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Ultrastructural aspects on iodination and hormone secretion in the thyroid gland

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References

  1. De Nayer P., Vassart G. Structure and biosynthesis of thyroglobulin. In: De Visscher M. (Ed.), Comprehensive endocrinology. The thyroid gland. Raven Press, New York, 1980, p. 21.

    Google Scholar 

  2. Ekholm R. Iodination of thyroglobulin: An intracellular or extracellular process. Mol. Cell. Endocrinol. 24: 141, 1981.

    Article  PubMed  CAS  Google Scholar 

  3. Ekholm R. Thyroid gland Anatomy and development. In: DeGroot L.J. (Ed.), Endocrinology. Grune and Stratton, New York, 1979, vol. 1, p. 305.

    Google Scholar 

  4. Ericson L.E. Exocytosis and endocytosis in the thyroid gland. Mol. Cell. Endocrinol. 22: 1, 1981.

    Article  PubMed  CAS  Google Scholar 

  5. Fujita H. Fine structure of the thyroid gland. Int. Rev. Cytol. 40: 197, 1975.

    Article  PubMed  CAS  Google Scholar 

  6. Nunez J. Iodination and thyroid hormone synthesis. In: De Visscher M. (Ed.), Comprehensive endocrinology. The thyroid gland. Raven Press, New York, 1980, p. 39.

    Google Scholar 

  7. Taurog A. Thyroid gland. Hormone synthesis. In: DeGroot L.J. (Ed.), Endocrinology. Grune and Stratton, New York, 1979, vol. 1, p. 331.

  8. Van den Hove-Vandenbroucke M.F. Secretion of thyroid hormones. In: De Visscher M. (Ed.), Comprehensive endocrinology. The thyroid gland. Raven Press, New York, 1980, p. 61.

    Google Scholar 

  9. Wollman S.H. Structure of the thyroid gland. In: De Visscher M. (Ed.), Comprehensive endocrinology. The thyroid gland. Raven Press, New York, 1980, p. 1.

    Google Scholar 

  10. Wollman S.H., Loewenstein J.E. Rates of colloid droplet and apical vesicle production and membrane turnover during thyroglobulin secretion and resorption. Endocrinology 93: 248, 1973.

    Article  PubMed  CAS  Google Scholar 

  11. Ericson L.E., Engström G. Quantitative electron microscopic studies on exocytosis and endocytosis in the thyroid follicle cell. Endocrinology 103: 883, 1978.

    Article  PubMed  CAS  Google Scholar 

  12. Pavlovic-Hournac M., Delbauffe D. In vivo incorporation of labelled amino acid into different protein fractions of the rat thyroid gland. Horm. Metab. Res. 6: 196, 1974.

    Article  PubMed  CAS  Google Scholar 

  13. Smeds S. A microgel electrophoretic analysis of the colloid protein in single rat thyroid follicles. I. The quantitative protein composition of the colloid in normal thyroids. Endocrinology 91: 1288, 1972.

    Article  PubMed  CAS  Google Scholar 

  14. Whur P., Herscovics A., Leblond C.P. Radioautographic visualization of the incorporation of galactose-[3H] and mannose-[3H] by rat thyroids in vitro in relation to the stages of thyroglobulin synthesis. J. Cell Biol. 43: 289, 1969.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  15. Haddad A., Smith M.D., Herscovics A., Nadler N.J., Leblond C.P. Radioactive study of in vivo and in vitro incorporation of fucose-[3H] into thyroglobulin by rat thyroid follicular cells. J. Cell Biol. 49: 856, 1971.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  16. Bjorkman U., Ekholm R., Elmqvist L.-G., Ericson L.E., Melander A., Smeds S. Induced unidirectional transport of protein into the thyroid follicular lumen. Endocrinology 95: 1506, 1974.

