oncologist 20:202–209. https://doi.org/10.1634/theoncologist.2014-0276

    Article  PubMed  PubMed Central  Google Scholar 

  10. Mayor S (2000) Survey of patients shows that cancer pain still undertreated. BMJ 321:1309–1309. https://doi.org/10.1136/bmj.321.7272.1309/b

    Article  PubMed Central  Google Scholar 

  11. MacDonald N, Ayoub J, Farley J, Foucault C, Lesage P, Mayo N (2002) A Quebec survey of issues in cancer pain management. J Pain Symptom Manag 23:39–47. https://doi.org/10.1016/S0885-3924(01)00374-8

    Article  Google Scholar 

  12. Hsieh RK (2005) Pain control in Taiwanese patients with cancer: a multicenter, patient-oriented survey. J Formos Med Assoc 104:913–919

    PubMed  Google Scholar 

  13. Kasasbeh MAM, McCabe C, Payne S (2017) Cancer-related pain management: a review of knowledge and attitudes of healthcare professionals. Eur J Cancer Care (Engl) 26:e12625. https://doi.org/10.1111/ecc.12625

    Article  Google Scholar 

  14. Chow R, Saunders K, Burke H, Belanger A, Chow E (2017) Needs assessment of primary care physicians in the management of chronic pain in cancer survivors. Support Care Cancer 25:3505–3514. https://doi.org/10.1007/s00520-017-3774-9

    Article  PubMed  Google Scholar 

  15. Raphael J, Hester J, Ahmedzai S, Barrie J, Farqhuar-Smith P, Williams J, Urch C, Bennett MI, Robb K, Simpson B, Pittler M, Wider B, Ewer-Smith C, DeCourcy J, Young A, Liossi C, McCullough R, Rajapakse D, Johnson M, Duarte R, Sparkes E (2010) Cancer pain: part 2: physical, interventional and complimentary therapies; management in the community; acute, treatment-related and complex cancer pain: a perspective from the British pain society endorsed by the UK Association of Palliative Medicine and. Pain Med 11:872–896. https://doi.org/10.1111/j.1526-4637.2010.00841.x

    Article  PubMed  Google Scholar 

  16. Raffa RB, Pergolizzi JV (2014) A modern analgesics pain “pyramid”. J Clin Pharm Ther 39:4–6. https://doi.org/10.1111/jcpt.12110

    Article  CAS  PubMed  Google Scholar 

  17. Chwistek M (2017) Recent advances in understanding and managing cancer pain. F1000Research 6:945. https://doi.org/10.12688/f1000research.10817.1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Candido KD, Kusper TM, Knezevic NN (2017) New cancer pain treatment options. Curr Pain Headache Rep 21(12):12. https://doi.org/10.1007/s11916-017-0613-0

    Article  PubMed  Google Scholar 

  19. Bennett MI, Eisenberg E, Ahmedzai SH et al (2018) Standards for the management of cancer-related pain across Europe. A position paper from the EFIC task force on cancer pain. Eur J Pain. https://doi.org/10.1002/ejp.1346

  20. Goldstein MS, Brown ER, Ballard-Barbash R et al (2005) The use of complementary and alternative medicine among California adults with and without cancer. Evid Based Complement Alternat Med 2:557–565. https://doi.org/10.1093/ecam/neh138

    Article  PubMed  PubMed Central  Google Scholar 

  21. Ernst E, Pittler MH, Wider B, Boddy K (2007) Complementary therapies for pain management: an evidence-based approach. Complement Ther pain Manag an evidence-based approach

  22. Ernst E, Pittler MH, Wider B, Boddy K (2008) Oxford handbook of complementary medicine. Oxford University Press, Oxford

    Book  Google Scholar 

  23. Davis EL, Oh B, Butow PN, Mullan BA, Clarke S (2012) Cancer patient disclosure and patient-doctor communication of complementary and alternative medicine use: a systematic review. Oncologist 17:1475–1481. https://doi.org/10.1634/theoncologist.2012-0223

    Article  PubMed  PubMed Central  Google Scholar 

  24. Ernst E (2010) The public’s enthusiasm for complementary and alternative medicine amounts to a critique of mainstream medicine. Int J Clin Pract 64:1472–1474. https://doi.org/10.1111/j.1742-1241.2010.02425.x

    Article  CAS  PubMed  Google Scholar 

  25. Stein KD, Syrjala KL, Andrykowski MA (2008) Physical and psychological long-term and late effects of cancer. Cancer 112:2577–2592. https://doi.org/10.1002/cncr.23448

    Article  PubMed  Google Scholar 

  26. National Center for Complementary and Integrative Health (NCCIH) (2016) Complementary, alternative, or integrative health: what’s in a name? https://nccih.nih.gov/health/integrative-health#integrative. Accessed 17 July 2018

  27. Van Hecke O, Torrance N, Smith BH (2013) Chronic pain epidemiology—where do lifestyle factors fit in? Br J Pain 7:209–217. https://doi.org/10.1177/2049463713493264

    Article  PubMed  PubMed Central  Google Scholar 

  28. McNeely ML, Parliament M, Courneya KS et al (2004) A pilot study of a randomized controlled trial to evaluate the effects of progressive resistance exercise training on shoulder dysfunction caused by spinal accessory neurapraxia/neurectomy in head and neck cancer survivors. Head Neck 26:518–530. https://doi.org/10.1002/hed.20010

    Article  PubMed  Google Scholar 

  29. McNeely ML, Parliament MB, Seikaly H et al (2008) Effect of exercise on upper extremity pain and dysfunction in head and neck cancer survivors. Cancer 113:214–222. https://doi.org/10.1002/cncr.23536

    Article  PubMed  Google Scholar 

  30. Rogers LQ, Courneya KS, Robbins KT, Malone J, Seiz A, Koch L, Rao K (2008) Physical activity correlates and barriers in head and neck cancer patients. Support Care Cancer 16:19–27. https://doi.org/10.1007/s00520-007-0293-0

