Abstract
This review focuses on the pathophysiology of the Factor VIII molecule as it relates to Von Willebrand’s disease. Three major categories of Von Willebrand’ s disease are identified. The perioperative diagnosis and management of all categories are reviewed. 1-Deamino-8-D-argnine vasopressin (DDAVP) is presented as an alternative to the transfusion of blood and blood products for the management of a bleeding diathesis.
Résumé
Cette revue met l’emphase sur la pathophysiologie du facteur VIII relié à la maladie de Von Willebrand. Trois catégories majeures de la maladie de Von Willebrand sont identifiées. Le diagnostic périopératoire et la conduite face à ces trois catégories sont revus. Le 1-deamino-8-D-arginine vasopressine (DDAVP) est présenté comme une alternative à la transfusion sanguine et les dérivés du sang pour la conduite lors d’une diathèse hémorragique.
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Cameron, C.B., Kobrinsky, N. Perioperative management of patients with von Willebrand’s disease. Can J Anaesth 37, 341–347 (1990). https://doi.org/10.1007/BF03005587
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DOI: https://doi.org/10.1007/BF03005587