Abstract
Purpose
A high incidence of postoperative nausea and vomiting (PONV) has been noted in patients with a history of postoperative emesis. This study was undertaken to compare the efficacy of granisetron, droperidol and metoclopramide, in the prevention of PONV in such patients undergoing general anaesthesia for major gynaecological surgery.
Methods
In a randomised, double-blind study, 90 female patients received 2.5 mg granisetron, 1.25 mg droperidol or 10 mg metoclopramide (n = 30 of each)iv immediately before induction of anaesthesia. The same standard general anaesthetic technique, which consisted of isoflurane in nitrous oxide and oxygen, was used. Nausea, vomiting and safety assessments were performed continuously during the first 24 hr after anaesthesia.
Results
The incidence of PONV was 20% with granisetron, 57% with droperidol and 60% with metoclopramide (P < 0.05; overall Fisher’s exact probability test). No clinically adverse events were observed in any group.
Conclusion
Granisetron is more effective than droperidol or metoclopramide in preventing PONV in female patients with a history of postoperative emesis.
Résumé
Objectif
Les patientes présentant une histoire de vomissements post opératoires ont une incidence élevée de nausées/vomissements post opératoires (NVPO). Le but de cette étude est de comparer l’efficacité du granisétron, du dropéridol et du métoclopramide en prévention des NVPO chez de tels patientes soumises à une anesthésie générale pour chirurgie gynécologique majeure.
Méthodes
Dans une étude aléatoire et à double insu, 90 patientes ont reçu par voie I.V 2,5 mg de granisétron, 1,25 mg de dropéridol ou 10 mg de métoclopramide (n = 30 chaque groupe) immédiatement avant l’induction de l’anesthésie. La technique d’anesthésie générale consistait en isoflurane, N2O,O2 et était la même pour toutes les patientes. Lévaluation des nausée/vomissements et la surveillance ont été réalisées de façon continue durant le premier 24 heures.
Résultats
L’incidence des NVPO étart de 20% avec le granisétron, 57% avec le dropéridol et 60% avec le métoclopramide (P < 0,05 test de Fisher exact). Aucun effet secondaire indésirable n’a été observé dans les trois groupes.
Conclusion
Le granisétron est plus efficace que le droperidol ou le métoclopramide dans la prévention des NVPO chez des patientes avec histoire de vomissements post opératoires.
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References
Watcha MF, White PF. Postoperative nausea and vomiting. Its etiology, treatment, and prevention. Anesthesiology 1992; 77: 162–84.
Purkis IE. Factors that influence postoperative vomiting. Can Anaesth Soc J 1964; 11: 335–53.
Fujii Y, Tanaka H, Toyooka H. Prophylactic antiemetic efficacy of granisetron in patients with and without previous postoperative emesis. Can J Anaesth 1997; 44: 273–7.
Bertnudez J, Boyle EA, Miner WD, Sanger GJ. The antiemetic potential of the 5-hydroxytryptamine3 receptor antagonist BRL 43694. Br J Cancer 1988; 58: 644–50.
Fujii T, Tanaka H, Toyooka H. Reduction of postoperative nausea and vomiting with granisetron. Can J Anaesth 1994; 41: 291–4.
Fujii Y, Tanaka H, Toyooka H. Optimal anti-emetic dose of granisetron for preventing postoperative nausea and vomiting. Can J Anaesth 1994; 41: 794–7.
Carmichael J, Cantwell BMJ, Edwards CM, et al. A pharmacokinetic study of granisetron (BRL 43694A), a selective 5-HT3 receptor antagonist: correlation with anti-emetic response. Cancer Chemother Pharmacol 1989; 24: 45–9.
Furue H, Oota K, Tagguchi T, Niitani H. Clinical evaluation of granisetron against nausea and vomiting induced by anticancer drugs (I). Optimal dose-finding study (Japanese). J Clin Ther Med 1990; 6(Suppl): 49–61.
Yarker YE, McTavish D. Granisetron. An update of its therapeutic use in nausea and vomiting induced by antineoplastic therapy. Drugs 1994; 48: 761–93.
Korttila K, Kauste A, Auvinen J. Comparison of domperidone, droperidol, and metoclopramide in the prevention and treatment of nausea and vomiting after balanced general anesthesia. Anesth Analg 1979; 58: 396–400.
Cohen SE, Woods WA, Wyner J. Antiemetic efficacy of droperidol and metoclopramide. Anesthesiology 1984; 60: 67–9.
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Additional information
A retraction note to this article is available at http://dx.doi.org/10.1007/s12630-013-9961-3.
This article has been retracted due to two reasons: Many variables reported in the studies are exceedingly unlikely. The author's institution is not able to attest to the integrity of the study and/or the data conducted under its auspices.
An erratum to this article is available at http://dx.doi.org/10.1007/s12630-013-9961-3.
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Fujii, Y., Saitoh, Y., Tanaka, H. et al. RETRACTED ARTICLE: Prevention of PONV with granisetron, droperidol or metoclopramide in patients with postoperative emesis. Can J Anesth/J Can Anesth 45, 153–156 (1998). https://doi.org/10.1007/BF03013255
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DOI: https://doi.org/10.1007/BF03013255