    Article  PubMed  Google Scholar 

  31. Rock CL, Doyle C, Demark-Wahnefried W et al (2012) Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin 62:242–274. https://doi.org/10.3322/caac.21142

    Article  Google Scholar 

  32. Nelson ME, Rejeski WJ, Blair SN et al (2007) Physical activity and public health in older adults. Med Sci Sports Exerc 39:1435–1445. https://doi.org/10.1249/mss.0b013e3180616aa2

    Article  PubMed  Google Scholar 

  33. Brosse AL, Sheets ES, Lett HS, Blumenthal JA (2002) Exercise and the treatment of clinical depression in adults. Sports Med 32:741–760. https://doi.org/10.2165/00007256-200232120-00001

    Article  PubMed  Google Scholar 

  34. Park C, Malavasi L, Martin P et al (2008) Integrating qi-gong/tai-chi experiences into traditional Western physical activity programs in a long-term care retirement community: 615. Med Sci Sports Exerc 40:S24. https://doi.org/10.1249/01.mss.0000321549.50666.24

    Article  Google Scholar 

  35. Wolin KY, Schwartz AL, Matthews CE et al (2012) Implementing the exercise guidelines for cancer survivors. J Support Oncol 10:171–177. https://doi.org/10.1016/j.suponc.2012.02.001

    Article  PubMed  PubMed Central  Google Scholar 

  36. Bouillet T, Bigard X, Brami C et al (2015) Role of physical activity and sport in oncology. Crit Rev Oncol Hematol 94:74–86. https://doi.org/10.1016/j.critrevonc.2014.12.012

    Article  CAS  PubMed  Google Scholar 

  37. Mancuso P (2016) The role of adipokines in chronic inflammation. ImmunoTargets Ther 5:47. https://doi.org/10.2147/ITT.S73223

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. National Cancer Policy Board (2005) From cancer patient to cancer survivor: lost in transition. Hewitt M, Greenfield S, Stovall, E (eds). The National Academies Press, Washington, DC. http://georgiacore.org/articleImages/articlePDF_396.pdf. Accessed 17 Ju

  39. Santa Mina D, Au D, Brunet J et al (2017) Effects of the community-based wellspring cancer exercise program on functional and psychosocial outcomes in cancer survivors. Curr Oncol 24:284–294. https://doi.org/10.3747/co.23.3585

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Forsythe LP, Alfano CM, George SM, McTiernan A, Baumgartner KB, Bernstein L, Ballard-Barbash R (2013) Pain in long-term breast cancer survivors: the role of body mass index, physical activity, and sedentary behavior. Breast Cancer Res Treat 137:617–630. https://doi.org/10.1007/s10549-012-2335-7

    Article  PubMed  Google Scholar 

  41. Rajotte EJ, Yi JC, Baker KS et al (2012) Community-based exercise program effectiveness and safety for cancer survivors. J Cancer Surviv 6:219–228. https://doi.org/10.1007/s11764-011-0213-7

    Article  PubMed  PubMed Central  Google Scholar 

  42. Knobf MT, Thompson AS, Fennie K, Erdos D (2014) The effect of a community-based exercise intervention on symptoms and quality of life. Cancer Nurs 37:E43–E50. https://doi.org/10.1097/NCC.0b013e318288d40e

    Article  PubMed  PubMed Central  Google Scholar 

  43. Basen-Engquist K, Taylor CLC, Rosenblum C, Smith MA, Shinn EH, Greisinger A, Gregg X, Massey P, Valero V, Rivera E (2006) Randomized pilot test of a lifestyle physical activity intervention for breast cancer survivors. Patient Educ Couns 64:225–234. https://doi.org/10.1016/j.pec.2006.02.006

    Article  PubMed  Google Scholar 

  44. Rogers LQ, Courneya KS, Robbins KT et al (2006) Physical activity and quality of life in head and neck cancer survivors. Support Care Cancer 14:1012–1019. https://doi.org/10.1007/s00520-006-0044-7

    Article  PubMed  Google Scholar 

  45. Greenlee H, DuPont-Reyes MJ, Balneaves LG et al (2017) Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA Cancer J Clin 67:194–232. https://doi.org/10.3322/caac.21397

    Article  PubMed  PubMed Central  Google Scholar 

  46. National Center for Complementary and Integrative Health (2017) Massage therapy for health purposes. https://nccih.nih.gov/health/massage/massageintroduction.htm. Accessed 17 July 2018

  47. Jane S-W, Chen S-L, Wilkie DJ et al (2011) Effects of massage on pain, mood status, relaxation, and sleep in Taiwanese patients with metastatic bone pain: a randomized clinical trial. Pain 152:2432–2442. https://doi.org/10.1016/j.pain.2011.06.021

    Article  PubMed  Google Scholar 

  48. Post-White J, Kinney ME, Savik K, Gau JB, Wilcox C, Lerner I (2003) Therapeutic massage and healing touch improve symptoms in cancer. Integr Cancer Ther 2:332–344. https://doi.org/10.1177/1534735403259064

    Article  PubMed  Google Scholar 

  49. Corbin L (2005) Safety and efficacy of massage therapy for patients with cancer. Cancer Control 12:158–164. https://doi.org/10.1177/107327480501200303

    Article  PubMed  Google Scholar 

  50. Fuentes-Márquez P, Cabrera-Martos I, Valenza MC (2018) Physiotherapy interventions for patients with chronic pelvic pain: a systematic review of the literature. Physiother Theory Pract:1–8. https://doi.org/10.1080/09593985.2018.1472687

  51. Crawford C, Boyd C, Paat CF, Price A, Xenakis L, Yang EM, Zhang W, the Evidence for Massage Therapy (EMT) Working Group (2016) The impact of massage therapy on function in pain populations—a systematic review and meta-analysis of randomized controlled trials: part I, patients experiencing pain in the general population. Pain Med 17:1353–1375. https://doi.org/10.1093/pm/pnw099

