Article PDF
References
Todd MM, Warner DS. A comfortable hypothesis reevaluated. Cerebral metabolic depression and brain protection during ischemia (Editorial). Anesthesiology 1992; 76: 161–4.
Bain JA, Catton DV, Cox JMR, Spoerel WE. The effect of general anaesthesia on the tolerance of cerebral ischaemia in rabbits. Can Anaes Soc J 1967; 14: 69–78.
Warner DS, McFarlane C, Todd MM, Ludwig P, McAllister AM. Sevoflurane and halothane reduce focal ischemic brain damage in the rat. Possible influence on thermoregulation. Anesthesiology 1993; 79: 985–92.
Warner DS, Ludwig PS, Pearlstein R, Brinkhous AD. Halothane reduces focal ischemic injury in the rat when brain temperature is controlled. Anesthesiology 1995; 82: 1237–45.
Soonthon-Brant V, Patel PM, Drummond JC, Cole DJ, Kelly PJ, Watson M. Fentanyl does not increase brain injury after focal cerebral ischemia in rats. Anesth Analg 1999; 88: 49–55.
Cechetto DF, Gelb AW. Propofol sedation compared to awake reduces cerebral infarct size in rats. Anesth Analg 1999; 88: S1–424 (abstract).
Gelb AW, Floyd P, Lok P, Peerless SJ, Farrell M. A prophylactic bolus of thiopentone does not protect against prolonged focal cerebral ischaemia. Can Anaesth Soc J 1986; 33: 173–7.
Roach GW, Newman MF, Murkin JM, et al. Ineffectiveness of burst suppression therapy in mitigating perioperative cerebrovascular dysfunction. Anesthesiology 1999; 90: 1255–64.
Nussmeier NA, Arlund C, Slogoff S. Neuropsychiatric complications after cardiopulmonary bypass: cerebral protection by a barbiturate. Anesthesiology 1986; 64: 165–70.
Xiong L, Zhu Z, Dong H, et al. Isoflurane preconditioning induces neuroprotection against middle cerebral artery occlusion damage in the rat. Chin J Anesthesiol 2000; 20: 730–2.
Warner DS, Takaoka S, Wu B, et al. Electroencephalographic burst suppression is not required to elicit maximal neuroprotection from pentobarbital in a rat model of focal cerebral ischemia. Anesthesiology 1996; 84: 1475–84.
Kawaguchi M, Kimbro JR, Drummond JC, Cole DJ, Kelly PJ, Patel PM. Isoflurane delays but does not prevent cerebral infarction in rats subjected to focal ischemia. Anesthesiology 2000; 92: 1335–42.
Shuaib A, Murabit MA, Kanthan R, Howlett W, Wishart T. The neuroprotective effects of gamma-vinyl GABA in transient global ischemia: a morphological study with early and delayed evaluations. Neurosci Lett 1996; 204: 1–4.
Wilson JX, Gelb AW. Free radicals, antioxidants and neurologic injury: possible relationship to cerebral protection by anesthetics. J neurosurg anesthesiol (in press).
Cole DJ, Cross LM, Drummond JC, Patel PM, Jacobsen WK. Thiopentone and methohexital, but not pentobarbitone, reduce early focal cerebral ischemic injury in rats. Can J Anesth 2001; 48: 807–14.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Gelb, A.W., Wilson, J.X. & Cechetto, D.F. Anesthetics and cerebral ischemia — should we continue to dream the impossible dream?. Can J Anesth 48, 727–731 (2001). https://doi.org/10.1007/BF03016685
Issue Date:
DOI: https://doi.org/10.1007/BF03016685