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Serum superoxide dismutase and malondialdehyde levels in a group of Chinese patients with age-related macular degeneration

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Abstract

Background and aims: The aim of this study was to investigate superoxide dismutase (SOD) activity together with malondialdehyde (MDA) levels in a group of Chinese patients with age-related macular degeneration (AMD). Methods: Serum SOD activity and MDA levels were analysed in 56 AMD patients with subtypes (early dry, geographic atrophy, and wet) and 34 healthy controls matched with age and sex. Results: Serum MDA levels were significantly higher in AMD (3.68±1.06 nmol/mL) than in controls (2.83±0.43 nmol/mL; p=0.000), and was significantly higher in wet AMD (3.79±0.79 nmol/mL) than in early dry AMD (3.26±0.99 nmol/mL; p=0.038). Serum SOD activity was significantly higher in AMD (87.12±13.22 U/mL) than in controls (79.91±11.80 U/mL; p=0.012), and slightly higher in wet AMD (89.52±16.25 U/mL) than in GA (83.62+_9.75 U/mL; p=0.275) and early dry AMD (81.64±18.90 U/mL; p=0.093). There was a positive correlation between serum MDA levels and SOD activities in AMD patients and controls (r=0.320, p=0.002). Conclusions: The observed increase in SOD activity in our study may be related to increased MDA levels, as a compensatory regulation in response to oxidative stress in AMD patients. The present data also demonstrate that oxido-reduction disturbance may be hypothesized in the pathogenesis of AMD.

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Authors and Affiliations

  1. School of Public Health, China Medical University, Shenyang, 110001, China

    Lihong Jia, Youdan Dong, Hongmei Yang, Xingyue Pan & Lingling Zhai

  2. Shenyang AIER Ophthalmology Hospital, Shenyang, China

    Rui Fan

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  1. Lihong Jia
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  2. Youdan Dong
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  3. Hongmei Yang
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  4. Xingyue Pan
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Correspondence to Lihong Jia.

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Jia, L., Dong, Y., Yang, H. et al. Serum superoxide dismutase and malondialdehyde levels in a group of Chinese patients with age-related macular degeneration. Aging Clin Exp Res 23, 264–267 (2011). https://doi.org/10.1007/BF03324965

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