    Article  PubMed  PubMed Central  Google Scholar 

  52. Guo Y, Qiu P, Liu T (2014) Tai Ji Quan: an overview of its history, health benefits, and cultural value. J Sport Health Sci 3:3–8. https://doi.org/10.1016/J.JSHS.2013.10.004

    Article  Google Scholar 

  53. National Cancer Institute. Office of Cancer Complementary and Alternative Medicine (2013) Tai chi exercise studied to improve quality of life for senior cancer survivors. https://cam.cancer.gov/cam_at_nci/annual_report/2010/tai_chi_survivors.htm. Accessed

  54. National Center for Complementary and Integrative Health (2017) Mind and body research—information for researchers. https://nccih.nih.gov/grants/mindbody. Accessed 17 July 2018

  55. National Cancer Institute. Office of Cancer Complementary and Alternative Medicine (2013) Yoga and Cancer https://cam.cancer.gov/health_information/highlights/yoga_cancer_highlight.htm. Accessed 17 July 2018

  56. National Cancer Institute. Office of Cancer Complementary and Alternative Medicine (2016) Research priorities https://cam.cancer.gov/about_us/about_occam.htm#priorities. Accessed 17 July 2018

  57. Buffart LM, van Uffelen JG, Riphagen II et al (2012) Physical and psychosocial benefits of yoga in cancer patients and survivors, a systematic review and meta-analysis of randomized controlled trials. BMC Cancer 12:559. https://doi.org/10.1186/1471-2407-12-559

    Article  PubMed  PubMed Central  Google Scholar 

  58. Carson JW, Carson KM, Porter LS, Keefe FJ, Seewaldt VL (2009) Yoga of awareness program for menopausal symptoms in breast cancer survivors: results from a randomized trial. Support Care Cancer 17:1301–1309. https://doi.org/10.1007/s00520-009-0587-5

    Article  PubMed  Google Scholar 

  59. Lou GM, Desai K, Greene L et al (2012) Impact of yoga on functional outcomes in breast cancer survivors with aromatase inhibitor-associated arthralgias. Integr Cancer Ther 11:313–320. https://doi.org/10.1177/1534735411413270

    Article  Google Scholar 

  60. Yan J-H, Gu W-J, Sun J et al (2013) Efficacy of tai chi on pain, stiffness and function in patients with osteoarthritis: a meta-analysis. PLoS One 8:e61672. https://doi.org/10.1371/journal.pone.0061672

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Wayne PM, Lee MS, Novakowski J, Osypiuk K, Ligibel J, Carlson LE, Song R (2018) Tai chi and Qigong for cancer-related symptoms and quality of life: a systematic review and meta-analysis. J Cancer Surviv 12:256–267. https://doi.org/10.1007/s11764-017-0665-5

    Article  PubMed  Google Scholar 

  62. National Center for Complementary and Integrative Health (2016) Tai chi and qi gong: in depth. https://nccih.nih.gov/health/taichi/introduction.htm. Accessed 17 July 2018

  63. Campo RA, O’Connor K, Light KC, Nakamura Y, Lipschitz DL, LaStayo PC, Pappas L, Boucher K, Irwin MR, Agarwal N, Kinney AY (2013) Feasibility and acceptability of a tai chi chih randomized controlled trial in senior female cancer survivors. Integr Cancer Ther 12:464–474. https://doi.org/10.1177/1534735413485418

    Article  PubMed  Google Scholar 

  64. Hu C, Zhang H, Wu W, Yu W, Li Y, Bai J, Luo B, Li S (2016) Acupuncture for pain management in cancer: a systematic review and meta-analysis. Evid Based Complement Alternat Med 2016:1–13. https://doi.org/10.1155/2016/1720239

    Article  Google Scholar 

  65. Bardia A, Barton DL, Prokop LJ et al (2006) Efficacy of complementary and alternative medicine therapies in relieving cancer pain: a systematic review. J Clin Oncol 24:5457–5464. https://doi.org/10.1200/JCO.2006.08.3725

    Article  PubMed  Google Scholar 

  66. Chiu HY, Hsieh YJ, Tsai PS (2017) Systematic review and meta-analysis of acupuncture to reduce cancer-related pain. Eur J Cancer Care (Engl) 26:e12457. https://doi.org/10.1111/ecc.12457

    Article  Google Scholar 

  67. Bao T, Cai L, Giles JT, Gould J, Tarpinian K, Betts K, Medeiros M, Jeter S, Tait N, Chumsri S, Armstrong DK, Tan M, Folkerd E, Dowsett M, Singh H, Tkaczuk K, Stearns V (2013) A dual-center randomized controlled double blind trial assessing the effect of acupuncture in reducing musculoskeletal symptoms in breast cancer patients taking aromatase inhibitors. Breast Cancer Res Treat 138:167–174. https://doi.org/10.1007/s10549-013-2427-z

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Crew KD, Capodice JL, Greenlee H, Brafman L, Fuentes D, Awad D, Yann Tsai W, Hershman DL (2010) Randomized, blinded, sham-controlled trial of acupuncture for the management of aromatase inhibitor-associated joint symptoms in women with early-stage breast cancer. J Clin Oncol 28:1154–1160. https://doi.org/10.1200/JCO.2009.23.4708

    Article  CAS  PubMed  Google Scholar 

  69. Oh B, Kimble B, Costa DSJ, Davis E, McLean A, Orme K, Beith J (2013) Acupuncture for treatment of arthralgia secondary to aromatase inhibitor therapy in women with early breast cancer: pilot study. Acupunct Med 31:264–271. https://doi.org/10.1136/acupmed-2012-010309

    Article  CAS  PubMed  Google Scholar 

  70. Mao JJ, Xie SX, Farrar JT, Stricker CT, Bowman MA, Bruner D, DeMichele A (2014) A randomised trial of electro-acupuncture for arthralgia related to aromatase inhibitor use. Eur J Cancer 50:267–276. https://doi.org/10.1016/j.ejca.2013.09.022