    Article  PubMed  CAS  Google Scholar 

  17. Björkman U., Ekholm R., Ericson L.E., Öfverholm T. Transport of thyroglobulin and peroxidase in the thyroid follicle cell. Mol. Cell. Endocrinol. 5: 3, 1976.

    Article  PubMed  Google Scholar 

  18. Berg G., Björkman U., Ekholm R. The structure of newly synthesized intracellular thyroglobulin molecules. Mol. Cell. Endocrinol. 20: 87, 1980.

    Article  PubMed  CAS  Google Scholar 

  19. Feracci H., Bernadac A., Hovsepian S., Fayet G., Maroux S. Aminopeptidase N is a marker for the apical pole of porcine thyroid epithelial cells in vivo and in culture. Cell Tissue Res. 221: 137, 1981.

    Article  PubMed  CAS  Google Scholar 

  20. Björkman U., Ekholm R., Denef J.F. Cytochemical localization of hydrogen peroxide in isolated thyroid follicles. J. Ultrastruct. Res. 74: 105, 1981.

    Article  PubMed  Google Scholar 

  21. Smeds S. A microgel electrophoretic analysis of the colloid proteins in single rat thyroid follicles. II. The protein concentration of the colloid in single rat thyroid follicles. Endocrinology 91: 1300, 1972.

    Article  PubMed  CAS  Google Scholar 

  22. Smeds S., Ekholm R., Ericson L.E. Protein concentration of the rat thyroid colloid during thyroxine treatment. Acta Endocrinol.: (Kbh.) 84: 768, 1977.

    CAS  Google Scholar 

  23. Köchli H.P., Studer H., von Gruenigen C., Kohler H. The impact of TSH on diffusion of thyroglobulin through follicular lumina: Possible relation to hormone formation. In: Stockigt J.R., Nagataki S. (Eds.), Thyroid Research VIII. Australian Academy of Science, Canberra, 1980, p. 145.

    Google Scholar 

  24. Öfverholm T., Ericson L.E. Intraluminal iodination of thyroglobulin. Endocrinology 1983, (in press).

    Google Scholar 

  25. Van Sande J., Ketelbant-Balasse P., Grenier G., Dumont J.E. Uncoupling by cooling of secretion and cyclic AMP accumulation in stimulated dog thyroid slices. Endocrinology 102: 576, 1978.

    Article  PubMed  Google Scholar 

  26. Rocmans P.A., Ketelbant-Balasse P., Dumont J.E., Nève P. Hormonal secretion by hyperactive thyroid cells is not secondary to apical phagocytosis. Endocrinology 103: 1834, 1978.

    Article  PubMed  CAS  Google Scholar 

  27. Ketelbant-Balasse P., Rodesch F., Nève P., Pasteeis J.M. Scanning electron microscope observations of apical surfaces of dog thyroid cells. Exp. Cell Res. 79: 111, 1973.

    Article  CAS  Google Scholar 

  28. Wetzel B.K., Spicer S.S., Wollman S.H. Changes in fine structure and acid phosphatase localization in rat thyroid cells following thyrotropin administration. J. Cell Biol. 25: 593, 1965.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  29. Ekholm R., Smeds S. On dense bodies and droplets in the follicular cells of the guinea pig thyroid. J. Ultrastruct. Res. 76: 71, 1966.

    Article  Google Scholar 

  30. Seljelid R., Nakken K.F. Endocytosis of thyroglobulin and the release of thyroid hormone. Scand. J. Clin. Lab. Invest. 22: (Suppl. 106), 125, 1968.

    Article  CAS  Google Scholar 

  31. Engström G., Ericson L.E. Effect of graded doses of thyrotropin on exocytosis and early phase of endocytosis in the rat thyroid. Endocrinology 108: 399, 1981.

    Article  PubMed  Google Scholar 

  32. Engström G. Activation of follicles and follicle cells by different doses of TSH. Ann. Endocrinol. (Paris) 42: 50 A, 1981.

