Abstract
To verify the greater prevalence of circulating thyroid hormone autoantibodies (THAb) in primary Sjögren syndrome (SS) vs Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), we measured THAb in the serum of patients with these 3 diseases who were sampled from 1998–1999 (no.=20, 88, 25) and 1990–1992 (no.=13, 75, 31). Patients with rheumatoid arthritis (RA) (no.=23 and 16) and other collagenoses (no.=20 and 16) were also studied. A third series of patients with these 5 diseases was studied from 1975–1982, and data have been taken into account. THAb were detected using a specific radioimmunoprecipitation method, and their presence was correlated with the presence of TG antibodies (TGAb). We found that IgG antibodies against T3, T4 or both were present with these pre-valences in the 1975–1982, 1990–1992 and 1998–1999 series: HT=1, 4, 20%; GD=2, 6, 32%; SS=20, 31, 50%; RA=0, 12, 26%; other collagenoses=0, 0, 0%. The majority of the Sjögren or arthritis cases positive for THAb were negative for TGAb, while the opposite was true for the 2 autoimmune thyroid diseases. We conclude that prevalence of THAb in the 2 non-thyroid autoimmune diseases is greater than in the 2 thyroid autoimmune diseases. In addition, prevalence of THAb is increasing over time regardless of disease. Molecular similarity between extra-thyroid connective proteins (specifically associated to primary SS and RA) and iodinated regions of TG, and an increased preponderance of environmental factors as triggers of autoimmune diseases might account for our findings.
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References
Benvenga S., Trimarchi F., Robbins J. Circulating thyroid autoantibodies. J. Endocrinol. Invest. 1987, 10: 605–619.
Elsing C., Pilar K., Hehrmann R. Haufgeikt und Klinische Bedeutung Zirkkiliender Autoantikorper gegen Schildrussenhormone. Akt. Endokr. Stoffw. 1991, 12: 49–56.
Larsen P.R., Davies T.F., Hay I.D. The thyroid gland. In: Wilson J.D., Foster D.W., Kronenberg H.M., Larsen P.R. (Eds.), Williams Textbook of Endocrinology. W.B. Saunders, Philadelphia, 1998, p. 389.
Trimarchi F., Benvenga S., Costante G., et al. Identification and characterization of circulating thyroid hormone autoantibodies in thyroid diseases, in autoimmune non-thyroid illnesses and in lymphoreticular disorders. J. Endocrinol. Invest. 1983, 6: 203–209.
Perez E.B., Kraus A., Lopez G., Cifuentes M., Alarcon-Segovia D. Autoimmune thyroid diseases in primary Sjögren syndrome. Am. J. Med. 1995, 99: 480–484.
Benvenga S., Bartolone L., Squadrito S., Trimarchi F. Thyroid hormone autoantibodies elicited by diagnostic fine-needle biopsy. J. Clin. Endocrinol. Metab. 1997, 82: 4217–4223.
Vitali C., Bombardieri S., Moutsopoulos H.M., et al. for the European Community Study Group on the Diagnostic Criteria for Sjögren sindrome. Preliminary criteria for the classification of Sjögren syndrome. Results of a prospective concerted action supported by the European Community. Arthritis Rheum. 1993, 36: 340–347.
Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum. 1980, 23: 581–590.
Bohan A., Peter J.B. Polymiositis and dermatomyiositis. Part I and part II. N. Engl. J. Med. 1975, 292: 344–403.
Weetman A.P. Chronic autoimmune thyroiditis. In: Bravermann L.E., Utiger R.D. (Eds.), Werner and Ingbar’s The Thyroid. Lippincott-Raven, Philadelphia, 1996, p. 738.
Komaki T., Sakata S., Nakamura S., Kamiko K., Miura K. Two cases associated with thyroid hormone autoantibodies. In: Walfish P.G., Wall J.R., Volpe R. (Eds.), Autoimmunity and the thyroid. Academic Press, Orlando, 1985, p. 403.
Lipsky P.E. Artrite reumatoide. In: Isselbacher K.J., Braunwald E., Wilson J.D., Martin J.B., Fauci A.S., Kasper D.L. (Eds.), Harrison Principi di Medicina Interna. McGraw-Hill, Milan, 1995, p. 1868.
Arnett F.C., Edworthy S.M., Bloch D.A., et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988, 31: 315–324.
Tan E.M., Cohen A.S., Fries J.F., et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982, 25: 1271–1277.
Moutsopoulos H.M. Sindrome di Sjögren. In: Isselbacher K.J., Braunwald E., Wilson J.D., Martin J.B., Fauci A.S., Kasper D.L. (Eds.), Harrison Principi di Medicina Interna. McGraw-Hill, Milan, 1995, p. 1885.
Fye K.H., Sack K.E. Rheumatic diseases. In: Stites D.P., Stobo J.D., Fudenberg H.H., Wells J.V. (Eds.), Basic and Clinical Immunology. Lange Medical Publications, Los Altos, 1982, p. 423.
Dunn J.T., Dunn A.D. Thyroglobulin: chemistry, biosynthesis and proteolysis. In: Bravermann L.E., Utiger R.D. (Eds.), Werner and Ingbar’s The Thyroid. Lippincott-Raven, Philadelphia, 1996, p. 90.
Kuppers R.C., Bresler H.S., Burek C.L., Gleason S.L., Rose N.R. Immunodominant determinants of thyroglobulin-associated with autoimmune thyroiditis. In: Bona C.A., Kaushick A.K. (Eds.), Molecular immunobiology of self-reactivity. Marcel Dekker, New York, 1992, p. 247.
Martin D.W. Jr. Glycoproteins, proteoglycans and glycosaminoglycans. In: Martin D.W. Jr, Mayes P.A., Rodwell D.W., Granner D.K. (Eds.), Harper’s review of Biochemistry. Lange Medical Publications, Los Altos, 1985, p. 464.
Brucker-Davis F. Effects of environmental synthetic chemicals on thyroid function. Thyroid 1998, 8: 827–856.
Rasmussen A.K., Hartoft-Nielsen M.L., Feldt-Rasmussen U. Models to study the pathogenesis of thyroid autoimmunity. Biochimie 1999, 81: 511–515.
Rhodus N.L. Sjögren’s syndrome. Quintessence Intl. 1999, 30: 689–699.
Danieli G., Gabrielli A., Pomponio G. Etiologia e patogenesi dell’artrite reumatoide. In: Dammacco F., Danieli G. (Eds.), Clinica Immunologica. Il Pensiero Scientifico, Roma, 1997, p. 189.
Benvenga S., Ruggeri R.M., Lapa D., Russo A., Campenni A., Trimarchi F. The current presentation of Hashimoto’s thyroiditis is different from that of the 1970’s. 12th International Thyroid Congress, Kyoto (Japan), October 22–27, 2000. Endocr. J. 2000, 47 (Abstract: 192 P-345/D) (Suppl.): 192.
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An erratum to this article is available at http://dx.doi.org/10.1007/BF03345072.
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Ruggeri, R.M., Galletti, M., Mandolfino, M.G. et al. Thyroid hormone autoantibodies in primary Sjögren syndrome and rheumatoid arthritis are more prevalent than in autoimmune thyroid disease, becoming progressively more frequent in these diseases. J Endocrinol Invest 25, 447–454 (2002). https://doi.org/10.1007/BF03344036
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DOI: https://doi.org/10.1007/BF03344036