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18F-FDG and11C-methionine PET for evaluation of treatment response of lung cancer after stereotactic radiotherapy

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Abstract

This study was performed to investigate the feasibility of FDG- and L-[methyl-11C]methionine (Met)-PET for the follow up of lung cancer after stereotactic radiotherapy (SRT). Nine patients (pt) with solitary lung cancer underwent SRT. Met- and FDG-PET studies were performed one week before SRT and from one week to 8 months after SRT. Responses to SRT were complete in 2 pt and partial in 7 pt. Met- and FDG-PET scan showed high tracer uptake in all tumors before SRT. After SRT, standardized uptake values (SUV) of FDG and Met changed concordantly. Both decreased with time in 5 pt but did not decrease steadily in 4 pt, where 2 pt showed an increase at 1 to 2 weeks after SRT and 2 pt showed an increase at more than 3 months after SRT. The former appears to reflect the acute reaction to SRT and the latter radiation-induced pneumonitis. Although the addition of Met-PET did not provide additional information over FDG-PET, FDG- and Met-PET could be used to evaluate the treatment effect of SRT.

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Authors and Affiliations

  1. Department of Nuclear Medicine and Diagnostic Imaging, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shogoin, 606-8507, Sakyo-ku, Kyoto, JAPAN

    Takayoshi Ishimori, Tsuneo Saga, Yuji Nakamoto, Tatsuya Higashi, Marcelo Mamede, Takahiro Mukai & Junji Konishi

  2. Department of Therapeutic Radiology and Oncology, Graduate School of Medicine, Kyoto University, JAPAN

    Yasushi Nagata, Yoshiharu Negoro, Tetsuya Aoki & Masahiro Hiraoka

Authors
  1. Takayoshi Ishimori
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  2. Tsuneo Saga
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  3. Yasushi Nagata
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  4. Yuji Nakamoto
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  5. Tatsuya Higashi
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  6. Marcelo Mamede
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  7. Takahiro Mukai
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  8. Yoshiharu Negoro
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  9. Tetsuya Aoki
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  10. Masahiro Hiraoka
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  11. Junji Konishi
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Corresponding author

Correspondence to Tsuneo Saga.

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Ishimori, T., Saga, T., Nagata, Y. et al. 18F-FDG and11C-methionine PET for evaluation of treatment response of lung cancer after stereotactic radiotherapy. Ann Nucl Med 18, 669–674 (2004). https://doi.org/10.1007/BF02985960

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  • DOI: https://doi.org/10.1007/BF02985960

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