    Article  CAS  PubMed  Google Scholar 

  71. Paley CA, Johnson MI, Tashani OA, Bagnall A-M (2015) Acupuncture for cancer pain in adults. Cochrane Database Syst Rev CD007753. https://doi.org/10.1002/14651858.CD007753.pub3

  72. Robb KA, Newham DJ, Williams JE (2007) Transcutaneous electrical nerve stimulation vs. transcutaneous spinal electroanalgesia for chronic pain associated with breast cancer treatments. J Pain Symptom Manag 33:410–419. https://doi.org/10.1016/j.jpainsymman.2006.09.020

    Article  Google Scholar 

  73. Hurlow A, Bennett MI, Robb KA, et al (2012) Transcutaneous electric nerve stimulation (TENS) for cancer pain in adults. Cochrane Database Syst Rev CD006276. https://doi.org/10.1002/14651858.CD006276.pub3

  74. Moon JY, Kurihara C, Beckles JP, Williams KE, Jamison DE, Cohen SP (2015) Predictive factors associated with success and failure for Calmare (scrambler) therapy. Clin J Pain 31:750–756. https://doi.org/10.1097/AJP.0000000000000155

    Article  PubMed  Google Scholar 

  75. Lee SC, Park KS, Moon JY, Kim EJ, Kim YC, Seo H, Sung JK, Lee DJ (2016) An exploratory study on the effectiveness of “Calmare therapy” in patients with cancer-related neuropathic pain: a pilot study. Eur J Oncol Nurs 21:1–7. https://doi.org/10.1016/j.ejon.2015.12.001

    Article  PubMed  Google Scholar 

  76. Notaro P, Dell’Agnola CA, Dell’Agnola AJ, Amatu A, Bencardino KB, Siena S (2016) Pilot evaluation of scrambler therapy for pain induced by bone and visceral metastases and refractory to standard therapies. Support Care Cancer 24:1649–1654. https://doi.org/10.1007/s00520-015-2952-x

    Article  PubMed  Google Scholar 

  77. Reyes-Gibby CC, Anderson KO, Morrow PK et al (2012) Depressive symptoms and health-related quality of life in breast cancer survivors. J Women’s Health 21:311–318. https://doi.org/10.1089/jwh.2011.2852

    Article  Google Scholar 

  78. Strada EA, Portenoy RK (2017) Psychological, rehabilitative, and integrative therapies for cancer pain. Uptodate. https://www.uptodate.com/contents/psychological-rehabilitative-and-integrative-therapies-for-cancer-pain#H44713544. Accessed 17 July 2018

  79. Mustafa M, Carson-Stevens A, Gillespie D, Edwards AG (2013) Psychological interventions for women with metastatic breast cancer. Cochrane Database Syst Rev CD004253. https://doi.org/10.1002/14651858.CD004253.pub4

  80. Lee R (1999) Guided imagery as supportive therapy in cancer treatment. Altern Med 2:61–64

    Google Scholar 

  81. Roffe L, Schmidt K, Ernst E (2005) A systematic review of guided imagery as an adjuvant cancer therapy. Psychooncology 14:607–617. https://doi.org/10.1002/pon.889

    Article  PubMed  Google Scholar 

  82. Sheinfeld Gorin S, Krebs P, Badr H et al (2012) Meta-analysis of psychosocial interventions to reduce pain in patients with cancer. J Clin Oncol 30:539–547. https://doi.org/10.1200/JCO.2011.37.0437

    Article  PubMed  PubMed Central  Google Scholar 

  83. Johannsen M, Farver I, Beck N, Zachariae R (2013) The efficacy of psychosocial intervention for pain in breast cancer patients and survivors: a systematic review and meta-analysis. Breast Cancer Res Treat 138:675–690. https://doi.org/10.1007/s10549-013-2503-4

    Article  CAS  PubMed  Google Scholar 

  84. Wint SS, Eshelman D, Steele J, Guzzetta CE (2002) Effects of distraction using virtual reality glasses during lumbar punctures in adolescents with cancer. Oncol Nurs Forum 29:E8–E15. https://doi.org/10.1188/02.ONF.E8-E15

    Article  Google Scholar 

  85. Schneider SM, Workman ML Virtual reality as a distraction intervention for older children receiving chemotherapy. Pediatr Nurs 26:593–597

  86. Gershon J, Zimand E, Pickering M, Rothbaum BO, Hodges L (2004) A pilot and feasibility study of virtual reality as a distraction for children with cancer. J Am Acad Child Adolesc Psychiatry 43:1243–1249. https://doi.org/10.1097/01.chi.0000135621.23145.05

    Article  PubMed  Google Scholar 

  87. Chirico A, Lucidi F, De Laurentiis M et al (2016) Virtual reality in health system: beyond entertainment. A mini-review on the efficacy of VR during cancer treatment. J Cell Physiol 231:275–287. https://doi.org/10.1002/jcp.25117

    Article  CAS  PubMed  Google Scholar 

  88. Indovina P, Barone D, Gallo L et al (2018) Virtual reality as a distraction intervention to relieve pain and distress during medical procedures. Clin J Pain 34:1. https://doi.org/10.1097/AJP.0000000000000599

    Article  Google Scholar 

  89. House G, Burdea G, Grampurohit N, Polistico K, Roll D, Damiani F, Hundal J, Demesmin D (2016) A feasibility study to determine the benefits of upper extremity virtual rehabilitation therapy for coping with chronic pain post-cancer surgery. Br J Pain 10:186–197. https://doi.org/10.1177/2049463716664370

