Abstract
Basic events concerning oxidative phosphorylation, i.e. the synthesis of ATP at the expense of respired oxygen at the level of mitochondria are described. Our knowledge concerning the functioning of respiratory chain, its structure, organization and topology inside the inner membrane of mitochondria has considerably improved in recent years. A central question — how does the respiratory chain cooperate with ATP-synthetase, also embedded in the inner membrane, to bring about the oxidative phosphorylation of ADP to ATP — has been one of the most challenging and difficult problems in biochemical research. The chemiosmotic hypothesis proposed by the British biochemist Peter Mitchell appears best in describing the basic events of the recovery of the redox energy liberated along the respiratory chain to synthesize ATP through a membrane process. Moreover the chemiosmotic hypothesis is not restricted to mitochondrial oxidative phosphorylation but appears to provide a general explanation to the synthesis of ATP in all transducing membranes: inner mitochondrial membrane, bacterial plasma membrane, thylakoid membranes in chloroplasts of green plants.
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References
Belitzer, V. A. and Tsibakova, E. T. The mechanism of phosphorylation associated with respiration.Biokimiia 4 (1939) 516–526
Capaldi, R. A. Arrangement of proteins in the mitochondrial inner membrane.Biochim. Biophys. Acta 694 (1982) 291–306
Chance, B. and Williams, G. R. The respiratory chain and oxidative phosphorylation.Adv. Enzymol. 17 (1956) 65–134
Hatefi, Y. The enzymes and the enzyme complexes of the mitochondrial oxidative phosphorylation system. In Martonosi, A. (ed.)The Enzymes of Biological Membranes, Plenum Press, New York, 1976, Vol. 4, pp. 3–41
Keilin, D.The History of Cell Respiration and Cytochromes, Cambridge University Press, London, 1966
Krebs, H. A. and Johnson, W. A. The role of citric acid in intermediary metabolism in animal tissue.Enzymologia 4 (1937) 148
Mitchell, P. Coupling of phosphorylation to electron and hydrogen transfer by a chemiosmotic type of mechanism.Nature (London) 191 (1961) 105
Mitchell, P. Keilin’s respiratory chain concept and its chemiosmotic consequences. Nobel Lecture.Science 206 (1979) 1148–1159
Racker, E.A New Look at Mechanisms in Bioenergetics, Academic Press, New York, 1976.
Books and General Reviews
Boyer, P. D., Chance, B., Ernster, L., Mitchell, P., Racker, E. and Slater, E. C. Oxidative phosphorylation and photo-phosphorylation.Ann. Rev. Biochem. 46 (1977) 955–1026
Lehninger, A. L.The Mitochondrion: Molecular Basis of Structure and Function, Benjamin, 1965, New York
Lehninger, A. L. Mitochondria and biological mineralization processes: an exploration. In E. Quagliariello, F. Palmieri and T. Singer, eds.Horizons in Biochemistry and Biophysics, vol. 4 (1977) pp. 1–30, Addison-Wesley, Reading, Mass
Tzagoloff, A.Mitochondria, 1982, Plenum Press, New York.
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Gautheron, D.C. Mitochondrial oxidative phosphorylation and respiratory chain: Review. J. Inher. Metab. Dis. 7 (Suppl 1), 57–61 (1984). https://doi.org/10.1007/BF03047376
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DOI: https://doi.org/10.1007/BF03047376