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Scaling of antipyrine intrinsic clearance of unbound drug in 15 mammalian species

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Summary

The intrinsic clearance of unbound drug (CLuint) for antipyrine in 15 mammalian species was characterized by an equation of the form, CLuint=ϕ1 (body weight)ϕ 2 (brain weight)ϕ 3, where thetas are constants. Maximum lifespan potential in mammals can also be characterized by an equation of this form. It is suggested that the set of genetic mechanisms regulating longevity and other constitutional characteristics in species is also linked to rates of drug metabolism. The ability to scale interspecies data in pharmacokinetics is taken as an expression of this design principle.

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Author notes

  1. Harold Boxenbaum

    Present address: Pharmaceutics Seciton, School of Pharmacy, University of Connecticut, Building 5, Veterans Administration Medical Center, 555 Willard Avanue, 06111, Newington, Connecticut, USA

Authors and Affiliations

  1. Behavioral Medicine Research Laboratory, Veterans Administration Medical Center, Newington, Connecticut, USA

    Joanne B. Fertig

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  1. Harold Boxenbaum
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Boxenbaum, H., Fertig, J.B. Scaling of antipyrine intrinsic clearance of unbound drug in 15 mammalian species. European Journal of Drug Metabolism and Pharmacokinetics 9, 177–183 (1984). https://doi.org/10.1007/BF03189622

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  • DOI: https://doi.org/10.1007/BF03189622

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