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The incidence and permanence of unexplained gastric anacidity in the rhesus monkey after histamine and mecholyl, with hemotologic studies

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The American Journal of Digestive Diseases

Conclusions

1. The incidence of gastric anacidity after histamine in a series of 45 healthy Rhesus monkeys was 17.7% and was higher in the female (22.2%) than in the male (13.0%).

2. Gastric pepsin and rennin was present in the gastric contents of all of the anacid monkeys.

3. The unexplained gastric anacidity after histamine lasted for from two to five months and disappeared suddenly following administration of mecholyl.

4. Subcutaneous injections of mecholyl caused the secretion of free acid in normal monkeys and in eight monkeys which have been anacid to histamine for five months.

5. Hematologic studies revealed no age or sex difference in the blood picture of our monkeys.

6. These observations in monkeys indicate that the effects of mecholyl in anacid human subjects should be studied.

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References

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Authors and Affiliations

  1. Chicago, Illinois

    J. G. Schnedorf M.S., M.B. & A. C. Ivy Ph.D., M.D.

Authors
  1. J. G. Schnedorf M.S., M.B.
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  2. A. C. Ivy Ph.D., M.D.
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Additional information

From the Department of Physiology and Pharmacology, Northwestern University Medical School, Chicago, Ill.

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Schnedorf, J.G., Ivy, A.C. The incidence and permanence of unexplained gastric anacidity in the rhesus monkey after histamine and mecholyl, with hemotologic studies. American Journal of Digestive Diseases and Nutrition 4, 429–432 (1937). https://doi.org/10.1007/BF02999951

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  • DOI: https://doi.org/10.1007/BF02999951

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