    Google Scholar 

  33. Ericson LE., Ring K.M., Öfverholm T. Selective macropinocytosis of thyroglobulin in rat thyroid follicles. Endocrinology 1983, (in press).

    Google Scholar 

  34. Tice L.W., Wollman S.H. Ultrastructural localization of peroxidase on pseudo-pods and other structures of the typical thyroid epithelial cell. Endocrinology 94: 1555, 1974.

    Article  PubMed  CAS  Google Scholar 

  35. Denef J.F., Ekholm R. Membrane labeling with cationized ferritin in isolated thyroid follicles. J. Ultrastruct. Res. 71: 203, 1980.

    Article  PubMed  CAS  Google Scholar 

  36. Nève P., Ketelbant-Balasse P., Willems C., Dumont J.E. Effects of inhibitors of microtubules and microfilaments on dog thyroid slices in vitro. Exp. Cell Res. 74: 227, 1972.

    Article  PubMed  Google Scholar 

  37. Wolff J., Williams J.A. The role of microtubules and microfilaments in thyroid secretion. Recent Prog. Horm. Res. 29: 229, 1973.

    PubMed  CAS  Google Scholar 

  38. Gabrion J., Travers F., Benyamin Y., Sentein P., van Thoai N. Characterization of actin microfilaments at the apical pole of thyroid cells. Cell. Biol. Int. Rep. 4: 59, 1982.

    Article  Google Scholar 

  39. Ekholm R., Ericson L.E., Josefsson J.O., Melander A. In vivo action of vinblastine on thyroid ultrastructure and hormone secretion. Endocrinology 94: 641, 1974.

    Article  PubMed  CAS  Google Scholar 

  40. Ericson L.E. Vinblastine-induced inhibition of protein transport in the mouse thyroid in vivo. Endocrinology 106: 833, 1980.

    Article  PubMed  CAS  Google Scholar 

  41. Unger J., Boeynaems J.M., Ketelbant-Balasse P., Dumont J.E., Mockel J. Kinetic of dog thyroid secretion in vitro. Endocrinology 103: 1597, 1978.

    Article  PubMed  CAS  Google Scholar 

  42. Seljelid R. Endocytosis in thyroid follicle cells II. A microinjection study of the origin of colloid droplets. J. Ultrastruct. Res. 17: 401, 1967.

    Article  PubMed  CAS  Google Scholar 

  43. Herzog V., Miller F. Membrane retrieval in epithelial cells of isolated thyroid follicles. Eur. J. Cell Biol. 19: 203, 1979.

    PubMed  CAS  Google Scholar 

  44. Consiglio E., Salvatore G., Rail J.E., Kohn L.D. Thyroglobulin interactions with thyroid plasma membranes. The existence of specific receptors and their potential role. J. Biol. Chem. 254: 5065, 1979.

    PubMed  CAS  Google Scholar 

  45. Unger J., Boeynaems J.M., van Herle A., van Sande J., Rocmans P., Mockel J. In vitro nonbutanol-extractable iodine release in dog thyroid. Endocrinology 105: 225, 1979.

    Article  PubMed  CAS  Google Scholar 

  46. Herzog V., Miller F. Structural and functional polarity of inside-out follicles from pig thyroid glands. Eur. J. Cell Biol. 24: 74, 1981.

    PubMed  CAS  Google Scholar 

  47. Ekholm R., Engström G., Ericson L.E., Melander A. Exocytosis of protein into the thyroid follicle lumen: an early effect of TSH. Endocrinology 97: 337, 1975.

    Article  PubMed  CAS  Google Scholar 

  48. Ericson LE., Johansson B.R. Early effects of thyroid stimulating hormone (TSH) on exocytosis and endocytosis in the thyroid. Acta Endocrinol. (Kbh.) 86: 112, 1977.

