Abstract
The Michael addition of indoles to α,β-unsaturated electron deficient compounds was catalyzed efficiently at room temperature in acidic micellar solution of sodium dodecyl sulfate (SDS). The substitution on the indole nucleus occurred exclusively at the 3-position in good to excellent yields, and no N-alkylation products were observed.
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Jafari, A.A., Moradgholi, F. & Tamaddon, F. A highly efficient michael addition of indoles to α,β-unsaturated electron-deficient compounds in acidic SDS micellar media. JICS 6, 588–593 (2009). https://doi.org/10.1007/BF03246538
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DOI: https://doi.org/10.1007/BF03246538