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Synthesis and biological study of novel bis-chalcones, bis-thiazines and bis-pyrimidines

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Abstract

A series of novel bis-chalcones 3 were prepared by the reaction of 5,5′-methylene-bis-salicylaldehyde 2 with various acetophenones, subsequent treatment of 3 with thiourea or guanidine resulted to the corresponding bis-thiazines or bispyrimidines in good yields. All the new compounds have been characterized by IR, 1H NMR, MS and elemental analysis. The antibacterial, antifungal and anti-inflammatory activities of the compounds have also been evaluated.

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  1. Department of Chemistry, Kakatiya University, Warangal, 506009, Andhra Pradesh, India

    A. Nagaraj & C. Sanjeeva Reddy

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  1. A. Nagaraj
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  2. C. Sanjeeva Reddy
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Correspondence to C. Sanjeeva Reddy.

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Nagaraj, A., Sanjeeva Reddy, C. Synthesis and biological study of novel bis-chalcones, bis-thiazines and bis-pyrimidines. JICS 5, 262–267 (2008). https://doi.org/10.1007/BF03246116

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