    CAS  Google Scholar 

  49. Ericson L.E., Johanson V. Dependence of stimulated endocytosis on membrane available in exocytotic vesicles in thyroid follicle cells. Europ. J. Cell Biol. 22: 183, 1980.

    Google Scholar 

  50. Weibel E.R. Stereological methods. I. Practical methods for biological morphometry. Academic Press, London, 1979.

    Google Scholar 

  51. Herzog V., Miller F. Membrane retrieval in secretory cells. Morphological evidence for participation of Golgi cisternae in internalization of plasma membrane following stimulated exocytosis. In: Hopkins C.R., Duncan C.J. (Eds.), Secretory mechanisms. Symposia of the Society for Experimental Biology. XXXIII. Cambridge University Press, Cambridge, 1979, p. 101.

    Google Scholar 

  52. Ericson L.E., Engström G., Ekholm R. Effect of long-term thyroxine treatment on thyrotropin-induced exocytosis and endocytosis in the rat thyroid. Endocrinology 104: 704, 1979.

    Article  PubMed  CAS  Google Scholar 

  53. Ericson L.E., Engström G., Ekholm R. Effect of cycloheximide on thyrotropin-stimulated endocytosis in the rat thyroid. Endocrinology 106: 1119, 1980.

    Article  PubMed  CAS  Google Scholar 

  54. Ericson L.E., Johanson V. Turnover of exocytotic vesicles in rat thyroid follicle cells. Ann. Endocrinol. (Paris) 42: 77A, 1981.

    Google Scholar 

  55. Tachiwaki O., Wollman S.H. Shedding of dense cell fragments into the follicular lumen early in involution of the hyperplastic thyroid gland. Lab. Invest. 47: 91, 1982.

    PubMed  CAS  Google Scholar 

  56. Öfverholm T., Nilsson M., Ericson L.E. Shedding of apical plasma membrane in mouse thyroid follicles. Ann. Endocrinol. (Paris) 43: 47A, 1982.

    Google Scholar 

  57. Ekholm R., Wollman S.H. Site of iodination in the rat thyroid gland deduced from electron microscopic autoradiographs. Endocrinology 97: 1432, 1975.

    Article  PubMed  CAS  Google Scholar 

  58. Ericson L.E. Intracellular lumens in thyroid follicle cells of thyroxine-treated rats. J. Ultrastruct. Res. 69: 297, 1979.

    Article  PubMed  CAS  Google Scholar 

  59. Ahn C.S., Rosenberg I.N. Prompt stimulation of the organic binding of iodine in the thyroid by adenosine 3′–5′-phosphate in vivo. Proc. N.Y. Acad. Sei. USA 60: 830, 1968.

    Article  CAS  Google Scholar 

  60. Ekholm R., Ericson L.E., Engström G., Öfverholm T. Thyroglobulin exocytosis and iodination. Proc. 7th Internat. Thyroid Conf., Boston, 1975. Excerpta Medica Internat. Congress Series 378: 130, 1976.

    Google Scholar 

  61. Ekholm R., Björkman U., Ericson L.E. Effect of TSH on thyroglobulin iodination in the rat thyroid after long-term thyroxine treatment. Ann. Endocrinol. (Paris) 38: 72A, 1977.

    Google Scholar 

  62. Björkman U., Ekholm R., Ericson L.E. Effects of TSH on thyroglobulin exocytosis and iodination in the rat thyroid gland. Endocrinology 102: 460, 1978.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Anatomy, University of Göteborg, Box 33031, S-40033, Gothenburg, Sweden

    L. E. Ericson

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Sir Harington-de Visscher Prize Lecture 1982 of the European Thyroid Association.

The experimental work included in this presentation was supported by grant 12X-537 from the Swedish Medical Research Council.

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Ericson, L.E. Ultrastructural aspects on iodination and hormone secretion in the thyroid gland. J Endocrinol Invest 6, 311–324 (1983). https://doi.org/10.1007/BF03347597

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