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1H nuclear magnetic resonance study of metronidazole metabolism by perfused rat liver

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Summary

High-resolution1H nuclear magnetic resonance (NMR) spectroscopy at 300 MHz has been used to monitor the metabolism of metronidazole by the perfused rat liver. Samples of perfusate removed at various times during the perfusion show resonances from metronidazole and its major metabolites, as well as those from organic metabolites released from the liver. The major metabolite of metronidazole is shown to be its glucuronide conjugate. Metronidazole metabolism and glucuronide production are both stimulated in livers from rats pretreated with phenobarbitone.

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Authors and Affiliations

  1. School of Biochemistry, University of New South Wales, P.O. Box 1, 2033, Kensington, NSW, Australia

    Helen Allars, Malcolm D. Coleman & Raymond S. Norton

Authors
  1. Helen Allars
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  2. Malcolm D. Coleman
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  3. Raymond S. Norton
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Allars, H., Coleman, M.D. & Norton, R.S. 1H nuclear magnetic resonance study of metronidazole metabolism by perfused rat liver. European Journal of Drug Metabolism and Pharmacokinetics 10, 253–260 (1985). https://doi.org/10.1007/BF03189750

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  • DOI: https://doi.org/10.1007/BF03189750

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