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Abnormal accumulation of [18F]fluorodeoxyglucose in the aortic wall related to inflammatory changes: Three case reports

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Abstract

We present 3 cases with abnormal accumulation of FDG in the aortic wall. Their clinical manifestations were vague or asymptomatic, and laboratory data were consistent with inflammatory reaction. These 3 patients were diagnosed with Takayasu arteritis, inflammatory aortic aneurysm (IAA), and retroperitoneal fibrosis (RF), respectively. FDG-PET and CT images showed the intense FDG uptake corresponding to the arterial walls and/or the soft tissue density surrounding the artery. It was deduced that FDG was probably taken up by inflammatory cells which infiltrated the arterial walls and/or the soft tissue mass. These cases indicated that FDG-PET is a useful method for localization of inflammatory lesion in patients with unspecific clinical findings and laboratory data.

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References

  1. Tian M, Zhang H, Nakasone Y, Mogi K, Endo K. Expression of Glut-1 and Glut-3 in untreated oral squamous cell carcinoma compared with FDG accumulation in a PET study.Eur J Nucl Med Mol Imaging 2004; 31: 5–12.

    Article  PubMed  CAS  Google Scholar 

  2. Higashi K, Ueda Y, Sakurai A, Wang XM, Xu L, Murakami M, et al. Correlation of Glut-1 glucose transporter expression with.Eur J Nucl Med Mol Imaging 2000; 27: 1778–1785.

    Article  CAS  Google Scholar 

  3. Higashi T, Tamaki N, Torizuka T, Nakamoto Y, Sakahara H, Kimura T, et al. FDG uptake, GLUT-1 glucose transporter and cellularity in human pancreatic tumors.J Nucl Med 1998; 39: 1727–1735.

    PubMed  CAS  Google Scholar 

  4. Higashi T, Tamaki N, Honda T, Torizuka T, Kimura T, Inokuma T, et al. Expression of glucose transporters in human pancreatic tumors compared with increased FDG accumulation in PET study.J Nucl Med 1997; 38: 1337–1344.

    PubMed  CAS  Google Scholar 

  5. Brown RS, Wahl RL. Overexpression of Glut-1 glucose transporter in human breast cancer, an immunohistochemi- cal study.Cancer 1993; 72: 2979–2985.

    Article  PubMed  CAS  Google Scholar 

  6. Bakheet SM, Powe J, Kandil A, Ezzat A, Rostom A, Amartey J. F-18 FDG uptake in breast infection and inflammation.Clin Nucl Med 2000; 25: 100–103.

    Article  PubMed  CAS  Google Scholar 

  7. Shreve PD, Anzai Y, Wahl RL. Pitfalls in oncologic diagnosis with FDG PET imaging: physiologic and benign variants.Radiographics 1999; 19: 61–77.

    PubMed  CAS  Google Scholar 

  8. Bleeker-Rovers CP, de Kleijn EM, Corstens FH, van derMeerJW, Oyen WJ. Clinical value of FDG PET in patients with fever of unknown origin and patients suspected of focal infection or inflammation.Eur J Nucl Med Mol Imaging 2004; 31: 29–37.

    Article  PubMed  Google Scholar 

  9. Zhuang H, Alavi A. 18-fluorodeoxyglucose positron emission tomographic imaging in the detection and monitoring of infection and inflammation.Semin Nucl Med 2002; 32: 47–59.

    Article  PubMed  Google Scholar 

  10. Stumpe KD, Dazzi H, Schaffner A, von Schulthess GK. Infection imaging using whole-body FDG-PET.Eur J Nucl Med Mol Imaging 2000; 27: 822–832.

    Article  CAS  Google Scholar 

  11. Guhlmann A, Brecht-Krauss D, Suger G, Glatting G, Kotzerke J, Kotzerke J. Chronic osteomyelitis: detection with FDG-PET and correlation with histopathologic findings.Radiology 1998; 206: 749–754.

    PubMed  CAS  Google Scholar 

  12. Sugawara Y, Braun DK, Kison, PV, Russo JE, Zasadny KR, Wahl RL. Rapid detection of human infections with fluorine- 18 fluorodeoxyglucose and positron emission tomography: preliminary results.Eur J Nucl Med 1998; 25: 1238–1243.

    Article  PubMed  CAS  Google Scholar 

  13. Ichiya Y, Kuwabara Y, Sasaki M, Yoshida T, Akashi Y, Murayama S, et al. FDG-PET in infectious lesions: The detection and assessment of lesion activity.Ann Nucl Med 1996; 10: 185–191.

    Article  PubMed  CAS  Google Scholar 

  14. Yun M, Yeh D, Araujo LI, Jang S, Newberg A, Alavi A. F-18 FDG uptake in the large arteries: a new observation.Clin Nucl Med 2001; 26: 314–319.

    Article  PubMed  CAS  Google Scholar 

  15. lino M, Kuribayashi S, Imakita S, Takamiya M, Matsuo H, Ookita Y,et al. Sensitivity and specificity of CT in the diagnosis of inflammatory abdominal aortic aneurysms.J Comput Assist Tomogr 2002; 26: 1006–1012.

    Article  Google Scholar 

  16. Mochizuki T, Tsukamoto E, Kuge Y, Kanegae K, Zhao S, Hikosaka K, et al. FDG uptake and glucose transporter subtype expression in experimental tumor and inflammation models.J Nucl Med 2001; 42: 1551–1555.

    PubMed  CAS  Google Scholar 

  17. Johnston SL, Lock RJ, Gompels MM. Takayasu arteritis: a review.J Clin Pathol 2002; 55: 481–486.

    PubMed  CAS  Google Scholar 

  18. Arend WP, Michel BA, Bloch DA, Hunder GG, Calabrese LH, Edworthy SM, et al. The American college of Rheumatology 1990 criteria for the classification of Takayasu arteritis.Arthritis Rheum 1990; 33: 1129–1134.

    Article  PubMed  CAS  Google Scholar 

  19. Vaglio A, Buzio C. Chronic periaortitis: a spectrum of disease.Curr Opin Rheumatol 2005; 17: 34–40.

    Article  PubMed  Google Scholar 

  20. Meller J, Strutz F, Siefker U, Scheel A, Sahlmann CO, Lehmann K, et al. Early diagnosis and follow-up of aortitis with [18F]FDG PET and MRI.Eur J Nucl Med 2003; 30: 730–736.

    CAS  Google Scholar 

  21. Belhocine T, Blockmans D, Hustinz R, Vandevivere J, Mortelmans L. Imaging of large vessel vasculitis with (18)FDG PET: illusion or reality? A critical review of the literature data.Eur J Nucl Med 2003; 30: 1305–1313.

    Article  Google Scholar 

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Takahashi, M., Momose, T., Kameyama, M. et al. Abnormal accumulation of [18F]fluorodeoxyglucose in the aortic wall related to inflammatory changes: Three case reports. Ann Nucl Med 20, 361–364 (2006). https://doi.org/10.1007/BF02987248

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  • DOI: https://doi.org/10.1007/BF02987248

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