Abstract
To test the hypothesis that the initial distribution volume of glucose (IDVG) reflects plasma volume, the relationship between the IDVG and indocyanine green (ICG) assessments of plasma volume (Vd-ICG) were evaluated simultaneously both before and after induced haemorrhage (30 ml· kg−1) in eight mongrel dogs. The IDVG and the Vd-ICG were calculated with a onecompartment model from repeated measurements of plasma glucose three to seven minutes, and of plasma ICG three to nine minutes after simultaneous infusions of both glucose 100 mg· kg−1 and ICG 0.5 mg· kg−1. The IDVG calculated with a onecompartment model (IDVG-OCM) was also compared with a twocompartment model within 15 min (IDVG-TCM) on nine occasions among a total of 12 determinations. Using Bland and Altman analysis to compare the two analytical models, the IDVG-OCM tends to overestimate the IDVG-TCM by an average of 0.04 L. Although the IDVGOCM was two to three times larger than the Vd-ICG at each corresponding point, a correlation was obtained between the IDVG-OCM and the Vd-ICG before and after induced haemorrhage (r = 0.85, n = 16, P < 0.001). We conclude that the IDVG reflects plasma volume in normal and hypovolaemic dogs, although the IDVG cannot be used directly to estimate plasma volume.
Résumé
Pour vérifier l’hypothèse selon laquelle la distribution initiale du volume de glucose (IDVG) réflète le volume plasmatique, la relation entre l’IDVG et l’épreuve de détermination du volume plasmatique (Vd-ICG) par le vert d’indocyanine (ICG) est évaluée simultanément avant et après l’hémorragie (30 ml· kg−1) provoquée chez huit chiens de race commune. L’IDVG et le Vd-ICG sont calculés sur un modèle à compartiment unique à partir de dosages répétés du glucose plasmatique de trois à sept min, et de l’ICG plasmatique de trois à neuf min, après des perfusions simultanées de glucose 100 mg· kg−1 et de VIC 0,5 mg · kg−1. L’IDVG calculée sur un modèle à compartiment unique (IDVG-OCM) a aussi été comparée en deçà de 15 min à un modèle à deux compartiments (IDVG-TCM) à neuf occasions parmi un total de 12 déterminations. Avec l’analyse de Bland et Altman pour comparer les deux modèles analytiques, l’IDVG-OCM a une tendance à surestimer l’IDVG-TCM par 0,04 L en moyenne. Bien que l’IDVG-OCM soit de deux à trois fois plus considerable que le Vd-ICG à chacun des point correspondants, une corrélation est obtenue entre l’IDVG-OCM et le Vd-ICG avant et après l’hémorragie provoquée (r = 0,85, n = 16, P < 0.001). Nous concluons que l’IDVG reflète le volume plasmatique chez les chiens normaux et les chiens hypovolémiques, bien que l’IDVG ne mesure pas directement le volume plasmatique.
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Koh, H., Ishihara, H., Miyahara, A. et al. Does the initial distribution volume of glucose reflect plasma volume after haemorrhage in dogs?. Can J Anaesth 42, 163–167 (1995). https://doi.org/10.1007/BF03028271
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DOI: https://doi.org/10.1007/BF03028271