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Clinical and Genetic Characteristics of Japanese Burkitt Lymphomas with or without Leukemic Presentation

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Abstract

To clarify the clinical and genetic features of Burkitt lymphoma with or without leukemic presentation, we have conducted clinical, cytogenetic, and genetic studies. Of 40 Japanese patients with Burkitt lymphoma examined by cytogenetic and/or fluorescence in situ hybridization analysis or Southern blot analysis usingMYC probes, 35 patients had t(8;14) translocations, and 5 had t(8;22). Breakpoints were located far upstream ofMYC in 4 (12%) of 33 tumors with t(8;14), and Epstein-Barr virus infection was found in 3 (8%) of 40 tumors. These findings are similar to those reported for non-Japanese patients with the sporadic form of Burkitt lymphoma. Clinical and genetic characteristic were compared for 30 patients presenting with lymphoma and 10 presenting with leukemia. The overall survival was shorter in aggressively treated leukemia patients than in aggressively treated lymphoma patients(P =.003); however, the incidence rates ofTP53 mutation,p16INK4a deletion, andp15INK4b deletion that were found in 6 (15%) of 40,3 (9%) of 35, and 2 (6%) of 35 tumors, respectively, were similar between the 2 subtypes. Thus, the present study has shown the different prognoses for the 2 subtypes of Burkitt lymphoma but has failed to clarify the genetic backgrounds that may explain the different outcomes.Int J Hematol. 2003;77:490-498.

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Authors and Affiliations

  1. Department of Cancer Chemotherapy, Saitama Cancer Center, 818 Komuro, Ina, 362-0806, Saitama, Japan

    Takeshi Namiki, Akiko Sakashita, Hirofumi Kobayashi, Nobuo Maseki, Toshiyuki Izumo & Yasuhiko Kaneko

  2. Department of Pediatrics, Mie University, Mie

    Yoshihiro Komada

  3. Department of Pediatrics, Kanazawa University, Kanazawa

    Shoichi Koizumi

  4. Department of Pediatrics, Kohnan Hospital, Sapporo

    Takaaki Shikano

  5. Department of Pediatrics, Fukushima Medical College, Fukushima

    Atsushi Kikuta

  6. Department of Pediatrics, Akita University, Akita

    Arata Watanabe

  7. Department of Pathology, Fukuoka University, Fukuoka, Japan

    Junji Suzumiya & Masahiro Kikuchi

Authors
  1. Takeshi Namiki
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  2. Akiko Sakashita
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  3. Hirofumi Kobayashi
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  4. Nobuo Maseki
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  11. Junji Suzumiya
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  12. Masahiro Kikuchi
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  13. Yasuhiko Kaneko
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Corresponding author

Correspondence to Yasuhiko Kaneko.

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Namiki, T., Sakashita, A., Kobayashi, H. et al. Clinical and Genetic Characteristics of Japanese Burkitt Lymphomas with or without Leukemic Presentation. Int J Hematol 77, 490–498 (2003). https://doi.org/10.1007/BF02986618

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  • DOI: https://doi.org/10.1007/BF02986618

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