    Article  PubMed  PubMed Central  Google Scholar 

  90. Tashjian VC, Mosadeghi S, Howard AR, Lopez M, Dupuy T, Reid M, Martinez B, Ahmed S, Dailey F, Robbins K, Rosen B, Fuller G, Danovitch I, IsHak W, Spiegel B (2017) Virtual reality for management of pain in hospitalized patients: results of a controlled trial. JMIR Ment Health 4:e9. https://doi.org/10.2196/mental.7387

    Article  PubMed  PubMed Central  Google Scholar 

  91. Li A, Montaño Z, Chen VJ, Gold JI (2011) Virtual reality and pain management: current trends and future directions. Pain Manag 1:147–157. https://doi.org/10.2217/pmt.10.15

    Article  PubMed  Google Scholar 

  92. Kwekkeboom KL, Cherwin CH, Lee JW, Wanta B (2010) Mind-body treatments for the pain-fatigue-sleep disturbance symptom cluster in persons with cancer. J Pain Symptom Manag 39:126–138. https://doi.org/10.1016/j.jpainsymman.2009.05.022

    Article  Google Scholar 

  93. Mendoza ME, Capafons A, Gralow JR et al (2017) Randomized controlled trial of the Valencia model of waking hypnosis plus CBT for pain, fatigue, and sleep management in patients with cancer and cancer survivors. Psychooncology 26:1832–1838. https://doi.org/10.1002/pon.4232

    Article  CAS  PubMed  Google Scholar 

  94. Institut National du Cancer (2016) Axes opportuns d’évolution du panier de soins oncologiques de support. http://www.e-cancer.fr/Expertises-et-publications/Catalogue-des-publications/Axes-opportuns-d-evolution-du-panier-des-soins-oncologiques-de-support-R

    Google Scholar 

  95. Butler LD, Koopman C, Neri E, Giese-Davis J, Palesh O, Thorne-Yocam KA, Dimiceli S, Chen XH, Fobair P, Kraemer HC, Spiegel D (2009) Effects of supportive-expressive group therapy on pain in women with metastatic breast cancer. Health Psychol 28:579–587. https://doi.org/10.1037/a0016124

    Article  PubMed  Google Scholar 

  96. Goodwin PJ, Leszcz M, Ennis M et al (2001) The effect of group psychosocial support on survival in metastatic breast Cancer. N Engl J Med 345:1719–1726. https://doi.org/10.1056/NEJMoa011871

    Article  CAS  PubMed  Google Scholar 

  97. Spiegel D, Bloom JR (1983) Group therapy and hypnosis reduce metastatic breast carcinoma pain. Psychosom Med 45:333–339

    Article  CAS  PubMed  Google Scholar 

  98. Binns-Turner PG, Wilson LL, Pryor ER, Boyd GL, Prickett CA (2011) Perioperative music and its effects on anxiety, hemodynamics, and pain in women undergoing mastectomy. AANA J 79:S21–S27

    PubMed  Google Scholar 

  99. Li X-M, Zhou K-N, Yan H et al (2012) Effects of music therapy on anxiety of patients with breast cancer after radical mastectomy: a randomized clinical trial. J Adv Nurs 68:1145–1155. https://doi.org/10.1111/j.1365-2648.2011.05824.x

    Article  PubMed  Google Scholar 

  100. Wang Y, Tang H, Guo Q et al (2015) Effects of intravenous patient-controlled sufentanil analgesia and music therapy on pain and hemodynamics after surgery for lung cancer: a randomized parallel study. J Altern Complement Med 21:667–672. https://doi.org/10.1089/acm.2014.0310

    Article  PubMed  Google Scholar 

  101. Bradt J, Dileo C, Magill L, Teague A (2016) Music interventions for improving psychological and physical outcomes in cancer patients. Cochrane Database Syst Rev CD006911. https://doi.org/10.1002/14651858.CD006911.pub3

  102. Lee JH (2016) The effects of music on pain: a meta-analysis. J Music Ther 53:430–477. https://doi.org/10.1093/jmt/thw012

    Article  PubMed  Google Scholar 

  103. Gunnarsdottir S, Sigurdardottir V, Kloke M et al (2017) A multicenter study of attitudinal barriers to cancer pain management. Support Care Cancer 25:3595–3602. https://doi.org/10.1007/s00520-017-3791-8

    Article  PubMed  Google Scholar 

  104. Valeberg BT, Miaskowski C, Paul SM, Rustøen T (2016) Comparison of oncology patients’ and their family caregivers’ attitudes and concerns toward pain and pain management. Cancer Nurs 39:328–334. https://doi.org/10.1097/NCC.0000000000000319

    Article  PubMed  Google Scholar 

  105. Peacock S, Patel S (2008) Cultural influences on pain. Rev Pain 1:6–9. https://doi.org/10.1177/204946370800100203

    Article  PubMed  PubMed Central  Google Scholar 

  106. Bosch F, Baños JE (2002) Religious beliefs of patients and caregivers as a barrier to the pharmacologic control of cancer pain*. Clin Pharmacol Ther 72:107–111. https://doi.org/10.1067/mcp.2002.126180

    Article  PubMed  Google Scholar 

  107. Green CR, Anderson KO, Baker TA et al (2003) The unequal burden of pain: confronting racial and ethnic disparities in pain. Pain Med 4:277–294

    Article  PubMed  Google Scholar 

  108. Chen CH, Tang ST, Chen CH (2012) Meta-analysis of cultural differences in Western and Asian patient-perceived barriers to managing cancer pain. Palliat Med 26:206–221. https://doi.org/10.1177/0269216311402711

    Article  PubMed  Google Scholar 

  109. Edwards RR, Moric M, Husfeldt B et al (2005) Ethnic similarities and differences in the chronic pain experience: a comparison of African American, Hispanic, and White patients. Pain Med 6:88–98. https://doi.org/10.1111/j.1526-4637.2005.05007.x

    Article  PubMed  Google Scholar 

  110. Grant JA, Courtemanche J, Rainville P (2011) A non-elaborative mental stance and decoupling of executive and pain-related cortices predicts low pain sensitivity in zen meditators. Pain 152:150–156. https://doi.org/10.1016/j.pain.2010.10.006

