Summary
In order to aid clinical investigations of metabolism and to study the antiseptic action of Taurolin® , analysis of Taurolidine solutions by Gas Chromatography coupled with Mass Spectrometry and Fourier Transform Infra-Red spectrometry was performed. It was found that the active species is methylol-Taurultam, which was observed as N-amino methyl N-methylol taurine, after ring opening due to high temperatures used in GC analysis. To minimize such uncontrolled thermal decompositions during biological fluid analysis, High Performance Liquid Chromatography was used. Clinical results obtained by this method in human patients are presented.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Reeves D.S., Schweitzer F.A.W. (1973): Prog. Chemotherm. Proc. Int. Congr. Chemotherm., Experimental studies with an antibacterial substance, Taurolin, 8th,2 583–586.
Browne M.K., Leslie G.B., Pfirrmann R.W. (1976): J. Appl. Bacteriol. Taurolin, a new chemotherapeutic agent,41, 363–368.
Browne M.K., Leslie G.B., Pfirrmann R.W., Brodhage H. (1977): Surg. Gynecol. Obstet., The in vitro and in vivo activity of Taurolin against anaerobic pathogenic organisms,145 (6), 842–846.
Pfirrmann R.W., Leslie C.B. (1979): J. Appl. Bacteriol., The antiendotoxin activity of Taurolin in experimental animals,46 (1), 97–102.
Myers E., Allwood M.C., Gidley M.J., Sanders J.K.M. (1980): J. Appl. Bacteriol., The relationship between structure and activity of Taurolin,48 (1), 89–96.
Wicki O., Pfirrmann R.W. (1979): Caius Burri/Axel Rüter Verlag Hans Huber Bern., Taurolin bei Peritonitis. Aktuelle Probleme in chirurgie und Orthopädie.,12, 42–48.
Erb F., Febvay N., Imbenotte M. (1982): Talanta, Structural investigation of a new organic antiseptic: Taurolidine. Spectroscopic study of its stability and equilibria in various solvents,29, 953–958.
Knight B.I., Skellern G.G., Browne M.K., Pfirrmann R.W., (1981): Br. J. Clin. Pharmac. The characterization and quantitation by High Performance Liquid Chromatography of the metabolites of Taurolin12, 439–440.
Lowry S.R., Huppier D.A. (1981): Anal. Chem., Infrared spectral search system for Gas Chromatography/Fourier Transform Infrared spectrometry,53, 889–893.
Tipson, Parker ( 1971): Applications of IR spectroscopy in biochemistry, biology and médecine. Hilger A.
Garrigou-Lagrange C. (1978): Can. J. Chem., Analyse des spectres de vibration de la β-alanine, de la taurine et de la ciliatine-β56, 663–669.
Vankemmel M., Scherpereel P., Pfirrmann R.W. (1978): Nouv. Pr. Med., Infections bilio-pancréatiques sévères: utilisations isolées per et post-opératoire d’un antiseptique par voie locale et générale,7 (46), 4229.
Vankemmel M., Scherpereel P., Pfirrmann R.W. (1978): Ann. Anesth. France, Irrigation-lavage focalisée et utilisation séquentielle d’un nouvel antiseptique parvoies locale et générale, 11–12.
Vankemmel M., Scherpereel P., Pfirrmann R.W., Duquesnoy O., (1979): Méd. Int., Traitement anti-infectieux local et général par utilisation d’un nouvel antiseptique en chirurgie bilio-pancréatique,14, 683.
Dormard Y. (1980): Propriétés physicochimiques de la Taurolidine en solution. Pharmacocinétique et mécanisme d’action, 21 Mai. Internai Report.
Maillet D. (1980): Une nouvelle chimiothérapie antiinfectieuse, Thèse de Doctorat en Médecine, Lille.
Knight B.I., Skellern G.G., Browne M.K., Pfirrmann R.W. (1980): Intra-peritoneal instillation of Taurolin in peritonitis. Poster session at the World Conference on Clinical Pharmacology and Therapeutics. London, August 3–9 th.
Knight B.I., Skellern G.G., Browne M.K., Pfirrmann R.W. (1981): Br. J. Clin. Pharmac., Peritoneal absorption of the antibacterial and antiendotoxin Taurolin in peritonitis,12, 695–699.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Erb, F., Imbenotte, M., Huvenne, J.P. et al. Structural investigation of a new organic antiseptic: Taurolidine. European Journal of Drug Metabolism and Pharmacokinetics 8, 163–173 (1983). https://doi.org/10.1007/BF03188742
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF03188742