Abstract
Loading and maintenance infusions of morphine sulfate were administered to 5 young male patients 23-34-yr-old prior to elective surgery. Apparent steady-state plasma concentrations were achieved 30 minutes after the start of the drug infusion. The volume of distribution at steady-state (2.43 ± .48 L.kg-1)beta elimination rate constant (0.700 ± 0.162/h) and plasma clearance (1.66 ± 0.33 L.kg-1.h-1) were similar to values previously determined in young healthy subjects receiving a single bolus infusion. These data confirm our findings concerning morphine disposition in healthy young subjects and demonstrate the feasibility of achieving predictable plasma concentrations of morphine for future assessment of pharmacodynamiclpharmacokinetic relationships for this drug.
Résumé
Avant la chirurgie élective des perfusions de sulfate de morphine ont été administrés à cinq jeunes patients âgés de 23 à 34 ans. Les concentrations plasmatiques stables ont été acquises 30 minutes après le debut de la perfusion. Le volume de distribution (2.43 ± 0.48 L.kg-1), la constante bita du taux a élimination (0.700 ± 0.162/h) et la clearance plasmatique (1.66 ± 0.33 L.kg-1.h-1) étaient similaires à des valeurs déterminées au préalable chez les jeunes sujets en bonne santé recevant un bolus unique. Ces données confirment nos résultats concernant la disposition de la morphine chez les jeunes sujets sains et démontrent la possibilité d’acquerir des concentrations plasmatiques prévisibles de morphine afin d’évaluer dans le futur la relation phamacokinétiquelphamaco-dynamique de cet agent.
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This study was supported by grants from The Canadian Foundation for the Advancement of Clinical Pharmacology and the Manitoba Heart Foundation. Dr. Owen received a post-doctoral fellowship from the Medical Research Council of Canada.
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Sitar, D.S., Duke, P.C., Owen, J.A. et al. Kinetic disposition of morphine in young males after intravenous loading and maintenance infusions. Can Anaesth Soc J 33, 145–149 (1986). https://doi.org/10.1007/BF03010823
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DOI: https://doi.org/10.1007/BF03010823