Summary
The ventilatory responses mediated by the central and peripheral chemoreceptors were separately assessed in eight healthy volunteers before and after the oral ingestion of ethanol in a dose of 0.75 ml/kg. No significant depression of the central response was observed, but a significant depression of the peripheral response was observed at 25 and 95 minutes after the consumption of ethanol. The peripheral chemoreceptor stimulus was the simultaneous increase of hypoxia and hypercapnia and this novel method is described.
Résumé
La réponse respiratoire réflexe initiée par les chémorécepteurs centraux et périphériques a été étudiée de façon séparée chez huit volontaires en bonne santé, avant et après ingestion orale de 0.75 ml/kilo ďalcool éthylique.
On n’a pas observé de dépression significative du mécanisme central, mais une dépression significative de la réponse périphérique a été observée, 25 et 95 minutes après ingestion de ľalcool.
Comme stimulus des chémorécepteurs périphériques, on a utilisé une hypoxie et une hypercapnie simultanée et croissante. Cette nouvelle méthode est décrite.
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Duffin, J., Jacobson, E.R. & Orsini, E.C. The effect of ethanol on the ventilatory responses mediated by the peripheral chemoreceptors in man. Can. Anaesth. Soc. J. 25, 181–190 (1978). https://doi.org/10.1007/BF03004877
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DOI: https://doi.org/10.1007/BF03004877