Skip to main content
Log in

The role of Gallium-67 imaging in the detection of foci in recent cases of fever of unknown origin

  • Case Report
  • Published:
Annals of Nuclear Medicine Aims and scope Submit manuscript

Abstract

We have assembled data from patients with fever of unknown origin who underwent gallium scintigraphy during the past 5 years in order to obtain a more current sampling of patients, and evaluated the role of gallium scintigraphy retrospectively. Of the 36 patients studied, gallium scintigraphy was positive and contributed to the detection of the foci or fever origins in 17 (47.2%). The ratio of neoplastic diseases with myeloproliferative and with lymphoproliferative disorders was relatively high compared with previous reports. However, gallium scintigraphy did not contribute to the diagnosis of collagen disease. With the ability to detect both inflammatory and neoplastic lesions, gallium scintigraphy was useful in detecting the foci of fevers of unknown origin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. McNeil BJ, Sanders R, Alderson PO, et al: A prospective study of computed tomography, ultrasound, and gallium imaging in patients with fever.Radiology 139: 647–653, 1981

    PubMed  CAS  Google Scholar 

  2. Lavender JP, Lowe J, Barker JR, et al: Gallium citrate scanning in neoplastic and inflammatory lesions.Br J Radial 44: 361–366, 1971

    Article  CAS  Google Scholar 

  3. Teates CD, Hunter JG: Gallium scanning as a screening test for inflammatory lesions.Radiology 116: 383–387, 1975

    PubMed  CAS  Google Scholar 

  4. Misaki T, Dokoh S, Yagi K, et al: Clinical pathologic conference: Gallium-67-citrate imaging in detection of focal lesions for anemia, proteinuria and prolonged fever.J Nucl Med 31: 512–515, 1990

    PubMed  CAS  Google Scholar 

  5. Nakamura R, Nagamati S, Hoshi H, et al:67Gacitrate scintigraphy in patients with fever of unknown origin.Jpn J Nucl Med 27: 221–226, 1990

    CAS  Google Scholar 

  6. Jacoby GA, Swartz MN: Fever of unknown origin.N Eng J Med 289: 1407–1410, 1973

    Article  CAS  Google Scholar 

  7. Larson EB, Featherstone HJ, Petersdorf RG: Fever of undetermined origin; Diagnosis and follow up of 105 cases, 1970–1980.Medicine 61: 269–292, 1982

    Article  PubMed  CAS  Google Scholar 

  8. Misaki T, Matsui A, Tanaka T, et al: Fever of unknown origin; Re-evaluation of67Ga scintigraphy in detecting causes of fever.Nippon Acta Radiol 50: 655–660, 1990

    PubMed  CAS  Google Scholar 

  9. Tsan MF: Mechanism of gallium-67 accumulation in inflammatory lesions.J Nucl Med 26: 88–92, 1985

    PubMed  CAS  Google Scholar 

  10. Tran MF, Scheffel V: Mechanism of gallium-67 accumulation in tumors.J Nucl Med 27: 1215–1219, 1986

    Google Scholar 

  11. Tzen KY, Oster ZH, Wabner HN, et al: Role of iron-binding proteins and enhanced capillary permeability on the accumulation of gallium-67.J Nucl Med 21: 31–35, 1980

    PubMed  CAS  Google Scholar 

  12. Ohkubo Y, Araki S, Abe K, et al: The effect of FeCl3 on the accumulation of gallium-67 into inflammatory and normal tissues.Annal Nucl Med 2: 59–62, 1988

    Article  CAS  Google Scholar 

  13. Vallabhajosula SR, Harwing JF, Wolf W: Effect of PH on tumor cell uptake of radiogalliumin vitro andin vivo.Eur J Nucl Med 7: 462–468, 1982

    Article  PubMed  CAS  Google Scholar 

  14. Houcar K, Langdon RM, Armitage JO, et al: Myelodysplastic syndrome, a clinical and pathologic analysis of 109 cases.Cancer 56: 553–561, 1985

    Article  Google Scholar 

  15. Milder MS: Tumors of reticuloendothelial and hematopoietic systems. In; Johnston GB, Jones AE, eds. Atlas of gallium-67 scintigraphy. New York; Plenum Press; 1973, 73–118