    Article  PubMed  Google Scholar 

  111. Baer RA (2006) Mindfulness training as a clinical intervention: a conceptual and empirical review. Clin Psychol Sci Pract 10:125–143. https://doi.org/10.1093/clipsy.bpg015

    Article  Google Scholar 

  112. Grossman P, Niemann L, Schmidt S, Walach H (2004) Mindfulness-based stress reduction and health benefits. J Psychosom Res 57:35–43. https://doi.org/10.1016/S0022-3999(03)00573-7

    Article  PubMed  Google Scholar 

  113. Turner JA, Anderson ML, Balderson BH, Cook AJ, Sherman KJ, Cherkin DC (2016) Mindfulness-based stress reduction and cognitive behavioral therapy for chronic low back pain. Pain 157:2434–2444. https://doi.org/10.1097/j.pain.0000000000000635

    Article  PubMed  PubMed Central  Google Scholar 

  114. Rosenzweig S, Greeson JM, Reibel DK, Green JS, Jasser SA, Beasley D (2010) Mindfulness-based stress reduction for chronic pain conditions: variation in treatment outcomes and role of home meditation practice. J Psychosom Res 68:29–36. https://doi.org/10.1016/j.jpsychores.2009.03.010

    Article  PubMed  Google Scholar 

  115. Hilton L, Hempel S, Ewing BA, Apaydin E, Xenakis L, Newberry S, Colaiaco B, Maher AR, Shanman RM, Sorbero ME, Maglione MA (2017) Mindfulness meditation for chronic pain: systematic review and meta-analysis. Ann Behav Med 51:199–213. https://doi.org/10.1007/s12160-016-9844-2

    Article  PubMed  Google Scholar 

  116. Ball EF, Nur Shafina Muhammad Sharizan E, Franklin G, Rogozińska E (2017) Does mindfulness meditation improve chronic pain? A systematic review. Curr Opin Obstet Gynecol 29:1. https://doi.org/10.1097/GCO.0000000000000417

    Article  Google Scholar 

  117. Satija A, Bhatnagar S (2017) Complementary therapies for symptom management in cancer patients. Indian J Palliat Care 23:468–479. https://doi.org/10.4103/IJPC.IJPC_100_17

    Article  PubMed  PubMed Central  Google Scholar 

  118. Lee CE, Kim S, Kim S et al (2017) Effects of a mindfulness-based stress reduction program on the physical and psychological status and quality of life in patients with metastatic breast cancer. Holist Nurs Pract 31:260–269. https://doi.org/10.1097/HNP.0000000000000220

    Article  PubMed  Google Scholar 

  119. Luebbert K, Dahme B, Hasenbring M (2001) The effectiveness of relaxation training in reducing treatment-related symptoms and improving emotional adjustment in acute non-surgical cancer treatment: a meta-analytical review. Psychooncology 10:490–502

    Article  CAS  PubMed  Google Scholar 

  120. Roth AD, Pilling S (2008) Using an evidence-based methodology to identify the competences required to deliver effective cognitive and behavioural therapy for depression and anxiety disorders. Behav Cogn Psychother 36:129–147. https://doi.org/10.1017/S1352465808004141

    Article  Google Scholar 

  121. McCracken LM, Vowles KE (2014) Acceptance and commitment therapy and mindfulness for chronic pain: model, process, and progress. Am Psychol 69:178–187. https://doi.org/10.1037/a0035623

    Article  PubMed  Google Scholar 

  122. The British Pain Society (ed) (2017) Recommended guidelines for pain management programmes for adults. The British Pain Society (ed), London

    Google Scholar 

  123. Hunot V, Moore TH, Caldwell D, et al (2010) Mindfulness-based “third wave” cognitive and behavioural therapies versus other psychological therapies for depression. In: Churchill R (ed) Cochrane database of systematic reviews. John Wiley & Sons, Ltd, Chichester

  124. Carver CS, Smith RG, Antoni MH, Petronis VM, Weiss S, Derhagopian RP (2005) Optimistic personality and psychosocial well-being during treatment predict psychosocial well-being among long-term survivors of breast cancer. Health Psychol 24:508–516. https://doi.org/10.1037/0278-6133.24.5.508

    Article  PubMed  Google Scholar 

  125. Phillips KM, Antoni MH, Carver CS, Lechner SC, Penedo FJ, McCullough ME, Gluck S, Derhagopian RP, Blomberg BB (2011) Stress management skills and reductions in serum cortisol across the year after surgery for non-metastatic breast cancer. Cogn Ther Res 35:595–600. https://doi.org/10.1007/s10608-011-9398-3

    Article  Google Scholar 

  126. Bennett MI, Bagnall A-M, Closs JS (2009) How effective are patient-based educational interventions in the management of cancer pain? Systematic review and meta-analysis. Pain 143:192–199. https://doi.org/10.1016/j.pain.2009.01.016

    Article  PubMed  Google Scholar 

  127. Tatrow K, Montgomery GH (2006) Cognitive behavioral therapy techniques for distress and pain in breast cancer patients: a meta-analysis. J Behav Med 29:17–27. https://doi.org/10.1007/s10865-005-9036-1

    Article  PubMed  Google Scholar 

  128. Devine EC (2003) Meta-analysis of the effect of psychoeducational interventions on pain in adults with cancer. Oncol Nurs Forum 30:75–89. https://doi.org/10.1188/03.ONF.75-89

    Article  PubMed  Google Scholar 

  129. Johannsen M, O’Connor M, O’Toole MS et al (2016) Efficacy of mindfulness-based cognitive therapy on late post-treatment pain in women treated for primary breast Cancer: a randomized controlled trial. J Clin Oncol 34:3390–3399. https://doi.org/10.1200/JCO.2015.65.0770

