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Effect of six candidate genes on early aging in a French population

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Abstract

Background and aims: The objective of this study was to examine the association between an aging indicator previously defined from a nationwide population study, and lipids and apolipoproteins, angiotensin converting enzyme, paraoxonase activities, and six candidate genes related to the aging process. Methods: Two hundred and fifty-six healthy Caucasian men (69.8±4.0 years) were included in the study. Total cholesterol, triglycerides, HDL-cholesterol, lipoprotein(a), apolipoprotein A1, B and E concentrations, and the activities of paraoxonase, arylesterase, and angiotensin-converting enzymes were determined by standardized laboratory methods. A multiplex assay was used to genotype the studied polymorphisms: apolipoprotein E, lipoprotein lipase, paraoxonase, methylenetetrahydrofolate reductase, cystathionine β-synthase and angiotensin-converting enzymes. Results: Paraoxonase polymorphism at codon 192 (Gln/Arg) was the only one significantly associated with the aging indicator, Gln homozygotes being more advanced in aging compared with Arg allele carriers. It was also observed that the aging indicator was positively correlated with serum concentrations of total cholesterol, triglycerides and apolipoprotein B, and negatively with the activities of basal and stimulated paraoxonase and arylesterase. Multiple regression analysis showed that triglycerides and basal paraoxonase activity explain 13.6% of the variance of the aging indicator. Conclusions: Triglyceride concentration and paraoxonase gene and activities may contribute to the aging process. Taking into account the smallness of the sample size, and the poor level of significance due to the implication of paraoxonase polymorphism at codon 192, these results need to be verified in further studies on a greater number of subjects.

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Authors and Affiliations

  1. Laboratoire du Centre de Médecine Préventive and Unité INSERM 525, 2 Rue du Doyen Jacques Parisot, 54500, Vandoeuvre-lès-Nancy, France

    Yongjing Xia, Monique Vincent-Viry, Gérard Siest Ph.D. & Sophie Visvikis

  2. Département Statistique du Centre de Médecine Préventive, Vandoeuvre-lès-Nancy, France

    René Gueguen

Authors
  1. Yongjing Xia
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  2. René Gueguen
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  3. Monique Vincent-Viry
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  4. Gérard Siest Ph.D.
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  5. Sophie Visvikis
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Correspondence to Gérard Siest Ph.D..

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Xia, Y., Gueguen, R., Vincent-Viry, M. et al. Effect of six candidate genes on early aging in a French population. Aging Clin Exp Res 15, 111–116 (2003). https://doi.org/10.1007/BF03324487

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