    Google Scholar 

  16. Kaplan HS: Essentials of staging and management of malignant lymphoma.Sem Roentgenol 15: 219–226, 1980

    Article  CAS  Google Scholar 

  17. Rubinson HA, Isikff MB, Hill MC: Diagnostic imaging of hepatic abscess.Am J Roentgenol 135: 735–740, 1980

    CAS  Google Scholar 

  18. Caffe HH, Watts G, Menal: Gallium-67 citrate scanning in the diagnosis of intra-abdominal abscess.Am J Surg 133: 665–671, 1977

    Article  Google Scholar 

  19. LaManna MT, Saluk PH, Zekavat PP, et al: Gallium localization in peritonitis—two case reports—.J Nucl Med 9: 25–27, 1984

    CAS  Google Scholar 

  20. Perez J, Rivera JV, Bermudez RH: Peritoneal localization of gallium-67.Radiology 123: 695, 1977

    PubMed  CAS  Google Scholar 

  21. Steinbach JJ: Abnormal67Ga-citrate scan of the abdomen in tuberculous peritonitis; Case report.J Nucl Med 17: 272–273, 1976

    PubMed  CAS  Google Scholar 

  22. Siemsen JK, Grebe SF, Waxman D: The use of gallium-67 in pulmonary disorders.Sem Nucl Med 8: 235–249, 1978

    Article  CAS  Google Scholar 

  23. Cox F, Hughes WT: Gallium 67 scanning for the diagnosis of infection in children.Am J Dis Child 133: 1171–1173, 1979

    PubMed  CAS  Google Scholar 

  24. Hiraki Y, Okazaki Y, Murakami K, et al: Wholebody67Ga scintigraphy in dermatomyositis.Jpn J Nucl Med 24: 1483–1489, 1987

    CAS  Google Scholar 

  25. Froelich JW, Swanson D: Imaging of inflammatory process with labeled cells.Semi Nucl Med 14: 128–140, 1984

    Article  CAS  Google Scholar 

  26. Bitar RA, Scheffel U, Murphy PA, et al: Accumulation of Indium-111-labelled neutrophils and gallium- 67 citrate in rabbit abscess.J Nucl Med 27: 1883–1889, 1986

    PubMed  CAS  Google Scholar 

  27. Saito T, Ito K: The clinical comparison between111In labeled leukocyte and67Ga scintigraphy in acute and chronic inflammatory diseases.Jpn J Nucl Med 26: 1303–1310, 1989

    Google Scholar 

  28. Mortelmans L, Malbrain S, Stuyck C, et al:In vitro andin vivo evaluation of granulocyte labeling with99mTc-d-1-HM-PAO.J Nucl Med 30: 2022–2028, 1989

    PubMed  CAS  Google Scholar 

  29. Thakur ML, DeFulvio J, Park CH, et al: Evaluation of Tc-99m labeled proteins for localization of inflammation: comparison with I-125-TNT-1 and Ga-67 citrate.J Nucl Med 31: 810, 1990

    Google Scholar 

  30. Schauwecker DS, Carlson KA, Kalasinski LA: Comparison of In-111 nonspecific polyclonal IgG with In-111 leukocytes (WBC) in a canine osteomyelitis model.J Nucl Med 31: 811, 1990

    Google Scholar 

  31. Buscombe, JR, Lui D, Ell PJ: First study on the efficiency of Tc-99m-HIG as a new agent for the investigation of infection and inflammation.J Nucl Med 31: 811, 1990

    Google Scholar 

  32. Sfakianakis GN, Al-Sheikh W, Heal A, et al: Comparison of scintigraphy with In-111 leukocytes and Ga-67 in the diagnosis of occult sepsis.J Nucl Med 23: 618–626, 1982

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Suga, K., Nakagi, K., Kuramitsu, T. et al. The role of Gallium-67 imaging in the detection of foci in recent cases of fever of unknown origin. Ann Nucl Med 5, 35–40 (1991). https://doi.org/10.1007/BF03164611

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03164611

Key words

Navigation