    Article  PubMed  Google Scholar 

  130. Johannsen M, O’Connor M, O’Toole MS, Jensen AB, Zachariae R (2017) Mindfulness-based cognitive therapy and persistent pain in women treated for primary breast cancer. Clin J Pain 34:1. https://doi.org/10.1097/AJP.0000000000000510

    Article  Google Scholar 

  131. Robb KA, Williams JE, Duvivier V, Newham DJ (2006) A pain management program for chronic cancer-treatment-related pain: a preliminary study. J Pain 7:82–90. https://doi.org/10.1016/j.jpain.2005.08.007

    Article  PubMed  Google Scholar 

  132. Gilpin HR, Keyes A, Stahl DR, Greig R, McCracken LM (2017) Predictors of treatment outcome in contextual cognitive and behavioral therapies for chronic pain: a systematic review. J Pain 18:1153–1164. https://doi.org/10.1016/j.jpain.2017.04.003

    Article  PubMed  Google Scholar 

  133. Davis MC, Zautra AJ (2013) An online mindfulness intervention targeting socioemotional regulation in fibromyalgia: results of a randomized controlled trial. Ann Behav Med 46:273–284. https://doi.org/10.1007/s12160-013-9513-7

    Article  PubMed  Google Scholar 

  134. Davis MC, Zautra AJ, Wolf LD et al (2015) Mindfulness and cognitive–behavioral interventions for chronic pain: differential effects on daily pain reactivity and stress reactivity. J Consult Clin Psychol 83:24–35. https://doi.org/10.1037/a0038200

    Article  PubMed  Google Scholar 

  135. Zautra AJ, Davis MC, Reich JW et al (2008) Comparison of cognitive behavioral and mindfulness meditation interventions on adaptation to rheumatoid arthritis for patients with and without history of recurrent depression. J Consult Clin Psychol 76:408–421. https://doi.org/10.1037/0022-006X.76.3.408

    Article  PubMed  Google Scholar 

  136. Trompetter HR, Bohlmeijer ET, Lamers SMA, Schreurs KMG (2016) Positive psychological wellbeing is required for online self-help acceptance and commitment therapy for chronic pain to be effective. Front Psychol 7:353. https://doi.org/10.3389/fpsyg.2016.00353

    Article  PubMed  PubMed Central  Google Scholar 

  137. Wetherell JL, Petkus AJ, Alonso-Fernandez M et al (2016) Age moderates response to acceptance and commitment therapy vs. cognitive behavioral therapy for chronic pain. Int J Geriatr Psychiatry 31:302–308. https://doi.org/10.1002/gps.4330

    Article  PubMed  Google Scholar 

  138. Garssen B, Boomsma MF, de Jager Meezenbroek E et al (2013) Stress management training for breast cancer surgery patients. Psychooncology 22:572–580. https://doi.org/10.1002/pon.3034

    Article  PubMed  Google Scholar 

  139. Epstein RM, Duberstein PR, Fenton JJ, Fiscella K, Hoerger M, Tancredi DJ, Xing G, Gramling R, Mohile S, Franks P, Kaesberg P, Plumb S, Cipri CS, Street RL Jr, Shields CG, Back AL, Butow P, Walczak A, Tattersall M, Venuti A, Sullivan P, Robinson M, Hoh B, Lewis L, Kravitz RL (2016) Effect of a patient-centered communication intervention on oncologist-patient communication, quality of life, and health care utilization in advanced cancer. JAMA Oncol 3:92–100. https://doi.org/10.1001/jamaoncol.2016.4373

    Article  Google Scholar 

  140. Oldenmenger WH, Sillevis Smitt PAE, van Montfort CAGM et al (2011) A combined pain consultation and pain education program decreases average and current pain and decreases interference in daily life by pain in oncology outpatients: a randomized controlled trial. Pain 152:2632–2639. https://doi.org/10.1016/j.pain.2011.08.009

    Article  PubMed  Google Scholar 

  141. Kravitz RL, Tancredi DJ, Jerant A, Saito N, Street RL, Grennan T, Franks P (2012) Influence of patient coaching on analgesic treatment adjustment: secondary analysis of a randomized controlled trial. J Pain Symptom Manag 43:874–884. https://doi.org/10.1016/j.jpainsymman.2011.05.020

    Article  Google Scholar 

  142. Howell D, Harth T, Brown J, Bennett C, Boyko S (2017) Self-management education interventions for patients with cancer: a systematic review. Support Care Cancer 25:1323–1355. https://doi.org/10.1007/s00520-016-3500-z

    Article  PubMed  Google Scholar 

  143. Rustøen T, Valeberg BT, Kolstad E, Wist E, Paul S, Miaskowski C (2014) A randomized clinical trial of the efficacy of a self-care intervention to improve Cancer pain management. Cancer Nurs 37:34–43. https://doi.org/10.1097/NCC.0b013e3182948418

    Article  PubMed  Google Scholar 

  144. Jahn P, Kuss O, Schmidt H et al (2014) Improvement of pain-related self-management for cancer patients through a modular transitional nursing intervention: a cluster-randomized multicenter trial. Pain 155:746–754. https://doi.org/10.1016/j.pain.2014.01.006

    Article  PubMed  Google Scholar 

  145. Adam R, Burton CD, Bond CM, de Bruin M, Murchie P (2017) Can patient-reported measurements of pain be used to improve cancer pain management? A systematic review and meta-analysis. BMJ Support Palliat Care 7:00.1–00.0000. https://doi.org/10.1136/bmjspcare-2016-001137

  146. Wilkie D, Berry D, Cain K et al (2010) Effects of coaching patients with lung cancer to report cancer pain. West J Nurs Res 32:23–46. https://doi.org/10.1177/0193945909348009

    Article  PubMed  PubMed Central  Google Scholar 

  147. Cleeland CS, Wang XS, Shi Q et al (2011) Automated symptom alerts reduce postoperative symptom severity after cancer surgery: a randomized controlled clinical trial. J Clin Oncol 29:994–1000. https://doi.org/10.1200/JCO.2010.29.8315

