Summary
Malignant hyperthermia is a genetically inherited condition in many cases. The pattern of inheritance appears to be that of autosomal dominance with reduced penetrance and variable expressivity. The condition is not manifested in infancy or old age. The possible association with musculo-skeletal disease requires further investigation, although a large family tree did not support previously collected evidence in favour of this association.
Résumé
Souvent l’hyperthermie maligne est héréditaire. Le mode de transmission semble être à prédominance autosomique avec infiltration limitée et des manifestations variables. Cette condition ne se manifeste pas dans l’enfance ni dans la vieillesse. Pour l’associer à line maladie musculosquelettique, il faudrait de plus amples renseignements; cependant une étude généalogique importante n’a pas confirmé des preuves préalablement recueillies en faveur de cette association.
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Britt, B.A., Locher, W.G. & Kalow, W. Hereditary aspects of malignant hyperthermia. Can. Anaes. Soc. J. 16, 89–98 (1969). https://doi.org/10.1007/BF03005788
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DOI: https://doi.org/10.1007/BF03005788