Abstract
To determine whether intravenous atropine and glycopyrrolate are equally effective in preventing succinyl-choline-induced heart rate changes, we studied the heart rate during the first 78 seconds of anaesthesia in 40 children anaesthetized with either thiopemone, atropine (0.02mgkg~’jandsuccinylcholine(2 mg.kg-1), orthio-pentone, glycopyrrolate (0.01 mg.kg-1) and succinylcholine (2 mg.kg-1 ). Each treatment group was divided into four subgroups which differed only in the interval (6, 10, 15, 20 seconds) between injection of atropine or glycopyrrolate and succinylcholine.
During the 54 seconds after succinylcholine, the mean heart rate of each subgroup decreased transiently and then returned to the pre-induclion heart rate or higher. There was no difference in either the magnitude or the duration of the decrease in heart rate or the subsequent increase in heart rate between respective subgroups. Bradycardia occurred in only two patients, both of whom received glycopyrrolate.
We conclude that atropine (0.02 mg.kg-1) and glycopyrrolate (0.01 mg.kg-1) are equally effective in attenuating succinylcholine-induced changes in heart rate in children.
Résumé
Dans le but de comparer l’efficacité de l’atropine el de glycopyrrolate injectés par la voie veineuse pour la prévention des changements de fréquence cardiaque causés par la succinylcholine, nous avons étudié la fréquence cardiaque pendant les premières 78 secondes d’anesthésie chez 40 enfants anesthésiés avec l’une ou l’autre des deux associations médicamenteuses suivantes: Ihiopental, atropine (0.02 mg.kg-1) et succinylcholine (2 mg.kg-1), ou ihiopental, glycopyrrolate (0.01 mg. kg-1) et succinylcholine (2 mg.kg-1). Chaque groupe a été divisé en quatre sous-groupes différant seulement par l’intervalle (6, 10, 15 et 20 secondes) séparant l’injection de l’atropine ou du glycopyrrolate et de la succinylcholine.
Pendant les 54 secondes suivant l’injection de succinylcholine, lafréquence cardiaque moyenne de chaque sous-groupe a baissé transitoirement et est revenue à son niveau d’avant l’induction ou à un niveau plus élevé. Il n’y a pas eu de différence dans l’importance ou la durée du ralentissement cardiaque ou de l’accélération subséquente entre les sous-groupes respectifs. Les deux seuts patients braaycardes avaient reçu du glycopyrrolate. Nous concluons que l’atropine (0.02 mg.kg-1) el le glycopyrrolate (0.01 mg.kg-1) sont également efficaces pour atténuer chez l’enfant l’importance des changements de fréquence cardiaque causés par ta succinylcholine
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Lerrman, J., Chinyanga, H.M. The heart rate response to succinyl-choline in children: A comparison of atropine and glycopyrrolate. Can Anaesth Soc J 30, 377–381 (1983). https://doi.org/10.1007/BF03007860
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DOI: https://doi.org/10.1007/BF03007860