Summary
The use of intravenous procaine in the treatment of hyperpyrexia in a patient with hyperparathyroidism has not been previously reported. A case of metastatic malignant melanoma precipitating the syndrome of hypertonicity of muscle, hyperpyrexia, acidemia, hypercalcemia and elevated serum parathormone levels is presented.
Mithramycin was used in an attempt to reduce elevated serum calcium concentrations. The use of intravenous procaine in “caffeine rigor” and malignant hyper-thermia due to succinylcholine and halothane formed the basis for its trial in this case.
The relationship between cyclic AMP and calcium ions is discussed in postulating a mechanism of procaine action.
Résumé
Le mélanome malin métastatique de la glande parathyroïde n’a pas été antérieurement rapporté. Un cas de mélanome malin métastatique précipitant le syndrome d’hypertonicité musculaire avec hyperthermie, acidémie, hypercalcémie et élévation de la parathormone sérique est présenté. L’emploi de procaine intraveineuse dans le “caffeine rigor” et dans l’hyperthermie maligne due à la succinylcholine et à l’halothane explique son utilisation dans ce cas d’hyperthyroïdisme. La mithramycine a été utilisée dans le but de réduire les concentrations sériques élevées de calcium.
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Borden, H., Hummer, G.J., Landon, C.W. et al. The use of procaine in acquired malignant hyperthermia in a patient with malignant melanoma metastatic to the parathyroid gland: A case report. Canad. Anaesth. Soc. J. 23, 616–623 (1976). https://doi.org/10.1007/BF03006744
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DOI: https://doi.org/10.1007/BF03006744