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Immunohistochemical investigations on the course of astroglial GFAP expression following human brain injury

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Abstract

The course of GFAP expression by astrocytes has been immunohistochemically investigated during the first 30 weeks after human brain injury. In order to provide reliable data for a forensic wound age estimation, a quantitative morphometric analysis was performed considering the different topographic regions of the cortex as well as of the white matter. Compared to the GFAP immunoreactivity in unaltered control tissue, significantly increased numbers of GFAP positive astroglial cells could be detected adjacent to the cortical contusion from 1 day up to 4 weeks after brain injury.

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Authors and Affiliations

  1. Department of Legal Medicine, University of Erlangen-Nürnberg, Universitätsstrasse 22, D-91054 Erlangen, Germany, , , , , , DE

    R. Hausmann & P. Betz

  2. Department of Pathology, Klinikum Nürnberg-Süd, Breslauer Strasse 201, D-90471 Nürnberg, Germany, , , , , , DE

    R. Rieß

  3. Department of Legal Medicine, Medizinische Hochschule Hannover, Carl-Neuberg Strasse 1, D-30625 Hannover, Germany, , , , , , DE

    A. Fieguth

Authors
  1. R. Hausmann
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  2. R. Rieß
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  3. A. Fieguth
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  4. P. Betz
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Received: 10 November 1998 / Received in revised form: 26 February 1999

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Hausmann, R., Rieß, R., Fieguth, A. et al. Immunohistochemical investigations on the course of astroglial GFAP expression following human brain injury. Int J Leg Med 113, 70–75 (2000). https://doi.org/10.1007/PL00007711

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  • DOI: https://doi.org/10.1007/PL00007711

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