    Article  PubMed  PubMed Central  Google Scholar 

  148. Manzano A, Ziegler L, Bennett M (2014) Exploring interference from analgesia in patients with cancer pain: a longitudinal qualitative study. J Clin Nurs 23:1877–1888

    Article  PubMed  Google Scholar 

  149. Street RL, Tancredi DJ, Slee C et al (2014) A pathway linking patient participation in cancer consultations to pain control. Psychooncology 23:1111–1117. https://doi.org/10.1002/pon.3518

    Article  PubMed  Google Scholar 

  150. Fulcrand J, Delvoye J, Boursier A, Evrard M, Dujardin L, Ferret L, Barrascout E, Lemaire A (2018) Place du pharmacien clinicien dans la prise en charge des patients en soins palliatifs. J Pain Symptom Manag 56:e101–e102. https://doi.org/10.1016/j.jpainsymman.2018.10.343

    Article  Google Scholar 

  151. Kroenke K, Theobald D, Wu J, Norton K, Morrison G, Carpenter J, Tu W (2010) Effect of telecare management on pain and depression in patients with cancer. JAMA 304:163–171. https://doi.org/10.1001/jama.2010.944

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  152. Adam R, de Bruin M, Burton CD, Bond CM, Giatsi Clausen M, Murchie P (2018) What are the current challenges of managing cancer pain and could digital technologies help? BMJ Support Palliat Care 8:204–212. https://doi.org/10.1136/bmjspcare-2016-001232

    Article  PubMed  Google Scholar 

  153. Kwon JH (2014) Overcoming barriers in cancer pain management. J Clin Oncol 32:1727–1733. https://doi.org/10.1200/JCO.2013.52.4827

    Article  PubMed  Google Scholar 

  154. Kasasbeh MAM, McCabe C, Payne S (2017) Action learning: an effective way to improve cancer-related pain management. J Clin Nurs 26:3430–3441. https://doi.org/10.1111/jocn.13709

    Article  PubMed  Google Scholar 

  155. Physical Activities Guidelines Advisory Committee (2008) Physical activity guidelines advisory committee report. US Department of Health and Human Services (ed), Washington DC

    Google Scholar 

  156. Buffart LM, Galvão DA, Brug J et al (2014) Evidence-based physical activity guidelines for cancer survivors: current guidelines, knowledge gaps and future research directions. Cancer Treat Rev 40:327–340. https://doi.org/10.1016/j.ctrv.2013.06.007

    Article  CAS  PubMed  Google Scholar 

  157. Campbell KL, Neil SE, Winters-Stone KM (2012) Review of exercise studies in breast cancer survivors: attention to principles of exercise training. Br J Sports Med 46:909–916. https://doi.org/10.1136/bjsports-2010-082719

    Article  PubMed  Google Scholar 

  158. Sundaramurthi T, Gallagher N, Sterling B (2017) Cancer-related acute pain: a systematic review of evidence-based interventions for putting evidence into practice. Clin J Oncol Nurs 21:13–30

    Article  PubMed  Google Scholar 

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Acknowledgments

Support was provided by Xavier Amores, M.D. and Viorica Braniste, M.D. and Ph.D. (Kyowa Kirin), and Robert Campos Oriola, Ph.D, and Marie-Odile Barbaza, MD, (Auxesia) for manuscript preparation.

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Authors and Affiliations

  1. Pain management centre, Grenoble-Alpes University Hospital, Grenoble, France

    Caroline Maindet

  2. Department of supportive care, Institut Curie, PSL Research University, Paris, France

    Alexis Burnod

  3. Anaesthesia-intensive care department, Cancer Centre Georges François Leclerc, Dijon, France

    Christian Minello

  4. Pain management unit, Saint-Louis Hospital, Paris, France

    Brigitte George

  5. Pain management unit, Mutualist Clinic of la Porte-de-l’Orient, Lorient, France

    Gilles Allano

  6. Oncology and medical specialties department, Valenciennes General Hospital, Valenciennes, France

    Antoine Lemaire

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Conflict of interest

Caroline Maindet reports non-financial support from Kyowa Kirin, during the conduct of the submitted work; personal fees and non-financial support from Mundipharma; and non-financial support from Kyowa Kirin, Grunenthal, Hospira, Takeda, and Janssen Cilag, outside the submitted work. Alexis Burnod reports non-financial support from Kyowa Kirin, during the conduct of the submitted work and non-financial support from Kyowa Kirin, outside the submitted work. Christian Minello reports non-financial support from Kyowa Kirin, during the conduct of the submitted work; personal fees and non-financial support from Takeda; and non-financial support from Kyowa Kirin, Mundi Pharma, Mylan Pharma, and Grunenthal, outside the submitted work. Brigitte George reports non-financial support from Kyowa Kirin, during the conduct of the submitted work; personal fees and non-financial support from Mundipharma, non-financial support from Grunenthal and Kyowa Kirin, outside the submitted work; participation to a clinical study without honoraria from Bouchara. Gilles Allano reports non-financial support from Kyowa Kirin, during the conduct of the submitted work; personal fees and non-financial support from Grunenthal, Mundipharma, and Medtronic; and non-financial support from Kyowa Kirin, outside the submitted work. Antoine Lemaire reports non-financial support from Kyowa Kirin France, during the conduct of the submitted work; personal fees and non-financial support from Kyowa Kirin International, Mundi Pharma, Grunenthal, and Takeda; personal fees from Mylan; and non-financial support from Kyowa Kirin France, Archimèdes Pharma, Teva, Prostrakan, outside the submitted work.

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Maindet, C., Burnod, A., Minello, C. et al. Strategies of complementary and integrative therapies in cancer-related pain—attaining exhaustive cancer pain management. Support Care Cancer 27, 3119–3132 (2019). https://doi.org/10.1007/s00520-019-04829-7

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